ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2022 American Transplant Congress

    Experience with Covid-19 Infection and Vaccination in Combined Kidney/HSCT Recipients

    M. Gibson1, D. Belshe1, G. Gregory1, S. Tanna1, M. Ison1, S. Ildstad2, J. R. Leventhal1

    1Northwestern University, Chicago, IL, 2University of Louisville, Louisville, KY

    *Purpose: Kidney transplant(KTx) recipients are at increased risk of COVID-19 related complications. KTx pts who have undergone therapy to induce tolerance are a unique cohort…
  • 2022 American Transplant Congress

    Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey

    H. Sakai1, E. Berglund1, S. Chaudhry1, Y. Kato1, E. Duggan1, J. Weiner1, P. Alonso-Guallart1, N. Llore1, K. Brustle1, J. Stern1, B. Piegari1, D. Ekanayake-Alper1, M. Martinez2, G. Pierre1, M. Danton1, S. Kofman1, D. Ordanes1, D. Hajosi1, J. Lefkowitch3, A. Iuga1, T. Kato4, A. Griesemer1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Departments of Pathology and Cell Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…
  • 2022 American Transplant Congress

    Characterization of GZMB+ Bregs Transcriptome and Their Impact on Target Cells in Single-Cell RNA-seq

    N. Sailliet, H. Le Mai, A. Dupuy, F. Cynthia, M. Chesneau, J. Poschmann, R. Danger, S. Brouard

    CRTI- INSERM UMR 1064, Nantes, France

    *Purpose: During the inflammatory process, the immune system capacity to regulate itself is mandatory to balance effector positive feedback, avoid allergies and autoimmunity. Different subsets…
  • 2022 American Transplant Congress

    Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft

    E. S. Szuter1, T. Yokose1, M. T. Guinn1, J. Ge2, I. Rosales3, B. Kwon4, P. S. Russell1, A. Cuenca2, D. Kreisel5, P. Sage6, J. C. Madsen1, R. B. Colvin3, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Boston Children's Hospital, Boston, MA, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, 4Harvard College, Cambridge, MA, 5Department of Surgery, Washington University, St. Louis, MO, 6Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA

    *Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
  • 2022 American Transplant Congress

    Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes

    M. Nunez1, S. Wisel2, J. Gardner3, G. Worner4, G. Roll5, S. Syed3, G. Szot1, M. Tavakol1, K. Johnson1, A. Posselt4, P. Stock6

    1Surgery, University of California, San Francisco, San Francisco, CA, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3University of California, San Francisco, San Francisco, CA, 4University of California San Francisco, San Francisco, CA, 5UCSF Medical Center, San Francisco, CA, 6Univ of California-San Francisco, San Francisco, CA

    *Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…
  • 2022 American Transplant Congress

    Urinary Metabolomic Profiling from Spontaneous Tolerant Kidney Transplanted Recipients Shows Enrichment in Tryptophan-Derived Metabolites

    L. Colas1, A. Royer2, J. Massias3, M. Chesneau1, C. Kerleau4, P. Guérif4, M. Giral4, Y. Guitton2, S. Brouard1

    1CRT2I, Université de Nantes, Nantes, France, 2LABERCA, ONIRIS, Nantes, France, 3LABERCA, ONRIS, Nantes, France, 4Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France

    *Purpose: Operational tolerance is the holy grail in solid organ transplantation. Previous reports showed that the urinary compartment of operationally tolerant recipients harbored a specific…
  • 2022 American Transplant Congress

    Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance

    R. A. Sosa1, T. Mone2, B. V. Naini1, D. B. Kohn3, E. F. Reed1, K. Wheeler2, B. Campo-Fernandez3, A. Davila3, D. J. Chaffin4, J. DiNorcia5, F. M. Kaldas5, A. Cohen2, E. Lum6, J. L. Veale7, N. M. Kogut7

    1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2One Legacy, Los Angeles, CA, 3Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, 4LifeStream Blood Bank, San Bernadino, CA, 5Surgery, UCLA, Los Angeles, CA, 6Medicine, UCLA, Los Angeles, CA, 7Urology, UCLA, Los Angeles, CA

    *Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
  • 2022 American Transplant Congress

    Regulatory Gene Pathways Are Upregulated in Heart Transplant Biopsies with Quilty Lesions

    Q. Cai, L. De Las Casas, J. Torrealba

    Pathology, UTSW Medical Ctr, Dallas, TX

    *Purpose: Quilty lesions (QL) are commonly sub-endocardial lymphoid aggregates found in biopsies from heart transplants. Their appearance and presence in the cardiac tissue is still…
  • 2022 American Transplant Congress

    Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts

    T. Yokose1, E. S. Szuter1, M. T. Guinn1, J. Ge2, I. Rosales3, M. Ford4, P. S. Russell1, A. G. Cuenca2, J. C. Madsen1, R. B. Colvin1, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, 4Department of Surgery, Emory University, Atlanta, GA

    *Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…
  • 2022 American Transplant Congress

    Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival

    R. Steiner1, A. M. Weijler1, M. Muckenhuber2, J. Sprent3, T. Wekerle4, N. Pilat1

    1Medical University of Vienna, Vienna, Austria, 2Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, 3Garvan Institute of Medical Research, Sydney, Australia, 4Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria

    *Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
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