2022 American Transplant Congress
Immune Checkpoints, Immune Cells, and MHC Expression in the Tumor Microenvironment of Resected Hepatocellular Carcinomas
*Purpose: Advances in tumor biology has shown the important role of the tumor microenvironment (TME) in tumor growth and metastasis. A better understanding of the…2022 American Transplant Congress
Treg Tissue Stability Depends on Adenosine Receptor Driven Lymphatic Endothelial Cell Responses
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Migrating Tregs were…2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…2022 American Transplant Congress
Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation
Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…2022 American Transplant Congress
Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health
1Stanford University, Palo Alto, CA, 2Rho, Durham, NC, 3National Institutes of Health, Bethesda, MD
*Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…2022 American Transplant Congress
Impact of Immunosuppression on T-cell Responses After mRNA-Based Sars-CoV-2 Vaccination
*Purpose: Administration of mRNA-based SARS-CoV-2 vaccines confers protection from SARS-CoV-2 infection and reduces its severity in the general population. It has been suggested that mounting…2022 American Transplant Congress
Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance
*Purpose: New therapeutic approaches to the management of transplant recipients are warranted in efforts to improve outcomes.*Methods: We have engineered a modified human IL-2 protein…2022 American Transplant Congress
Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles
*Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…2022 American Transplant Congress
Early Clinical Experience With Alvr109, A Partially Hla-matched Sars-cov-2 Specific T-cell Therapy, In Immunocompromised Patients With Covid-19
1University of Pittsburgh, Pittsburgh, PA, 2UPitt, Pittsburgh, PA, 3Allovir, Waltham, MA
*Purpose: Therapies for COVID-19 in immunocompromised (IC) patients (pts), including transplant (tx) pts, are limited. We describe our experience with ALVR109, an allogeneic, partially HLA-matched…
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