Articles tagged "T cells"

2018 American Transplant Congress
Dependency on CD4 T Cells, Foreign Protein, and CD22 for Generation of Antibody Response to Non-Self Blood Group A-Antigen in a Mouse Model
I. Adam, B. Motyka, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, AB, Canada.
Background: ABO-incompatible heart transplantation (ABOi-HTx) is safe during infancy and allows increased donor access. B cell tolerance develops to donor A/B-antigens (Ag) after ABOi HTx…
2018 American Transplant Congress
T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients
B. Ramaswami,¹ M. Marrari,² O. Yoshida,⁵ X. Guo,³ W. Hoffman,³ C. Bentlejewski,² D. Metes,¹ A. Demetris,^1,2 A. Zeevi,² A. Thomson,¹ G. Mazariegos,⁴ G. Chalasani.^1,3
¹Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ²Pathology, University of Pittsburgh, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA; ⁴Children's Hospital, University of Pittsburgh, Pittsburgh, PA; ⁵Gastroenterology, Ehime University Graduate School of Medicine, Toon-shi, Ehime-ken, Japan.
Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…
2018 American Transplant Congress
Clinical Significance of BK Virus-Specific ELISPOT Assay in Kidney Transplant Recipients
J. Chang,^1,2 H. Bae,³ K. Park,³ H. Lee,³ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y. Kim,^1,2 E-.J. Oh,^1,4 B. Chung.^1,2
¹Transplant Research Center, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ³Department of Biomedical Science, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ⁴Department of Laboratory Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
This study aimed to investigate whether BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BKV…
2018 American Transplant Congress
T Cell Lineage Imbalance and Regulatory Immune Populations in HCC Patients Undergoing Downstaging While Waitlisted for Liver Transplantation
P. Thevenot,¹ K. Nunez,¹ T. Sandow,² J. Gimenez,² J. Gonzalez-Rosario,¹ M. Patel,¹ A. Alfadhli,¹ D. Wyczechowska,³ A. Cohen.¹
¹Institute of Translational Research, Ochsner Health System, New Orleans, LA; ²Interventional Radiology, Ochsner Health System, New Orleans, LA; ³Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Purpose:In this study, we monitored peripheral lymphocyte lineage and regulatory immune populations in HCC patients undergoing DEB-TACE as a bridge to liver transplantation.Methods: Liver transplant…
2018 American Transplant Congress
BK Polyomavirus (BKPyV)-Specific T Cells as a Diagnostic and Prognostic Marker for BKPyV-Infections after Pediatric Kidney Transplantation
T. Ahlenstiel-Grunow,¹ M. Sester,² U. Sester,³ L. Pape.¹
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Transplant and Infection Immunology, Saarland University, Homburg, Germany; ³Internal Medicine IV, Saarland University, Homburg, Germany.
After kidney transplantation (KTx) immunosuppressive therapy causes an impaired cellular immune defense resulting in an increased risk of BKPyV-nephropathy (BKPyVAN). Prognostic markers for the outcome…
2018 American Transplant Congress
Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction
J. Wu,^1,2 H. Zhang,¹ X. Shi,¹ X. Xiao,¹ Y. Fan,¹ J. Xia,² R. Sciammas,^1,3 X. Li,^1,3 W. Chen.^1,3
¹Center for Immunobiology & Transplant Science, Houston Methodist Research Institute, Houston, TX; ²Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ³Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…
2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
2018 American Transplant Congress
Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants
H. Xu,¹ Z. Chen,² W. Hancock,^3,4 S. Levin,⁵ Y. Zhang.¹
¹Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; ²Institute of Immunology, University of Pennsylvania, Philadelphia; ³Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; ⁵Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.
Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
2018 American Transplant Congress
T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival
N. Chun,¹ D. Verghese,¹ M. Demir,¹ M. Fribourg,³ I. Llaudo,¹ E. Medof,⁴ P. Heeger.¹
¹Div of Nephrology, Dept of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, NY, NY; ²Dept of Neurology, Icahn School of Medicine at Mount Sinai, NY, NY; ³Dept of Pathology, Case Western Reserve Univ, Cleveland, OH.
C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…
2018 American Transplant Congress
T Cell Exhaustion in Kidney Transplant Patients
M. Fribourg,¹ C. Fischman,² L. Anderson,² B. Burrell,³ P. Heeger,² P. Cravedi.²
¹Department of Neurology, Icahn School of Medicine, New York; ²Department of Medicine, Icahn School of Medicine, New York; ³Immune Tolerance Network, Bethesda.
Background: T cell exhaustion is a dysfunctional state that arises during chronic infection and cancer in response to persistence of high antigenic load. Whether chronic…