ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T helper cells"

  • 2017 American Transplant Congress

    Loss of Bat3 Could Promote Transplant Tolerance by Regulating CD4 + T Cells Function.

    G. Gu, H. Hang, Q. Xia.

    Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Objective: To explore the effect of Bat3 on T cells and its function in transplant tolerance inductionMethodsWe generated Bat3flox/flox CD4-Cre + mice, sorted WT and…
  • 2017 American Transplant Congress

    CD8+ TAb-supp Cells Are Key Inhibitors of Humoral Alloimmunity by Inhibiting CD4+TFH Cells and Killing Germinal Center B Cells.

    J. Zimmerer, C. Avila, S. Elzein, B. Ringwald, R. Warren, G. Bumgardner.

    Surgery, The Ohio State University Wexner Medical Center, Columbus, OH

    Alloantibodies (alloAb) play a critical role in acute and chronic rejection after transplantation (Tx). It is well known that CD4+ T cells and B cells…
  • 2017 American Transplant Congress

    Pre-Transplant Circulating TNFR2+ Regulatory T Cells Predict Acute Rejection within the First 6 Months After Kidney Transplantation.

    M.-T. Nguyen,1 S. Sahakian,2 S. Liu,2 Y. Wang,2 J. Tchervenkov,2 S. Paraskevas.2

    1Department of Surgery, Columbia University, New York, NY; 2Department of Surgery, McGill University, Montreal, QC, Canada

    Background: Acute rejection (AR) mostly occurs during the first 6 months after kidney transplantation and contributes importantly to graft loss. Diagnosis relies on changes in…
  • 2017 American Transplant Congress

    TFR:TFH Cell Ratio Correlates with Anti-Donor Germinal Center Reactivity and Donor-Specific Antibody Formation Following Transplantation.

    G. La Muraglia II, M. Ford, I. Badell.

    Emory Transplant Center, Emory University School of Medicine, Atlanta, GA

    Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Although short-term outcomes are excellent, long-term allograft survival rates remain inadequate. It…
  • 2016 American Transplant Congress

    Single Cell Profiling of Th9 Cells Allows Identification of Functionally Different Subsets.

    K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki.

    Institute of Medical Immunology, Charite University Medicine, Berlin, Germany.

    T helper type 9 (Th9) cells represent a distinct subset of CD4+ effector T cells that is characterized by high secretion of interleukin (IL)-9. Protective…
  • 2016 American Transplant Congress

    The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.

    K. Hotta, T. Oura, B. Cosimi, T. Kawai.

    Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.

    Background:Regulatory T cell (Treg) immunotherapy has been applied to minimize the immunosuppressive drugs in clinical transplantation. To avoid contamination of CD4+CD25- T cells, only highly…
  • 2016 American Transplant Congress

    Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory TFH and TCONV CD4+ T Cells.

    C. Macedo, F. Paul, Y. Masaki, H. Kevin, M. Diana.

    Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA.

    Background: It is well accepted that human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. While our previous analysis showed…
  • 2016 American Transplant Congress

    Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.

    J. Xu, Y. Zhang, L. Wang, X. Li, R. Chen, R. Zhang, Y. Ding.

    Department of Immunology, Capital Medical University, Beijing, China.

    Background: Development of obliterative bronchiolitis (OB) is the biggest obstacle that limits long-term allograft survival and clinical application of lung transplantation, and the precise mechanisms…
  • 2016 American Transplant Congress

    Limiting Helper Functions of CD4 T Cells Improves Efficacy of Induction Therapy without Compromising Responses to Third Party Antigens.

    K. Ayasoufi, V. Gorbacheva, F. Ran, A. Valujskikh.

    Cleveland Clinic, Cleveland.

    Antibody mediated lymphocyte depletion is commonly used in clinical transplantation. However, memory T cells undermine the efficacy of lymphoablative induction therapies in sensitized transplant recipients.…
  • 2016 American Transplant Congress

    Nuclear Factor of Activated T-Cells Post-Renal Transplant.

    K. Tornatore,1,4 K. Attwood,2 O. McGuire,3 K. O'Loughlin,3 R. Venuto,4 H. Minderman.3

    1Translational Pharmacology Research Center, School of Pharmacy, Buffalo; 2Biostatistics, School of Public Health, Buffalo; 3Flow Cytometry Laboratory, Roswell Park Cancer Institute, Buffalo; 4Medicine, School of Medicine, University at Buffalo, Buffalo.

    Background: Nuclear Factor of Activated T-cells (NFAT1) is a transcription factor regulating the expression of key targets involved with cellular immune function. Calcineurin is a…
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