Articles tagged "T cells"

2015 American Transplant Congress
Tracking T Cell Fate After Antithymocyte Globulin (ATG) Immunotherapy in Infant Heart Transplant (HTx) Patients
S.-I. Wang,^1,2 I. Larsen,^1,2 S. Urschel,^1,2 R. Chinnock,³ J. Rusch,³ L. West.^1,2
¹Univ. of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Loma Linda Univ., Loma Linda.
Polyclonal T cell depletion with ATG is a common induction therapy in adult and pediatric transplantation. In adults, T cell recovery post-ATG involves homeostatic proliferation…
2015 American Transplant Congress
Th17-Mediated Alloimmune Responses Play a Key Role in Intestinal Allograft Rejection in Humans
A. Kroemer, S. Wanta, J. Diaz, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein.
The Georgetown Transplant Institute, Washington, DC.
The majority of transplanted intestines still falls victim to allograft enteropathy, the underlying mechanisms of which are poorly understood. The purpose of this study was…
2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
B. Wiegmann,¹ C. Falk,² M. Seyda,² C. Neudörfl,² A. Akhdar,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke.¹
¹Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…
2015 American Transplant Congress
Diabetes Mellitus Predicts Outcome in Obesity After Kidney Transplantation
T. Schachtner,^1,2 P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
Obesity has been associated with an increased risk of graft loss and death after kidney transplantation. The role of cellular immunity in obese kidney transplant…
2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
J. Wedel, S. Bruneau, K. Liu, N. Kochupurakkal, M. Laplante, D. Briscoe.
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…
2015 American Transplant Congress
Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)
K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.
Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
2015 American Transplant Congress
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation
O. Bestard,^1,2 E. Crespo,¹ T. Sigdel,² S. Roedder,² Y. Ng,² J. Cruzado,¹ M. Lúcia,¹ S.-C. Hsieh,¹ T. Tran,¹ J. Grinyó,¹ M. Sarwal.¹
¹Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, CAT, Spain; ²Department of Transplant Surgery, UCSF, San Francisco, CA.
Subclinical allograft rejection (sc-AR) is still a main cause of allograft loss that can only be assessed through invasive surveillance biopsies. We sought to investigate…
2015 American Transplant Congress
miR-155 Different Roles in UCB iTreg and nTreg
Y. Lu, L. Lu.
Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…
2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
M. Miller, M. Daniels, Y. Wang, D. Yin, A. Chong, M.-L. Alegre.
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
2015 American Transplant Congress
PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization
E. Kefalogianni,¹ M. Mounayar,² B. Smith,² J. Azzi,² L. Chabtini,² P. Fiorina,² M. Kraus,³ R. Briddell,⁴ W. Fodor,⁵ A. Herrlich,¹ R. Abdi.²
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Brigham and Women's and Children's Hospital, Harvard Medical School, Boston, MA; ³Viacord LLC, a PerkinElmer Company, Cambridge, MA; ⁴ViaCord Processing Lab, Viacord LLC, a PerkinElmer Company, Hebron, KY; ⁵The Cell Therapy Group, Madison, CT.
The immunomodulatory capacity of mesenchymal stem cells (MSC) is critical for their use in therapeutic applications. MSC response to specific inflammatory cues allows them to…