Articles tagged "T cells"

2018 American Transplant Congress
What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls
M. Sosniuk,¹ A. Halpin,^1,2,5,6,7 J. Wizniak,⁷ A. Szkotak,^6,7 S. Urschel,^1,2,5 L. Ionescu,^1,2,5 L. West.^1,2,3,4,5,6
¹Dept of Pediatrics, U of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Dept of MMI, U of Alberta, Edmonton, Canada; ⁴Dept of Surgery, U of Alberta, Edmonton, Canada; ⁵Canadian National Transplant Research Program, National, Canada; ⁶Dept of Laboratory Medicine, U of Alberta, Edmonton, Canada; ⁷Laboratory Medicine and Pathology, Alberta Health Services, Edmonton, Canada.
INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…
2018 American Transplant Congress
Lymphocyte Proportions Post Thymectomy Are Associated with Allergic Disorders in Heart Transplanted Children
T. Kim,¹ L. Ionescu,^1,2,3 N. Avdimiretz,⁴ M. Larsen,^1,2,3 F. Murdoch,^1,2 B. Motyka,^1,2,3 S. Gilmour,^1,2 L. West,^1,2,3 S. Urschel.^1,2,3
¹Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Stollery Children's Hospital, Edmonton, AB, Canada; ³Alberta Transplant Institute, Edmonton, Canada; ⁴The Hospital for Sick Children, Toronto, Canada.
Background: Allergic disorders are more common in pediatric heart transplant (HTx) recipients than non-transplanted children, with young age at HTx and thymectomy being risk factors.…
2018 American Transplant Congress
Metabolic Therapy as a Platform for CTLA4Ig Costimulation Blockade in Preventing Allograft Rejection
C-.H. Cheng,^1,2 C-.F. Lee,^1,2 G. Furtmüller,³ B. Oh,³ C. Patel,¹ Y-.C. Lo,¹ M. Fryer,³ G. Brandacher,³ J. Powell.¹
¹Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, New Taipei City, Taiwan; ³Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
The backbone of current immunosuppression regimens remains calcineurin inhibitors (CNI) in association with steroids, mycophenolate mofetil or mTOR inhibitors. However, their long-term administration is associated…
2018 American Transplant Congress
Preformed Donor-Reactive T-Cells That Persist after ABO Desensitization Independently Predict Severe Acute Cellular Rejection after Living Donor Kidney Transplantation
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapie (BCRT), Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health (BIH), Charite and Max Delbrueck Center, Berlin, Germany.
Donor-reactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute celluar rejection. These donor-reactive memory T-cells rapidly acquire effector…
2018 American Transplant Congress
Leukocytes from Recipients with Severe Primary Graft Dysfunction after Lung Transplant Adoptively Transfer Alloreactivity to Vessel Grafts Trans Vivo
A-.K. Knoefel,¹ T. Siemeni,¹ N. Madrahimov,¹ W. Sommer,¹ M. Avsar,¹ L. Ahrens,¹ I. Tudorache,¹ A. Haverich,¹ C. Falk,² G. Warnecke.¹
¹HTTG, MHH, Hannover, Germany; ²Transplantimmunology, MHH, Hannover, Germany.
Introduction: Primary graft dysfunction (PGD) is the main cause of early mortality after lung transplantation (LTx). Multiple mechanisms have been described, but the link between…
2018 American Transplant Congress
Tregs Expression Predicts Prognosis in Patients with Hepatocellular Carcinoma
A. Baquerizo,¹ V. Vavinskaya,² C. Frenette,¹ M. Nelson,¹ R. Schaffer,¹ J. Fisher,¹ L. Sher,³ B. Madani,¹ P. Pockros,¹ C. Marsh.¹
¹Surgery / Transplant, Scripps Green Hospital, La Jolla, CA; ²Pathology, UCSD, San Diego, CA; ³Surgery / Transplant, USC, Los Angeles, CA.
New therapeutic strategies are needed to improve the survival of patients with hepatocellular carcinoma (HCC), the third in overall global cancer-related mortality. T regulatory cells…
2018 American Transplant Congress
Dependency on CD4 T Cells, Foreign Protein, and CD22 for Generation of Antibody Response to Non-Self Blood Group A-Antigen in a Mouse Model
I. Adam, B. Motyka, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, AB, Canada.
Background: ABO-incompatible heart transplantation (ABOi-HTx) is safe during infancy and allows increased donor access. B cell tolerance develops to donor A/B-antigens (Ag) after ABOi HTx…
2018 American Transplant Congress
T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients
B. Ramaswami,¹ M. Marrari,² O. Yoshida,⁵ X. Guo,³ W. Hoffman,³ C. Bentlejewski,² D. Metes,¹ A. Demetris,^1,2 A. Zeevi,² A. Thomson,¹ G. Mazariegos,⁴ G. Chalasani.^1,3
¹Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ²Pathology, University of Pittsburgh, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA; ⁴Children's Hospital, University of Pittsburgh, Pittsburgh, PA; ⁵Gastroenterology, Ehime University Graduate School of Medicine, Toon-shi, Ehime-ken, Japan.
Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…
2018 American Transplant Congress
Clinical Significance of BK Virus-Specific ELISPOT Assay in Kidney Transplant Recipients
J. Chang,^1,2 H. Bae,³ K. Park,³ H. Lee,³ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y. Kim,^1,2 E-.J. Oh,^1,4 B. Chung.^1,2
¹Transplant Research Center, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ³Department of Biomedical Science, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ⁴Department of Laboratory Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
This study aimed to investigate whether BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BKV…
2018 American Transplant Congress
T Cell Lineage Imbalance and Regulatory Immune Populations in HCC Patients Undergoing Downstaging While Waitlisted for Liver Transplantation
P. Thevenot,¹ K. Nunez,¹ T. Sandow,² J. Gimenez,² J. Gonzalez-Rosario,¹ M. Patel,¹ A. Alfadhli,¹ D. Wyczechowska,³ A. Cohen.¹
¹Institute of Translational Research, Ochsner Health System, New Orleans, LA; ²Interventional Radiology, Ochsner Health System, New Orleans, LA; ³Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Purpose:In this study, we monitored peripheral lymphocyte lineage and regulatory immune populations in HCC patients undergoing DEB-TACE as a bridge to liver transplantation.Methods: Liver transplant…