Articles tagged "T cells"

2019 American Transplant Congress
FcγRIIB is a Novel CD8⁺Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
A. B. Morris¹, D. F. Pinelli¹, D. Liu¹, J. M. Boss², C. D. Scharer², M. Fribourg³, P. Cravedi³, P. S. Heeger³, M. L. Ford¹
¹Surgery, Emory University, Atlanta, GA, ²Micro & Immuno, Emory University, Atlanta, GA, ³Center for Translational Transplant Research, Icahn SOM at Mount Sinai, New York, NY
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…
2019 American Transplant Congress
The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection
N. M. van Besouw¹, L. Yan¹, R. de Kuiper¹, M. Klepper¹, D. Reijerkerk¹, M. Dieterich¹, D. L. Roelen², F. H. Claas², M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands, ³Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
*Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…
2019 American Transplant Congress
Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates
A. Perez Gutierrez¹, A. W. Thomson², D. M. Metes², M. B. Ezzelarab²
¹Transplantation Institute, University of Chicago Medicine, Chicago, IL, ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…
2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
V. Saxena¹, Y. Xiong¹, L. Hittle¹, L. Li¹, T. Simon², W. Piao¹, C. C. Brinkman¹, E. M. Smyth¹, T. Zhang¹, C. Wagner¹, C. M. Palusckievicz¹, W. F. Fricke³, E. F. Mongodin¹, J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS, Valbonne, France, ³Institute of Biological Chemistry and Nutrition, U Hohenheim, Stuttgart, Germany
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…
2019 American Transplant Congress
Antibody-Suppressor CD8⁺ T Cells Require CXCR5
J. Zimmerer¹, B. A. Ringwald¹, C. L. Avila¹, S. M. Elzein¹, R. T. Warren¹, M. Abdel-Rasoul², G. L. Bumgardner¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…
2019 American Transplant Congress
Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells
J. F. Kuehne¹, R. Ballmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. A. Bläsing¹, F. Ius², A. Knoefel², I. Tudorache², M. Avsar², D. Jonigk³, A. Haverich², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany, ³Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany
*Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
2019 American Transplant Congress
Extracorporeal Photopheresis for Specific Immune Tolerance Responses in Heart Transplant Recipients
M. J. Barten¹, K. Klaeske², J. Wittke², M. Borger², J. Garbade², S. Lehmann³, H. Reichenspurner¹, M. Dieterlen²
¹Cardiovascular Surgery, University Heart Center, Hamburg, Germany, ²Cardiac Surgery, University Heart Center Leipzig, Leipzig, Germany, ³Cardiacr Surgery, University Heart Center Leipzig, Leipzig, Germany
*Purpose: Extracorporeal photopheresis (ECP) treatment following heart transplantation (HTx) may induce transplant tolerance. A monitoring tool for successful ECP treatment would allow determination of patient-specific…
2019 American Transplant Congress
Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo
Y. Xiong, L. Wang, R. Han, W. W. Hancock
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
2019 American Transplant Congress
Graft-Infiltrating Regulatory T Cells Are Associated with Long Term Cardiac Xenograft Survival
A. K. Singh¹, G. Braileanu¹, A. Hersfield¹, L. DiChiacchio¹, T. Zhang¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, School of Medicine, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
P. Porrett,¹ J. Cohen,² R. Xu,¹ E. Lewis,³ M. Elovitz,³ E. Wherry,⁴ D. Sawinski.²
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³OBGyn, University of Pennsylvania, Philadelphia, PA; ⁴Microbiology, University of Pennsylvania, Philadelphia, PA.
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…