Articles tagged "T cells"

2015 American Transplant Congress
Pre-Transplant Levels of TFH cell-Inducing Pro-Inflammatory Cytokines Correlate With DSA Formation After Kidney Transplantation
C. Macedo,¹ K. Hadi,¹ B. Elinoff,¹ M. Marrari,¹ A. Zeevi,¹ B. Ramaswami,¹ G. Chalasani,¹ A. Shields,² R. Alloway,³ E. Woodle,² F. Lakkis,¹ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Surgery, University of Cincinnati College of Medicine, Cincinnati; ³Internal Medicine-Nephrology, University of Cincinnati College of Medicine, Cincinnati.
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…
2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.
Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
S. Verma, Y. Tanaka, S. Shimizu, L. Das, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…
2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
F. Krenzien,¹ M. Quante,¹ A. ElKhal,¹ H. Uehara,¹ R. Abdi,² B. Slegtenhorst,¹ H. Biefer,¹ S. Tullius.¹
¹Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
2015 American Transplant Congress
Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin
J. Sullivan,¹ D. Wilkes,² T. Mohanakumar,³ W. Burlingham.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, Indiana University, Indianapolis, IN; ³Surgery, Washington University, St. Louis, MO.
Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
2015 American Transplant Congress
Identification of CXCR5⁺EBV-Specific CD8⁺ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
C. Macedo,¹ K. Hadi,¹ D. Rowe,² J. Luce,³ S. Webber,⁴ B. Feingold,³ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh; ³Pediatrics-Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh; ⁴Pediatrics, Vanderbilt University School of Medicine, Nashville.
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…
2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…
2015 American Transplant Congress
Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications
K. Gołąb,¹ O. Savari,¹ S. Ramachandran,¹ Z. Tekin,¹ M. Tibudan,¹ J. Millis,¹ P. Trzonkowski,² P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Immunology, Medical University of Gdansk, Gdansk, Poland.
Feasibility of clinical application of regulatory T cells (Tregs) in clinical transplantation would be improved if Tregs or pre-enriched cells for Treg isolation could be…
2015 American Transplant Congress
Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch
M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 D.-A. Laplaud,^1,2 S. Brouard,^1,2 C. Pecqueur,⁴ N. Degauque.^1,2
¹INSERM UMR1064, Nantes, France; ²CHU de Nantes, Nantes, France; ³University of Nantes, Nantes, France; ⁴INSERM UMR892, Nantes, France.
Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…
2015 American Transplant Congress
Boosting the Adaptive Immune Response Prevents the High Incidence of Herpes Zoster After Lung or Heart Transplantation
N. van Besouw,¹ S. Roest,² J. Zuijderwijk,¹ R. de Kuiper,¹ J. van Weezel,³ A. van der Eijk,⁴ W. Weimar,¹ P. Hal,³ O. Manintveld.²
¹Internal Medicine - Transplantation, Erasmus MC, Rotterdam, Netherlands; ²Cardiology, Erasmus MC, Rotterdam, Netherlands; ³Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; ⁴Viroscience, Erasmus MC, Rotterdam, Netherlands.
Purpose Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in ganglia from which it may reactivate leading to herpes zoster (HZ).…