Articles tagged "T cells"

2018 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Trafficking through a Novel Mechanism of S1PR1 Regulation
M. Nicosia,¹ R. Fan,¹ S. Miyairi,¹ A. Beavers,¹ G. Farr,² P. McGuirk,² M. Pelletier,² A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics LLC, Cleveland, OH.
The ubiquitous water channels aquaporins mediate a variety of immune functions. We previously demonstrated that aquaporin 4 (AQP4) is expressed by CD4 and CD8 T…
2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Y. Liu, Y. Dong, D. Mathews, A. Ghosh, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…
2018 American Transplant Congress
Lymphatic Endothelium Requires S1PR2 for T Cell Transendothelial Migration
Y. Xiong,¹ W. Piao,¹ C. Brinkman,¹ L. Li,¹ J. Kulinski,² A. Olivera,² A. Cartier,³ T. Hla,³ S. Schwab,⁴ K. Hippen,⁵ B. Blazar,⁵ J. Bromberg.¹
¹UMB, MD; ²NIH, MD; ³Boston Children's Hospital, MA; ⁴NYU, NY; ⁵U. Minnesota, MN.
Introduction: Sphingosine 1-phosphate (S1P) receptors 1 (S1PR1) and S1PR2 are highly expressed by lymphatic endothelial cells (LEC), while T cells express S1PR1 and S1PR4. S1P…
2018 American Transplant Congress
CD4⁺CD25^bright Regulatory T Cells Prevent Acute Xenogeneic GVHD
Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
2018 American Transplant Congress
Treg Regulate Distinct Lymphatic NFκB Signaling Pathways to Alter Migration and Immunity
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, MD.
Background: Treg migration to the graft and draining lymph nodes is crucial for graft survival. Little is known about the molecular cues that regulate the…
2018 American Transplant Congress
Differential Effects of Inhibiting Glycolysis on Human Treg Subsets
N. Tanimine, B. Priyadharshini, S. Germana, L. Turka.
Department of Surgery, Massachusetts General Hospital, Boston, MA.
Regulatory T cells (Tregs) are a promising therapeutic tool for inducing transplantation tolerance. Tregs can be divided into those of thymic origin (tTreg) and those…
2018 American Transplant Congress
Emergence of a Costimulation-Susceptible T Cell Repertoire Post-Alemtuzumab Induction
Q. Gao,¹ A. Mehta,² A. Guasch,² L. Stempora,¹ A. Kirk,¹ H. Xu.¹
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.
Kidney transplant patients treated with belatacept-based regimens without depletional induction have higher rates of costimulation blockade resistant rejection (CoBRR). In contrast, belatacept effectively prevents rejection…
2018 American Transplant Congress
Vendor-Specific Differences in Identical Strains of Mice Yield Dichotomous Result in Lung Allograft Rejection
Y. Guo, Q. Wang, O. Onyema, A. Gelman, D. Kreisel, A. Krupnick.
Surgery, University of Virginina, Charlottesville, VA; Surgery, Washington University in St. Louis, St. Louis, MO.
Intro: Orthotropic transplantation of murine lung allografts has paved the way for mechanistic studies of pulmonary tolerance and rejection but discrepancies have been reported by…
2018 American Transplant Congress
Immunomonitoring of Operational Tolerance in Intestinal Transplantation
O. Aguirre, B. Houlihan, T. Fishbein, A. Kroemer.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
2018 American Transplant Congress
Central Role of Mef2 Transcription Factors in Regulation of Foxp3 Expression and Treg Function
A. Samanta,¹ L. Wang,¹ R. Han,¹ W. Hancock.^1,2
¹CHOP, Philadelphia; ²UPenn, Philadelphia.
Foxp3+ Tregs express 4 class IIa Hdac enzymes (Hdac4, 5, 7 & 9) with little or no catalytic activity and yet when deleted, at least…