2019 American Transplant Congress
Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…2019 American Transplant Congress
Human Adenovirus-Specific T Cell Response in Kidney Transplant Recipients Diagnosed with Adenovirus Infection
*Purpose: Cell-mediated immunity plays an important role in controlling human adenovirus (HAdV) infection after kidney transplantation (KT). We investigated T cell lymphocyte subsets and HAdV-specific…2019 American Transplant Congress
Cd45rb Mediates Cd8+T Cell Persistence In An Allogeneic Heterologous Immune Response
Emory Transplant Center, Atlanta, GA
*Purpose: Memory T cells primed with microbial antigen can cross-react with alloantigen and mediate graft rejection, a process termed allogeneic heterologous immunity. Human and murine…2019 American Transplant Congress
The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung Perfusion
*Purpose: The appearance of passenger donor lymphocytes in recipient blood after double lung transplantation has been described decades ago. However, neither their early kinetics, nor…2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…2019 American Transplant Congress
Bespoke Immunosuppression: Prolonging Transplant Survival through Enhanced T-cell Activation Induced Cell Death
*Purpose: We aim to develop donor-specific immunosuppression by inhibiting T-cell cellular FLICE like inhibitory protein (c-FLIP). Our current work focuses on clinically relevant pharmacological inhibitors…2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…2019 American Transplant Congress
Granulocyte – Colony Stimulating Factor (G-CSF) and Granulocyte – Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates
*Purpose: Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are known to mobilize immune cells to the peripheral blood. We evaluated regulatory T cells (Treg)…2019 American Transplant Congress
RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection
*Purpose: T cell help is essential for B cell production of antibodies to donor organ HLA. Because T cell-B cell interactions contribute to anti-allograft immunity,…2019 American Transplant Congress
Store-Operated/Calcium Release Activated Calcium Channel Orai3 is a Novel Target for Immunoregulation
1WCMC, New York, NY, 2WCMC, Doha, Qatar
*Purpose: Store-operated/calcium release activated calcium (CRAC) channels are essential for the signaling of immune cells via calcineurin, a calcium-calmodulin dependent serine-threonine phosphatase. The central importance…
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