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Articles tagged "T cells"

  • 2015 American Transplant Congress

    Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation

    E. Lee, H. Kim, G. Demirci.

    Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.

    Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…
  • 2015 American Transplant Congress

    Increased Frequency of Terminally Differentiated and Exhausted CD8+ T Cells Is Associated With Adverse Clinical Outcome After Mechanical Circulatory Support Device Implantation

    J. Schaenman,1 Y. Korin,2 T. Sidwell,2 G. Sunga,2 G. Bondar,3 N. Wisniewski,3 M. Kwon,4 M. Cadeiras,3 M. Deng,3 E. Reed.2

    1Medicine/Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; 3Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 4Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Clinical outcomes vary after mechanical circulatory support device (MCSD) implantation, with some patients developing multi organ system dysfunction (MOD), sometimes leading to death. We hypothesized…
  • 2015 American Transplant Congress

    Donor Specific Expansion of Regulatory T-Cells Was Associated With Allograft Tolerance Induced By Transient Mixed Chimerism in Nonhuman Primates

    K. Hotta, A. Aoyama, T. Ohura, M. Tonsho, Y. Yamada, J. Allan, J. Madsen, B. Cosimi, G. Benichou, T. Kawai.

    Transplant Center, Massachusetts General Hospital, Boston, MA.

    Background: We have previously reported successful induction of solid organ allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Since these recipients achieved…
  • 2015 American Transplant Congress

    Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function

    K. Sivanathan,1,2,3 D. Rojas-Canales,1,2 S. Grey,5 C. Hope,1,2 R. Carroll,1,4 S. Gronthos,3,6 P. Coates.1,2,3,4

    1Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 2School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; 3Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia; 4Central Northern Adelaide Renal Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 5Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; 6Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.

    Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…
  • 2015 American Transplant Congress

    The Immunosuppressive Effect of CTLA4Ig Monotherapy Depends On the Presence of Tregs Only at Suboptimally Low Doses

    C. Schwarz,1 L. Unger,1 B. Mahr,1 K. Aumayr,2 N. Pilat,1 K. Hock,1 A. Farkas,1 I. Kristo,1 T. Wekerle.1

    1Dept. of Surgery, Medical University of Vienna, Vienna, Austria; 2Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

    Background: CTLA4Ig/belatacept has been recently approved for immunosuppression after renal transplantation. Concerns persist, however, that a paradoxical dose-response relationship might exist for CTLA4Ig in which…
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