2016 American Transplant Congress
Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.
1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.
S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…2016 American Transplant Congress
ASC-Deficient Dendritic Cells Exhibit Activation Defects and a Reduced Ability to Stimulate Allogeneic T Cells.
Medicine, University of California-San Diego, La Jolla, CA.
Donor dendritic cell (DC) activation causes adaptive immune responses that lead to rejection of transplanted allografts. Accumulating data suggest that inflammasome assembly within interstitial DCs…2016 American Transplant Congress
Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.
1Duke University, Durham; 2Emory University, Atlanta.
Purpose: Infection induces costimulation-resistant memory T cells with heterologous alloreactivity. Rapamycin has been shown to mitigate the effect of these cells in transplant rejection. Previous…2016 American Transplant Congress
Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.
Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…2016 American Transplant Congress
Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.
Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…2016 American Transplant Congress
Thymus Is Required for T Cells Reconstitution Following Antibody-Mediated Lymphoablation.
Antibody-mediated lymphocyte depletion is used as induction therapy in sensitized transplant recipients. Following lymphoablation, peripheral lymphopenia triggers homeostatic T cell proliferation (HP) and enhanced thymopoiesis.…2015 American Transplant Congress
CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant
Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…2015 American Transplant Congress
Erythropoietin (EPO) Has Treg Sparing Immunosuppressive Effects On Human Alloreactive T Cells
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Extending previous work showing that EPO inhibits alloreactive effector T cell proliferation by uncoupling IL2 receptor signaling (JASN 2014), we tested the effects of EPO…2015 American Transplant Congress
BK Virus-Specific Polyfunctional CD8+ T Cells Predicts Successful Control of BK Viremia After Kidney Transplantation
Introduction: BK Virus associated nephropathy (BKN) remains an important cause of graft loss after kidney transplantation. We hypothesized that analysis of the anti-BK virus immune…2015 American Transplant Congress
Aldosterone Acts Directly On T Cells, and Promotes Production of Inflammatory Cytokines
Department of Developmental, Molecular and Chemical Biolgy, Tufts University Medical School, Boston.
Aldosterone is a mineralocorticoid hormone involved in the regulation of blood electrolyte concentration, blood pressure and blood volume. The primary receptor for aldosterone is the…
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