2017 American Transplant Congress
Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Non-Human Primates.
Mixed hematopoietic chimerism is a promising approach to achieving transplantation tolerance. Transient mixed chimerism leads to renal allograft tolerance in about 70% of cynomolgus macaques…2017 American Transplant Congress
Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.
1CRTI UMR1064, INSERM, Nantes, France; 2CRCNA UMR892, INSERM, Nantes, France
Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…2017 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Anatomical Distribution and Prolongs Cardiac Allograft Survival in Sensitized Recipients.
1Immunology, Cleveland Clinic, Cleveland; 2Aeromics, Inc., Cleveland
Aquaporins are water channels present on mammalian cells. We previously reported that aquaporin 4 (AQP4) blockade with small molecule inhibitor AER270/271 significantly prolongs survival of…2017 American Transplant Congress
Generation of Autologous CMV and EBV-Specific T-Cell Lines from Seronegative Patients for Cell Therapy of Opportunistic Infections Following Kidney Transplantation.
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations after kidney transplant are associated with substantial morbidity, especially in seronegative patients. Adoptive immunotherapy using virus-specific T cells…2017 American Transplant Congress
Which Tr1 Is Better for Transplant Tolerance Induction: Comparing the Tr1 Generated by IL-27 or TGF-βplus IL-27.
IL-10 producing T cells (Tr1) are important for the transplant tolerance induction. However, Tr1 can be induced in two methods: IL-27 or TGF-βplus IL-27. We…2016 American Transplant Congress
Learning from Cancer: Using D-Lactate for Therapeutic Immunosuppression.
Accumulation of lactic acid in the tumor microenvironment contributes to local immunosuppressive conditions that weaken anti-tumor immunity. Lactic acid exists as L- and D- optical…2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…2016 American Transplant Congress
Preservation of Alloreactive and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.
Purpose: We set out to investigate the impact of switch from calcineurin inhibitor (CNI) to belatacept on T cell mediated allo- and EBV-specific immunity.Methods: We…2016 American Transplant Congress
Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.
As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
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