Articles tagged "Tolerance"

2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1^LowPD-1^HighCD8⁺ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
T. Ota¹, R. Goto¹, T. Harada¹, Y. Ganchiku¹, M. Zaitsu¹, A. Forgioni¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹
¹Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, ²Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
T. J. Borges¹, N. Murakami², I. T. Lape¹, R. B. Gassen¹, K. Liu¹, L. V. Riella¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…
2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
A. R. Gupta¹, J. Wang², C. Lareau³, I. Sun², J. Bautista¹, J. Gardner¹
¹Department of Surgery, University of California San Francisco, San Francisco, CA, ²Diabetes Center, University of California San Francisco, San Francisco, CA, ³Department of Pathology, Stanford University, Stanford, CA
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…
2022 American Transplant Congress
Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation
B. Schreiber, S. Tripathi, A. Sonawane, M. Blaser, S. Kuraoka, S. Singh, M. Aikawa, E. Aikawa, A. Chandraker
Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…
2022 American Transplant Congress
Novel Phenotype of Intragraft Endothelial Cells That Modulates CD4⁺ T Effector-Mediated Rejection
J. Wedel, K. Liu, T. Seto, S. Kong, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: Previous studies have suggested that early adoptive transfer of Teff into Rag KO mice bearing cardiac transplants results in acute rejection. However, if transfer…
2022 American Transplant Congress
Intrinsic DEPTOR Activity Modulates Treg Subset Differentiation
J. Wedel¹, M. Maslyar¹, B. Alsairafi¹, S. Kong², D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We have previously reported that DEPTOR activity within CD4+Foxp3+ Tregs increases immunomodulation following transplantation. DEPTOR functions by both stabilization of Foxp3 expression through epigenetic…
2022 American Transplant Congress
Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol
S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman
University of Wisconsin, Madison, WI
*Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
2022 American Transplant Congress
A Novel IL-2 Mutein Selectively Expands Regulatory T Cells and Prolongs Skin Graft Survival
O. Efe¹, T. J. Borges¹, R. B. Gassen¹, L. Morena¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Bobcock², J. C. Madsen¹, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Visterra, Inc., Waltham, MA
*Purpose: Promoting immune regulation through expansion of regulatory T cell (Treg) may allow immunosuppression minimization and improve long-term graft outcomes. Low-dose IL-2 is known to…
2022 American Transplant Congress
Phase I/ii Car-Treg Cell Therapy Clinical Trial To Induce Long-term Tolerance In Liver Transplant Patients
A. Sanchez-Fueyo¹, A. Taylor¹, D. Collin², C. Nathalie², S. Chris², M. Martinez-Llordella², N. Belmonte², I. McGill², D. Hartl²
¹King's College London, London, United Kingdom, ²Quell Therapeutics Ltd, London, United Kingdom
*Purpose: Life-long pharmacological immunosuppression (IS) is considered essential to prevent rejection following liver transplantation (LT), but is associated with significant side effects such as infections,…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…

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