2017 American Transplant Congress
High Eomesodermin Expression Correlates with Potent Human Allo-Reactive CD8+ Effector T Cells.
Surgery, University of Pittsburgh, Pittsburgh, PA
BackgroundThe transcription factors Eomesodermin (Eomes) and T-bet are thought to play critical roles in CD8+ effector memory T cell development. However, the role of Eomes…2017 American Transplant Congress
CTLA4-Ig Inhibits Effector CD8+ T Cell Function In Vivo and Rescues Ongoing Acute Allograft Rejection.
1Surgery, University of Chicago, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL
CLTA4-Ig is clinically approved for preventing rejection in kidney transplant recipients but current data suggest that it is less effective for memory T cells, and…2017 American Transplant Congress
EBV-Specific CD8+ T Cells from Pediatric Thoracic vs Abdominal Transplant Recipients Are Shaped Differently by the Chronic EBV Loads with Potential Impact on the Risk of PTLD.
Background: EBV infection and post-transplant lymphoproliferative disorders (PTLD) are life-threatening complications of pediatric solid organ transplantation (Tx). Chronic high EBV viral load (HVL) carriers have…2017 American Transplant Congress
The Inhibitory Effect of Plasma on T Cell Activation: Possible Role of Plasma Exchange in Anti Rejection Therapy.
Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented.Aim: To compare…2017 American Transplant Congress
Pre-Transplant Recipient Transcriptomic Profile May Predict Delayed Graft Function (DGF) in Kidney Transplantation.
Background: DGF is associated with a reduced long-term graft survival. Ischemia-reperfusion damage and donors' features have been always considered as key pathogenic factors in this…2016 American Transplant Congress
The Role and Mechanism of CD40/CD40L Expression on Different T-Cell Subsets.
Background: Several T-cell costimulatory pathways (i.e. CD28:B7 and CD40:CD40L) play a critical role in modulating alloreactivity, but their function on distinct T cell subsets remains…2016 American Transplant Congress
Parameters of Uremia-Associated Premature Ageing of Peripheral T Cells Do Not Predict Infectious Complications After Renal Transplantation.
Background: End-stage renal disease (ESRD) patients have a prematurely aged T-cell system, which may contribute to the uremia-associated immune deficiency. In this study we tested…2016 American Transplant Congress
Immune Response to BK Virus in Renal Transplant Recipients.
Background: The adaptive immune characteristics associated with BK Virus (BKV) infection and control remain incompletely described. In this study we further elucidate the immune response…2016 American Transplant Congress
T-Bet Regulates nTreg Stability and Suppression in an Islet Allograft Model.
University of Maryland, Baltimore.
The transcription factor T-bet endows Treg with properties tosuppress Th1 inflammation. However, the mechanisms by which T-bet controls alloimmune responses are not fully understood. We…2016 American Transplant Congress
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…
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