Articles tagged "T cells"

2016 American Transplant Congress
Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.
R. Ishii,¹ T. Hirai,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…
2016 American Transplant Congress
Kidney Allotransplantation Induces the Differentiation of Antigen-Experienced CD8 T Cells with Enhanced Metabolic Profiles.
G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 S. Brouard,^1,3 C. Pecqueur,⁴ N. Degauque.^1,3
¹UMR 1064, INSERM, Nantes, France; ²Université de Nantes, Nantes, France; ³ITUN, CHU de Nantes, Nantes, France; ⁴UMR 892, INSERM, Nantes, France.
Background. Naïve and memory CD8 T cells have been shown to exhibit different metabolic profiles, especially upon antigen stimulation. However, it is unknown whether the…
2016 American Transplant Congress
Quantiferon-CMV Test, CMV-Specific ELISPOT and CMV-Dextramer Assays in Assessing the Risk of CMV Infection in Seropositive Kidney Transplant Recipients.
H. Lee,¹ K. Park,² J. Ryu,² J. Yu,³ B. Chung,³ C. Yang,³ E.-J. Oh.¹
¹Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea; ²Department of Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Korea; ³Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Human cytomegalovirus (CMV) infection is one of the primary opportunistic pathogens and is a leading cause of morbidity and mortality in kidney transplant recipients. Assessing…
2016 American Transplant Congress
Banked EBV-Specific T-Cells for Treatment of Rituximab Refractory EBV+ B-Cell Lymphoma in Solid Organ Transplantation Recipients.
S. Prockop,¹ E. Doubrovina,¹ C. Sauter,² S. Suser,¹ R. O'Reilly.¹
¹MKSCC, New York, NY; ²MSKCC, New York, NY.
Morbidity and mortality from EBV-induced post-transplant lymphoproliferative disease (EBV+ PTLD) can complicate solid organ transplant (SOT), particularly in those seronegative prior to transplant and in…
2016 American Transplant Congress
Foxp3 Controls Oxidative Phosphorylation in Regulatory T Cells.
U. Beier,¹ A. Angelin,² J. Jiao,¹ H. Xiao,¹ L. Wang,³ S. Dahiya,³ A. Wells,³ D. Wallace,² W. Hancock.³
¹Pediatric Nephrology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
Current immunosuppressive therapies are limited by non-specificity and toxicities, and new pharmacologic approaches to immunosuppressive therapies are needed. Many T cell subsets have distinct metabolic…
2016 American Transplant Congress
Administration of IL-33 Before Allogeneic Stem Cell Transplantation Expands Recipient Treg That Prevent Graft- vs. Host Disease.
B. Matta,¹ D. Reichenbach,² X. Zhang,¹ B. Koehn,² L. Mathews,¹ C. Feser,² M. Smith,² Q. Liu,¹ R. Zeiser,³ B. Blazar,² H. Turnquist.¹
¹Dept of Surgery and Starzl Transplant Inst, Univ of Pittsburgh Sch of Med, Pittsburgh, PA; ²Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; ³Univ Med Cntr Freiburg, Freiburgh, Germany.
Background: During allogeneic hematopoietic cell transplantation (alloHCT), non-hematopoietic cell IL-33 is augmented and released by recipient conditioning to promote Type 1 alloimmunity and lethal acute…
2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
S. Verma, Y. Tanaka, S. Shimizu, L. Das, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…
2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
F. Krenzien,¹ M. Quante,¹ A. ElKhal,¹ H. Uehara,¹ R. Abdi,² B. Slegtenhorst,¹ H. Biefer,¹ S. Tullius.¹
¹Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
2015 American Transplant Congress
Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin
J. Sullivan,¹ D. Wilkes,² T. Mohanakumar,³ W. Burlingham.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, Indiana University, Indianapolis, IN; ³Surgery, Washington University, St. Louis, MO.
Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
2015 American Transplant Congress
Identification of CXCR5⁺EBV-Specific CD8⁺ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
C. Macedo,¹ K. Hadi,¹ D. Rowe,² J. Luce,³ S. Webber,⁴ B. Feingold,³ D. Metes.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh; ³Pediatrics-Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh; ⁴Pediatrics, Vanderbilt University School of Medicine, Nashville.
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…