Articles tagged "T cells"

2015 American Transplant Congress
Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients
M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 S. Brouard,^1,2 N. Degauque.^1,2
¹UMR 1064, INSERM, Nantes, France; ²ITUN, CHU de Nantes, Nantes, France; ³Faculté de Médecine, Université de Nantes, Nantes, France.
Objective. Historical classification to distinguish central memory (CM), naïve, effector memory (EM), and terminally-differentiated effector memory (TEMRA) CD8 T cells is based on CD45RA and…
2015 American Transplant Congress
Ex Vivo Expansion With Rapamycin Enhances the Suppressive Function of Regulatory T Cells (Tregs) Isolated from Pediatric Thymus
E. Dijke,^1,2,3 R. Hoeppli,^3,4 T. Ellis,^1,2 J. Pearcey,^1,2 I. Larsen,^1,2 I. Rebeyka,^1,2 D. Ross,^1,2 M. Levings,^3,4 L. West.^1,2,3
¹University of Alberta, Edmonton, AB, Canada; ²Alberta Transplant Institute, Edmonton, AB, Canada; ³Canadian National Transplant Research Program, Edmonton/Vancouver, AB/BC, Canada; ⁴University of British Columbia, Vancouver, BC, Canada.
INTRODUCTION: Treg-based cellular therapy to suppress graft-directed immunity could reduce the need for life-long immunosuppressive drugs. Challenges include isolation and expansion of pure Tregs to…
2015 American Transplant Congress
Recipient IL-33 Promotes Type 1 Alloimmunity and Lethal Acute GVHD Following alloHCT
B. Matta,¹ D. Reichenbach,² V. Schwarze,³ V. Tkachev,⁴ L. Mathews,¹ Q. Liu,¹ M. Warncke,⁵ J. Ferrara,⁴ R. Zeiser,³ B. Blazar,² H. Turnquist.¹
¹Surgery, Univ. of Pittsburgh, Pittsburgh, PA; ²Pediatrics, Univ. of Minnesota, Minneapolis, MN; ³Hematology and Oncology, Univ. Medical Center Freiburg, Freiburg, Germany; ⁴Pediatrics, Univ. of Michigan, Ann Arbor, MI; ⁵Novartis Institute for Biomedical Research, Basel, Switzerland.
Background: Graft-versus-host disease (GVHD) is a common complication of allogeneic (allo) hematopoietic cell transplantation (HCT) that limits its widespread application for the induction of transplant…
2015 American Transplant Congress
Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients
M. Ezzelarab,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ W. Shufesky,¹ D. Cooper,¹ A. Morelli,^1,2 A. Thomson.^1,2
¹Surgery - Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:Memory T cells (Tmem), particularly those resistant to costimulation blockade (CoSB), are considered a major barrier to transplant tolerance. The T-box transcription factor Eomesodermin (Eomes)…
2015 American Transplant Congress
Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P
C. Brinkman, Y. Xiong, J. Bromberg.
University of Maryland, Baltimore, MD.
Introduction: Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates cell egress from lymphoid and non-lymphoid tissues. While S1P has been described as a chemoattractant, its…