2018 American Transplant Congress
TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival
Path & Lab Med, CHOP & UPenn, Philadelphia, PA.
Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…2018 American Transplant Congress
Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model
Plastic and Reconstructive Surgery, Shanghai Ninth Hospital, Shanghai, China.
Background: Induction of tolerance and minimizing the toxicity of immuno- suppression are two fundamental goals in vascularized composite allotrans- plantation. Accumulating data indicate that triptolide…2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…2018 American Transplant Congress
Donor Reactive Eomesderminhi CD8+ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection
IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…2018 American Transplant Congress
T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism
Center for Transplant Science, Massachusetts General Hospital, Boston, MA.
Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…2018 American Transplant Congress
Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients
Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…2018 American Transplant Congress
Identification of T Cells as Target of Intervention to Decrease Anti-LG3 Autoantibody Levels Prior to Transplantation
Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Autoantibodies against perlecan/LG3 fragment (anti-LG3) have been associated with accelerated allograft rejection and long-term renal allograft dysfunction. Intriguingly, anti-LG3 are present prior to transplantation in…2018 American Transplant Congress
Ablation of Both mTOR and STAT3 in T Cells Induces Heart Transplant Acceptance in Donor Skin-Sensitized Mice
Allogeneic memory T cell response precludes the induction of transplant acceptance; how this process is regulated at the molecular level remains unclear. Both mTOR and…2018 American Transplant Congress
The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-Ab Locus
Introduction: Our lab has demonstrated that murine kidney allografts are spontaneously accepted in specific donor-recipient strain combinations. Histologic examination of spontaneously accepted DBA/2J (DBA) kidneys…2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
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