Articles tagged "T cells"

2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's, Boston, MA, ⁵U.Minnesota, Minneapolis, MN, ⁶U.Minnesota, Minneapolis, MD, ⁷NYU, NY, NY
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…
2019 American Transplant Congress
Granulocyte – Colony Stimulating Factor (G-CSF) and Granulocyte – Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates
K. Sasaki, Y. Wang, L. Lu, J. Hughs, A. W. Thomson, M. B. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are known to mobilize immune cells to the peripheral blood. We evaluated regulatory T cells (Treg)…
2019 American Transplant Congress
RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection
B. Dooley¹, A. Verma², R. Ding¹, C. Li¹, C. Snopkowski¹, H. Yang¹, B. Botticelli¹, S. Albakry¹, E. Edusei¹, T. Muthukumar¹, M. Lubetzky¹, D. Dadhania¹, J. Lee¹, O. Elemento², M. Suthanthiran¹
¹Transplantation Medicine, Weill Cornell Medical College, New York, NY, ²Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY
*Purpose: T cell help is essential for B cell production of antibodies to donor organ HLA. Because T cell-B cell interactions contribute to anti-allograft immunity,…
2019 American Transplant Congress
Store-Operated/Calcium Release Activated Calcium Channel Orai3 is a Novel Target for Immunoregulation
D. Shankaranarayanan¹, M. Lagman¹, V. Sharma¹, C. Li¹, M. Cassidy¹, C. Snopkowski¹, H. Yang¹, T. Muthukumar¹, K. Machaca², M. Suthanthiran¹
¹WCMC, New York, NY, ²WCMC, Doha, Qatar
*Purpose: Store-operated/calcium release activated calcium (CRAC) channels are essential for the signaling of immune cells via calcineurin, a calcium-calmodulin dependent serine-threonine phosphatase. The central importance…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
Adipose Stem Cells Promote Composite Tissue Engraftment
N. Shockcor¹, B. Buckingham¹, W. Hassanein¹, D. Parsell¹, U. Dhru¹, B. Akinsiku², E. Elster², T. Davis², J. Gimble³, A. Nam¹, S. Bartlett¹, R. Barth¹
¹Surgery, University of Maryland, Baltimore, MD, ²Uniformed Services University of the Health Sciences, Bethesda, MD, ³LaCell LLC, New Orleans, LA
*Purpose: Adipose-derived stem cells (ASC) have increased levels of anti-inflammatory and immunoregulatory factors. Murine studies have shown stable macrochimerism and long-term full thickness skin graft…
2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴
¹Department of Urological Organ Transplantation, The Second Xiangya Hospital, Central-South University, Changsha, China, ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Biostatistics, Graduate School of Public Health, and Departments of Pharmacology and P, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…
2019 American Transplant Congress
Effects of Thalidomide and Dexamethasone Co-Treatment on CD8⁺ T Cells
J. Kim¹, E. Kim², Y. Cho¹, H. Lee¹, M. Kim³, Y. Kim³, K. Huh³, B. Kim⁴
¹The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ²Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Nephrology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
*Purpose: Thalidomide (TM) is known to have anti-cancer and anti-inflammatory effects and dexamethasone (DX) has been reported that it also reduces inflammation and inhibits inflammatory…
2019 American Transplant Congress
In Vivo Treg Expansion under Costimulation Blockade Targets Early Rejection and Improves Long-Term Outcome
C. Schwarz¹, B. Mahr², L. Unger¹, N. Pilat², H. Regele³, T. Wekerle²
¹Dept. of Surg. / Div. of Transplantation, Medical University Vienna, Vienna, Austria, ²Dept. of Surg. / Section of Transplantation Immunology, Medical University Vienna, Vienna, Austria, ³Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria
*Purpose: Early rejection episodes are a major problem under CTLA4Ig/belatacept-based immunosuppression. We have previously shown that CTLA4Ig therapy is dependent on Tregs at low (LD)…
2018 American Transplant Congress
Differential Effects of Inhibiting Glycolysis on Human Treg Subsets
N. Tanimine, B. Priyadharshini, S. Germana, L. Turka.
Department of Surgery, Massachusetts General Hospital, Boston, MA.
Regulatory T cells (Tregs) are a promising therapeutic tool for inducing transplantation tolerance. Tregs can be divided into those of thymic origin (tTreg) and those…