Articles tagged "T cells"

2022 American Transplant Congress
Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection
J. Hjortdal¹, M. Griffin², C. C. Murphy³, S. Brouard⁴, N. Degauque⁴
¹Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark, ²National University of Ireland, Galway, Galway, Ireland, ³Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁴Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
*Purpose: Acute rejection (AR) of allogeneic corneal transplantation (CT) has a profound effect on subsequent graft survival, indicating that immunological damage is often not fully…
2022 American Transplant Congress
Zfyve21 Activates T Cell Intrinsic, Nlrp3 Inflammasomes to Promote Allograft Vasculopathy
D. Antoine¹, B. Jiang¹, Q. Jiang¹, X. Li¹, S. Guiyu¹, M. Fan¹, G. Tellides², A. Geirsson³, D. Jane-wit³
¹Dept of Cardiovascular Medicine, Yale University, New Haven, CT, ²Dept of Cardiothoracic Surgery, Yale University, New Haven, CT, ³Yale University, New Haven, CT
*Purpose: Allograft vasculopathy (AV) is a complication of chronic allograft rejection whose underlying mechanism(s) of etiopathogenesis are poorly defined. We examined the role of ZFYVE21,…
2022 American Transplant Congress
Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients
K. Deng¹, N. Tanimine², C. Breeden³, B. Burrell³, G. Gaile³, K. Lee¹, R. Matheson¹, F. Qiang¹, C. Rickert¹, C. LeGuern¹, J. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, ³Immune Tolerance Network, Bethesda, MD
*Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
2022 American Transplant Congress
Deficiency of Antibody-Suppressor CXCR5⁺CD8⁺ TCells (Not CD4⁺ T_regs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients
J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹
¹Dept of Surgery, The Ohio State University, Columbus, OH, ²Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH
*Purpose: Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to high alloantibody (alloAb) production, rapid allograft rejection,…
2022 American Transplant Congress
Local Cognate Antigen in Kidney Allografts Promotes Tissue Resident Memory T Cell Maintenance
R. Tieu¹, Q. Zeng¹, D. Zhao¹, P. Manandhar², A. Williams¹, K. Abou-Daya¹, L. Kane², W. Shlomchik¹, M. Oberbarnscheidt¹, F. Lakkis¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Our lab has demonstrated that tissue resident memory T cells (TRM cells) sustain chronic kidney allograft rejection in mice. It remains unknown how TRM…
2022 American Transplant Congress
The Promise Of Tolerance In Living Donor Kidney Transplant (LDKT): A Retrospective, Real-world Assessment Of The Safety And Efficacy Of LDKT With FCR001 Investigational Cell-therapy Compared With Standard Of Care (SOC)
N. Krieger¹, J. R. Leventhal², B. Ho³, M. Richards⁴, D. Schaumberg⁴, S. Ildstad⁵, D. Axelrod⁶
¹Talaris Therapeutics, Inc, Wellesley, MA, ²SURGERY, Northwestern Medicine, Chicago, IL, ³Comprehensive Transplant Ctr, Chicago, IL, ⁴Evidera, Bethesda, MD, ⁵Talaris Therapeutics, Inc., Louisville, KY, ⁶University of Iowa, Iowa City, IA
*Purpose: FCR001 (FCR) is a cell therapy derived from mobilized donor PBMCs including hematopoietic progenitor cells, facilitating cells, and αβ T cells, intended to establish…
2021 American Transplant Congress
A Mechanistic Evaluation to Guide the Optimal Immunosuppression Adjustment Strategy in Transplant Patients with COVID-19
V. Hall, V. Ferreira, D. Kumar, A. Humar
UHN, Toronto, ON, Canada
*Purpose: The optimal management of immunosuppression in transplant patients infected with COVID-19 is unknown. Reduction in calcineurin inhibitors or antimetabolite doses is often performed in…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
Nomogram of Quantity of Peripheral Cxcr5⁺Cd8⁺ T Cells, Aims to Predict Risk of De Novo Dsa in First-time Kidney Transplant Recipients
J. Zimmerer¹, M. Abdel-Rasoul², G. Bumgardner¹
¹OSU, Columbus, OH, ²Center for Biostatistics, OSU, Columbus, OH
*Purpose: We recently reported that peripheral CXCR5+CD8+ T cells are inversely associated with the risk of developing de novo DSA (dnDSA) in the first year…
2021 American Transplant Congress
Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups
H. C. Copley¹, L. Gragert², A. R. Leach³, V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Pathology, Tulane University School of Medicine, New Orleans, LA, ³European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
*Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…

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