Articles tagged "Tolerance"

2020 American Transplant Congress
Immune Checkpoint PD-L1 Pathway as an Effective Platform for Localized Immunomodulation to Attain Indefinite Allogeneic Islet Graft Survival
L. Batra¹, P. Shrestha¹, H. Zhao¹, K. B. Woodward¹, M. Tan¹, O. G. Nuno¹, A. Togay¹, M. M. Coronel², A. J. Garcia², H. Shirwan¹, E. S. Yolcu¹
¹Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY, ²Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA
*Purpose: Allogenic islet transplantation is an effective therapeutic approach for the treatment of T1D. However, chronic immunosuppression to control rejection is a major limitation. The…
2020 American Transplant Congress
Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells
B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng
Pathology, University of Western Ontario-LHSC, London, ON, Canada
*Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
2020 American Transplant Congress
HLA Cross-Dressing of Dendritic Cells by Maternal Exosomes is Associated with PD-L1 Expression in Newborns
D. Lema¹, S. Kanaan², J. Nelson², W. Burlingham¹
¹University of Wisconsin-Madison, Madison, WI, ²Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Recipients of a kidney transplant from a haplo-identical sibling had accelerated early acute rejection episodes, followed by improved long-term graft survival if the transplant…
2020 American Transplant Congress
Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation
J. A. Sullivan, J. H. Fechner, E. Jankowska-Gan, W. J. Burlingham, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: The development and maintenance of peripheral tolerance is required for long term success of solid organ transplantation without immuno-suppressive drugs. Using a novel, post-transplant,…
2020 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Mathew¹, J. Galvin², L. Gallon¹, D. Belshe¹, K. Ravindra³, M. Horwitz³, J. Miller¹, S. Ildstad⁴
¹Northwestern, Chicago, IL, ²UIC, Chicago, IL, ³Duke, Durham, NC, ⁴U Louisville, Louisville, KY
*Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…
2020 American Transplant Congress
IL-6 Receptor Blockade But Not IL-2 Treatment Contributes to Long-Term NHP Cardiac Allograft Survival in Transient Mixed Chimeras
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, T. Costa¹, A. Dehnadi¹, I. M. Hanekamp¹, J. S. Allan³, G. Benichou¹, J. C. Madsen⁴
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Long-term tolerance of cardiac allografts has been achieved in non-human primates (NHPs) using a mixed chimerism protocol and by co-transplanting a kidney from the…
2020 American Transplant Congress
Intra-Lymph Node Injection of Rapamycin-Alloantigen Microparticles Regulates Dendritic Cell Antigen Presentation
C. M. Paluskievicz¹, Y. Xiong¹, W. Piao¹, M. Willson-Shirkey¹, H. Eppler², C. M. Jewell², J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²U Maryland, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) via intra-LN injections to shape both pro-inflammatory or…
2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
H. Liu, Y. Chen, F. Qiu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
2020 American Transplant Congress
Fate of Donor-Derived Regulatory Dendritic Cells (DCreg) and Augmentation of Host Regulatory T Cells Following Their Infusion Into Prospective Living-Donor Liver Transplant Recipients
A. W. Thomson, C. Macedo, A. F. Zahorchak, X. Gu, A. Humar, F. G. Lakkis, M. A. Styn, D. M. Metes
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Our purpose was to ascertain the fate of ex vivo-generated donor-derived DCreg and their influence on host T cells prior to transplant in a…
2020 American Transplant Congress
Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection
D. Ueda, H. Tsuda, S. Miyairi, R. L. Fairchild
Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…