Articles tagged "T cells"

2017 American Transplant Congress
The Transcription Factor Batf and IRF1 Controls IL-10/IL-27 Expression in Dendritic Cells and Transplant Tolerance Induction.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Objective: To explore the effect of Batf and IRF1 on IL-10/IL-27 expression in DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT…
2017 American Transplant Congress
Impact of T-Cell Depletion on CMV-Specific Memory T and B Cell Homeostatic Proliferation After Kidney Transplantation.
M. Jarque,² S. Luque,² E. Crespo,² E. Melilli,¹ J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; ²Nephrology Laboratory, IDIBELL, Barcelona, Spain
Human CMV infection is the most common opportunistic infection after kidney transplantation, with a negative impact on kidney allograft outcome. Transplant recipients are at higher…
2017 American Transplant Congress
Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.
H. Xu,¹ S. Dahiya,² L. Wang,² T. Akimova,² W. Hancock,^2,4 S. Levin.³
¹Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ³Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Yale School of Medicine, New Haven, CT
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
2017 American Transplant Congress
Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.
J. Assaker, E. Karreci, F. Dotiwala, S. Routray, A. Kurdi, A. Mihali, T. Borges, A. Chandraker, L. Riella, R. Abdi, J. Lieberman, J. Azzi.
Transplantation Research Center, Harvard Medical School, Boston; Boston Children's Hospital, Harvard Medical School, Boston
In this study, we investigated the mechanisms behind the activation induced cell death of human regulatory T cells (Tregs) that can explain their rapid loss…
2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
M. Parkes, P. Halloran, L. Hidalgo.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…
2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
L. Wang,¹ A. Samanta,¹ M. Levine,¹ U. Beier,¹ R. Han,¹ J. Kalin,² E. Holson,³ P. Cole,² W. Hancock.¹
¹Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³Broad Institute, Cambridge, MA
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…
2017 American Transplant Congress
Is Thymic Function Determining Rejection Onset in Heart Transplantation?
A. Sannier,^1,2 R. Dorent,^1,3 M. Le Borgne,¹ N. Stroumza,¹ J. Senemaud,¹ L. Louedec,¹ F. Andreata,¹ A. Gaston,¹ C. Deschildre,¹ P. Nataf,^1,3 A. Couvelard,² G. Caligiuri,¹ A. Nicoletti.¹
¹Inserm U1148, Diderot University, Paris, France; ²Pathology Department, Bichat Hospital, Paris, France; ³Cardiac Surgery Department, Bichat Hospital, Paris, France
The thymus is the primary site of T cell development, involuting into fatty tissue in adults. Thymic function persists in the adulthood and may be…
2017 American Transplant Congress
Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Non-Human Primates.
P. Alonso-Guallart,¹ R. Duran-Struuck,¹ J. Stern,¹ S. Kofman,¹ M. Danton,¹ J. Zitsman,¹ Y. Kato,¹ E. Berglund,¹ H. Sondermeijer,¹ A. McMurchy,² M. Levings,² M. Sykes,¹ A. Griesemer.¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY; ²University of British Columbia, Vancouver, Canada
Mixed hematopoietic chimerism is a promising approach to achieving transplantation tolerance. Transient mixed chimerism leads to renal allograft tolerance in about 70% of cynomolgus macaques…
2017 American Transplant Congress
Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.
T.-M. Doan-Ngoc,¹ G. Tilly,¹ M. Yap,¹ A. Caristan,¹ L. Jacquemont,¹ R. Danger,¹ M. Cadoux,¹ S. Bruneau,¹ M. Giral,¹ P. Guerif,¹ B. Nicol,¹ A. Garcia,¹ D. Laplaud,¹ S. Brouard,¹ C. Pecqueur,² N. Degauque.¹
¹CRTI UMR1064, INSERM, Nantes, France; ²CRCNA UMR892, INSERM, Nantes, France
Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…