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American Transplant Congress abstracts

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Articles tagged "T helper cells"

  • 2022 American Transplant Congress

    Batf3 and IRF4 in Control of iTreg Differentiation, Stability, and Survival

    P. Arnold, X. Xiao, X. Zhang, M. Wen, G. Wang, X. Chu, X. C. Li

    Houston Methodist Research Institute, Houston, TX

    *Purpose: The use of in vitro-differentiated induced Tregs (iTregs) in transplantation and various diseases is a promising therapeutic that is limited by challenges to iTreg…
  • 2022 American Transplant Congress

    TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3+ Treg

    C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford

    Emory University Transplant Center, Emory University, Atlanta, GA

    *Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
  • 2022 American Transplant Congress

    Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

    J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
  • 2022 American Transplant Congress

    T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism

    T. J. Borges1, N. Murakami2, I. T. Lape1, R. B. Gassen1, K. Liu1, L. V. Riella1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…
  • 2021 American Transplant Congress

    CD40 Blockade by the Fc-Silent Immunosuppressive Antibody Iscalimab Results in Diminished B Cell Activation and Differentiation and is Paralleled by Whole Blood Gene Expression Data

    R. Kraaijeveld1, M. W. van den Hoogen1, A. E. de Weerd1, E. Ferroro2, G. Robert2, U. Laessing2, B. Haraldsson2, J. S. Rush2, C. C. Baan1

    1Erasmus MC, Rotterdam, Netherlands, 2Novartis Pharmaceuticals AG, Basel, Switzerland

    *Purpose: Blockade of costimulatory molecule CD40 by the Fc-silent immunosuppressive drug Iscalimab has shown to inhibit acute alloreactivity in non-human primates and is currently being…
  • 2021 American Transplant Congress

    Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways

    R. Dhital1, V. Velazquez1, Q. Zeng2, B. Graber1, K. Flint1, M. Shimamura1

    1Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, 2Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH

    *Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…
  • 2021 American Transplant Congress

    Invariant Nkt Cells Promote Expansion of Novel Cxcr3+Ccr4+Cd8+ T Cells in the Liver Following Allogeneic Hepatocyte Transplant

    J. Zimmerer1, B. Ringwald2, S. Chaudhari1, J. Han1, C. M. Peterson1, R. T. Warren1, M. Hart1, M. Abdel-Rasoul3, G. Bumgardner1

    1OSU, Columbus, OH, 2Medical Student Research Program, OSU, Columbus, OH, 3Center for Biostatistics, OSU, Columbus, OH

    *Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…
  • 2021 American Transplant Congress

    Targeting Il-21 Receptor Shifts Tfh/tfr Balance and Ameliorateschronic Antibody Mediated Rejection

    Y. Nian, Z. Xiong, J. Zhao, Y. Fu

    Tianjin First Central Hospital, Tianjin, China

    *Purpose: Donor specific antibody (DSA) plays a central role in chronic kidney allograft injury. As a trigger of humoral alloimmune response, follicular T helper cells(Tfh)…
  • 2021 American Transplant Congress

    Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation

    S. Zeng, E. S. Crichton, I. R. Badell

    Department of Surgery, Emory, Atlanta, GA

    *Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
  • 2020 American Transplant Congress

    Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter

    S. K. Eskandari1, J. B. Alhaddad1, I. Sulkaj2, M. B. Melo2, N. Li2, H. Allos1, B. Kollar1, M. A. Seelen3, D. J. Irvine4, J. Azzi1

    1Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA, 3Nephrology, University Medical Center Groningen, Groningen, Netherlands, 4Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA

    *Purpose:
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