2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…2021 American Transplant Congress
Establishing a Linear Program for the Development of Costimulation Resistant T-Cells
*Purpose: CD4+CD57+PD1-T-cells are primed effectors capable of mediating belatacept-resistant rejection, however, the developmental program giving rise to these cells has not been elucidated in detail.…2021 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure
1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA
*Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…2021 American Transplant Congress
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…2021 American Transplant Congress
Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury
*Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…2021 American Transplant Congress
Distinct Phenotype and Function of Antibody-suppressor Cxcr5+Cd8+ T Cells
*Purpose: We have reported that the novel subset of antibody-suppressor CD8+ T cells (termed CD8+ TAb-supp cells) require the expression of CXCR5. In addition, alloprimed…2021 American Transplant Congress
Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts
*Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…
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