Articles tagged "T cells"

2016 American Transplant Congress
Polyclonal Treg Adoptive Therapy for Control of Subclinical Kidney Transplant Inflammation (TASK Pilot Trial).
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco, CA.
Purpose: Early renal graft inflammation is associated with progressive fibrosis & late dysfunction. Treg therapy can reverse established inflammation in animal models. We conducted a…
2016 American Transplant Congress
The Impact of Allograft Rejection on DNA Methylation After Kidney Transplantation.
K. Boer, E. de Wit, D. Hesselink, L. Hofland, M. Betjes, C. Baan.
ErasmusMC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Introduction DNA methylation is a well-known epigenetic mechanism which plays a critical role in cell function by regulating gene expression. Variations in DNA methylation are…
2016 American Transplant Congress
IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Gronthos,⁴ S. Grey,⁵ P. Coates.^1,2,3
¹School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ²Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research and Robinson Institute, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁴Mesenchymal Stem Cell Laboratory, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁵Transplant Immunology Group, Garvin Institute of Medical Research, Sydney, New South Wales, Australia.
Human bone marrow derived MSC-17 are superior T cell immunomodulators for allotransplantation. Untreated-MSC (UT-MSC) or 5 days IFNγ (MSCγ) or IL-17A (MSC-17) treated MSC were…
2016 American Transplant Congress
Initial Experience with Donor Specific Tregs in Kidney Transplantation.
J. Markmann,¹ E. Guinan,² E. Geissler,³ G. Cole,² S. Germana,¹ J. Kim,¹ B. Sawitzki.⁴
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Hematology/Oncology, Dana-Farber Cancer Center, Boston, MA; ³Surgery, Universitätsklinikum Regensburg, Regensburg, Germany; ⁴Institute of Medical Immunology, Charite Universitätsmedizin, Berlin, Germany.
Systematic multicenter clinical evaluation of regulatory cells is being conducted by the EU supported ONE Study trial in which each site is administering a different…
2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
A. Zahorchak,¹ L. Butterfield,^2,3 C. Macedo,¹ D. Hamm,⁴ D. Metes,^1,3 A. Thomson.^1,3
¹Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Medicine, University of Pittsburgh, Pittsburgh; ³Immunology, University of Pittsburgh, Pittsgurgh; ⁴Adaptive Biotech, Seattle.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…
2016 American Transplant Congress
HLA Identical Renal Transplant Tolerance Using Donor Hematopoietic Stems Cells (DHSC): Role of Immunoregulation.
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ X. Huang,¹ A. Tambur,¹ Y. Kanwar,¹ J. Charette,¹ M. Abecassis,¹ J. Miller.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²The Scripps Research Institute, La Jolla, CA.
Purpose: Despite being a “perfect match”, HLA-identical kidney transplants (HLA-Id KTx) are rejected without sufficient immunosuppression (IS), and hence can also benefit from tolerance induction.…
2015 American Transplant Congress
ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention
H. Xu,¹ T. Miller,¹ Y. Huang,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
2015 American Transplant Congress
Induction of iNOS Expressed Macrophages from Mouse iPS cells That Contribute to Prolong Same iPS Cells-Derived Graft Survival in Allogeneic Recipients
H. Sasaki,¹ H. Wada,² K. Morita,¹ K.-I. Seino,² N. Shinohara.¹
¹Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
BACKGROUND: Induced pluripotent stem cells (iPSCs)-technology provides new opportunities in regenerative medicine to generate grafts from donors for transplantation. However, particularly when allogeneic iPSCs are…
2015 American Transplant Congress
T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice
S. Noel,¹ M. Martina,² S. Bandapalle,¹ S. Reddy,³ L. Racusen,² A. Hamad,² H. Rabb.¹
¹Department of Medicine, Johns Hopkins University, Baltimore, MD; ²Department of Pathology, Johns Hopkins University, Baltimore, MD; ³Department of Pediatrics, University of Illinois, Chicago, IL.
Background: T lymphocytes mediate important pathophysiological roles during ischemia reperfusion injury (IRI). Transcription factor Nrf2 is protective during experimental kidney IRI and thought to be…
2015 American Transplant Congress
Lymphotoxin Controls Treg Interactions With Lymphatic Endothelial Cells and Interstitial Migration In Vivo
C. Brinkman, Y. Xiong, S. Ahmad, J. Bromberg.
University of Maryland, Baltimore, MD.
Introduction: Lymphotoxin (LT) coordinates the development, organization and structure of lymphoid organs, and LTβreceptor (LTβR) is involved in thymocyte migration. However, LT has no described…