Articles tagged "Tolerance"

2021 American Transplant Congress
Prediction of Renal Allograft Tolerance by Machine Learning
Q. Fu¹, K. Deng², H. Yang¹, S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: An ideal goal of transplantation is to withdraw or minimize immunosuppressants via the induction of tolerance to overcome drug toxicity, prolong allograft survival, and…
2021 American Transplant Congress
Expansion of Cd45ra-foxp3hi Activated Regulatory T Cells Predict Immune Tolerance in Patients with Combined Kidney and Bone Marrow Transplantation
Y. Kwon¹, K. Lee², J. Park²
¹Transplantation Research Center, Samsung Medical Center, Seoul, Korea, Republic of, ²Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Simultaneous transplantation of a solid organ and bone marrow from an identical donor is a possible means of achieving transplant tolerance. Here, we attempted…
2020 American Transplant Congress
High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction
R. Bellmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. Bläsing¹, F. Ius², W. Sommer², J. Kühne¹, L. Horn¹, A. Knöfel², I. Tudorache², A. Haverich², D. Jonigk³, G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, ³Institute of Pathology, Hannover Medical School MHH, Hannover, Germany
*Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…
2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
Y. Guo¹, F. Messner¹, B. Oh¹, G. Furtmüller¹, W. Lee¹, D. Cooney¹, L. Luznik², G. Brandacher¹
¹Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
2020 American Transplant Congress
Role of APC Subsets in Rejection and Graft-Versus-Host-Disease in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. S. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: Intestinal transplantation (ITx) is arguably the most immunogenic and complex organ transplantation, often accompanied with high rates of allograft rejection (AR) and graft-versus-host disease…
2020 American Transplant Congress
Plasma Cells Are Not Necessary for Regulatory B Cells and Preventing Their Differentiation Markedly Prolongs Allograft Survival
W. Yuan, Q. Ding, D. Rothstein
Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Plasma Cells (PCs) are the primary source of circulating antibodies. PCs were reported to be the major source of B-cell lineage IL-10, and absence…
2020 American Transplant Congress
The Requirement of Thymic Irradiation for Induction of Mixed Chimerism and Renal Allograft Tolerance in Non-Human Primates
T. Hirose¹, H. Sasaki¹, T. Oura¹, D. Ma¹, A. Dehnadi¹, R. B. Colvin², I. Rosales², A. B. Cosimi¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Thymic irradiation (TI) has been required for consistent induction of allograft tolerance through a mixed chimerism approach in both murine and nonhuman primate (NHP)…

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