ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cells"

  • 2022 American Transplant Congress

    Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation

    B. Schreiber, S. Tripathi, A. Sonawane, M. Blaser, S. Kuraoka, S. Singh, M. Aikawa, E. Aikawa, A. Chandraker

    Brigham and Women's Hospital, Boston, MA

    *Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…
  • 2022 American Transplant Congress

    Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health

    M. Rao1, M. Amouzgar1, J. T. Harden1, M. Lapasaran1, A. Trickey1, B. Armstrong2, J. Odim3, T. Debnam3, C. Esquivel1, S. C. Bendall1, O. Martinez1, S. M. Krams1

    1Stanford University, Palo Alto, CA, 2Rho, Durham, NC, 3National Institutes of Health, Bethesda, MD

    *Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…
  • 2022 American Transplant Congress

    Impact of Immunosuppression on T-cell Responses After mRNA-Based Sars-CoV-2 Vaccination

    E. Wong1, N. L. Bert2, H. K. Sran1, A. Lim1, M. D'Costa1, K. Akalya2, S. Hang2, A. Bertoletti2, A. Vathsala1

    1National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore, 2Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore

    *Purpose: Administration of mRNA-based SARS-CoV-2 vaccines confers protection from SARS-CoV-2 infection and reduces its severity in the general population. It has been suggested that mounting…
  • 2022 American Transplant Congress

    Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance

    L. Wang1, G. J. Babcock2, W. W. Hancock3

    1Pathology and Lab Medicine, Childrens Hospital of Philadelphia, Philadelphia, PA, 2Visterra, Inc., Waltham, MA, 3Pathology and Lab Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: New therapeutic approaches to the management of transplant recipients are warranted in efforts to improve outcomes.*Methods: We have engineered a modified human IL-2 protein…
  • 2022 American Transplant Congress

    Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles

    J. S. Rink1, Y. Sambandam2, J. He2, J. Mathew3, J. R. Leventhal4, C. S. Thaxton5

    1Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, 2Comprehensive Transplant Center, Northwestern University, Chicago, IL, 3Northwestern University, Chicago, IL, 4Surgery, Northwestern Medicine, Chicago, IL, 5Department of Urology, Northwestern University, Chicago, IL

    *Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
  • 2022 American Transplant Congress

    Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells

    E. Landmann1, P. Ruiz1, A. Kurt1, E. Kodela1, M. Martinez-Llordella2, A. Sanchez-Fueyo1

    1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom

    *Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
  • 2021 American Transplant Congress

    Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury

    H. Jin, M. Li, C. Zhang, G. Sun, D. Zhang

    Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…
  • 2021 American Transplant Congress

    Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation

    S. Zeng, E. S. Crichton, I. R. Badell

    Department of Surgery, Emory, Atlanta, GA

    *Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
  • 2021 American Transplant Congress

    The Gut Microbiotainduces Local and Systemic Immune Modulation

    V. Saxena, R. Lakhan, J. Iyyathurai, W. Piao, L. Li, T. Zhang, M. W. Shirkey, B. Ma, E. F. Mongodin, J. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…
  • 2021 American Transplant Congress

    Distinct Phenotype and Function of Antibody-suppressor Cxcr5+Cd8+ T Cells

    J. Zimmerer, J. Han, M. Hart, S. Chaudhari, C. Peterson, G. Bumgardner

    OSU, Columbus, OH

    *Purpose: We have reported that the novel subset of antibody-suppressor CD8+ T cells (termed CD8+ TAb-supp cells) require the expression of CXCR5. In addition, alloprimed…
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