Articles tagged "T cells"

2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Yale School of Medicine, New Haven, CT
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
2017 American Transplant Congress
Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.
J. Assaker, E. Karreci, F. Dotiwala, S. Routray, A. Kurdi, A. Mihali, T. Borges, A. Chandraker, L. Riella, R. Abdi, J. Lieberman, J. Azzi.
Transplantation Research Center, Harvard Medical School, Boston; Boston Children's Hospital, Harvard Medical School, Boston
In this study, we investigated the mechanisms behind the activation induced cell death of human regulatory T cells (Tregs) that can explain their rapid loss…
2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
M. Parkes, P. Halloran, L. Hidalgo.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…
2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
L. Wang,¹ A. Samanta,¹ M. Levine,¹ U. Beier,¹ R. Han,¹ J. Kalin,² E. Holson,³ P. Cole,² W. Hancock.¹
¹Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³Broad Institute, Cambridge, MA
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…
2017 American Transplant Congress
Is Thymic Function Determining Rejection Onset in Heart Transplantation?
A. Sannier,^1,2 R. Dorent,^1,3 M. Le Borgne,¹ N. Stroumza,¹ J. Senemaud,¹ L. Louedec,¹ F. Andreata,¹ A. Gaston,¹ C. Deschildre,¹ P. Nataf,^1,3 A. Couvelard,² G. Caligiuri,¹ A. Nicoletti.¹
¹Inserm U1148, Diderot University, Paris, France; ²Pathology Department, Bichat Hospital, Paris, France; ³Cardiac Surgery Department, Bichat Hospital, Paris, France
The thymus is the primary site of T cell development, involuting into fatty tissue in adults. Thymic function persists in the adulthood and may be…
2017 American Transplant Congress
Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Non-Human Primates.
P. Alonso-Guallart,¹ R. Duran-Struuck,¹ J. Stern,¹ S. Kofman,¹ M. Danton,¹ J. Zitsman,¹ Y. Kato,¹ E. Berglund,¹ H. Sondermeijer,¹ A. McMurchy,² M. Levings,² M. Sykes,¹ A. Griesemer.¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY; ²University of British Columbia, Vancouver, Canada
Mixed hematopoietic chimerism is a promising approach to achieving transplantation tolerance. Transient mixed chimerism leads to renal allograft tolerance in about 70% of cynomolgus macaques…
2017 American Transplant Congress
Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.
T.-M. Doan-Ngoc,¹ G. Tilly,¹ M. Yap,¹ A. Caristan,¹ L. Jacquemont,¹ R. Danger,¹ M. Cadoux,¹ S. Bruneau,¹ M. Giral,¹ P. Guerif,¹ B. Nicol,¹ A. Garcia,¹ D. Laplaud,¹ S. Brouard,¹ C. Pecqueur,² N. Degauque.¹
¹CRTI UMR1064, INSERM, Nantes, France; ²CRCNA UMR892, INSERM, Nantes, France
Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…
2017 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Anatomical Distribution and Prolongs Cardiac Allograft Survival in Sensitized Recipients.
M. Nicosia,¹ R. Fan,¹ G. Farr,² M. Pelletier,² P. McGuirk,² K. Ayasoufi,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland; ²Aeromics, Inc., Cleveland
Aquaporins are water channels present on mammalian cells. We previously reported that aquaporin 4 (AQP4) blockade with small molecule inhibitor AER270/271 significantly prolongs survival of…
2017 American Transplant Congress
Generation of Autologous CMV and EBV-Specific T-Cell Lines from Seronegative Patients for Cell Therapy of Opportunistic Infections Following Kidney Transplantation.
C. Lamarche,¹ T. Pincez,¹ J. Orio,¹ C. Carli,¹ A. Humar,² J.-S. Delisle.¹
¹Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; ²Toronto General Research Institute, Toronto, ON, Canada
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations after kidney transplant are associated with substantial morbidity, especially in seronegative patients. Adoptive immunotherapy using virus-specific T cells…
2017 American Transplant Congress
Which Tr1 Is Better for Transplant Tolerance Induction: Comparing the Tr1 Generated by IL-27 or TGF-βplus IL-27.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
IL-10 producing T cells (Tr1) are important for the transplant tolerance induction. However, Tr1 can be induced in two methods: IL-27 or TGF-βplus IL-27. We…