ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cells"

  • 2016 American Transplant Congress

    Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…
  • 2016 American Transplant Congress

    ASC-Deficient Dendritic Cells Exhibit Activation Defects and a Reduced Ability to Stimulate Allogeneic T Cells.

    A. Scheinok, A. Shigeoka, S. Kasimsetty, R. Elahimehr, D. McKay.

    Medicine, University of California-San Diego, La Jolla, CA.

    Donor dendritic cell (DC) activation causes adaptive immune responses that lead to rejection of transplanted allografts. Accumulating data suggest that inflammasome assembly within interstitial DCs…
  • 2016 American Transplant Congress

    Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.

    J. Espinosa,1,2 M. McRae,1 J. Wang,1 A. Kirk.1

    1Duke University, Durham; 2Emory University, Atlanta.

    Purpose: Infection induces costimulation-resistant memory T cells with heterologous alloreactivity. Rapamycin has been shown to mitigate the effect of these cells in transplant rejection. Previous…
  • 2016 American Transplant Congress

    Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.

    M. Durand,1,2 F. Braza,1 N. Degauque,1 F. Dubois,2 M. Chesneau,1 P. Guérif,1,3 M. Giral,1,3 S. Brouard.1

    1ITUN-INSERM U1064, Nantes, France; 2University of Nantes, Nantes, France; 3Biotherapy Clinical Investigation Center, Nantes, France.

    Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…
  • 2016 American Transplant Congress

    Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.

    Y. Tomita,1 W. Bracamonte-Baran,1 D. Vignali,2 W. Burlingham.1

    1Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI; 2Department of Immunology, University of Pittsburgh, Pittsburgh.

    Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…
  • 2016 American Transplant Congress

    Thymus Is Required for T Cells Reconstitution Following Antibody-Mediated Lymphoablation.

    K. Ayasoufi, R. Fan, A. Valujskikh.

    Cleveland Clinic, Cleveland.

    Antibody-mediated lymphocyte depletion is used as induction therapy in sensitized transplant recipients. Following lymphoablation, peripheral lymphopenia triggers homeostatic T cell proliferation (HP) and enhanced thymopoiesis.…
  • 2016 American Transplant Congress

    Learning from Cancer: Using D-Lactate for Therapeutic Immunosuppression.

    U. Beier,1 J. Jiao,1 H. Xiao,1 A. Angelin,2 D. Wallace,2 M. Levine,3 W. Hancock.4

    1Pediatric Nephrology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; 2Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 3Department of Surgery, University of Pennsylvania, Philadelphia, PA; 4Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Univerisity of Pennsylvania, Philadelphia, PA.

    Accumulation of lactic acid in the tumor microenvironment contributes to local immunosuppressive conditions that weaken anti-tumor immunity. Lactic acid exists as L- and D- optical…
  • 2016 American Transplant Congress

    Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.

    A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
  • 2016 American Transplant Congress

    Preservation of Alloreactive and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.

    J. Schaenman,1 Y. Korin,2 T. Sidwell,2 V. Groysberg,2 J. Gadzhyan,1 E. Lum,1 U. Reddy,1 E. Huang,1 T. Pham,1 G. Danovitch,1 E. Reed,2 S. Bunnapradist.1

    1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Purpose: We set out to investigate the impact of switch from calcineurin inhibitor (CNI) to belatacept on T cell mediated allo- and EBV-specific immunity.Methods: We…
  • 2016 American Transplant Congress

    Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.

    D. Mathern, P. Heeger.

    Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
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