Articles tagged "T cells"

2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
2020 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2020 American Transplant Congress
PD-L1 Signals Lymphatic Endothelium for Treg Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena³, Y. Xiong¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar², L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²Pediatrics, U of Minnesota, Minneapolis, MN, ³U of Maryland, Baltimore, MD, ⁴Transplantation Research Center, Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) migration is important for tolerance, although the molecules that regulate Treg entry to lymphatics are poorly understood. Lymphatic endothelial cells…
2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
B. Kim¹, E. Kim², J. Kim², H. Choi³, H. Lee², J. Lee⁴, M. Kim⁴, Y. Kim⁴, K. Huh⁴
¹Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
2020 American Transplant Congress
Determination of Programmed Cell Death Protein 1 (PD1) by Flow Cytometry, a Possible Follow-Up Tool in Renal Transplantation of High Immune Risk
M. Carmona-Escamilla¹, M. Fonseca², J. Prieto Chávez³, L. Arriaga⁴, F. Oviendo⁵, S. , Hernández-Mendoza SA², J. Alberu⁶, G. Queipo²
¹Nephrology, Hospital Central Sur Alta Especialidad "Picacho", CDMX, Mexico, ²Genetics, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ³Transplant, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ⁴Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, CDMX, Mexico, ⁵Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, Ciudad de México, México, CDMX, Mexico, ⁶Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico
*Purpose: Introduction: Currently, the follow-up of patients remains to be the serum creatinine level, being highly specific, however, with little sensitivity to determine the occurrence…
2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…
2020 American Transplant Congress
Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8⁺ T Cells
A. B. Morris, D. F. Pinelli, D. Liu, M. L. Ford
Emory University, Atlanta, GA
*Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…
2020 American Transplant Congress
Feasibility and Long Term Safety of T Regulatory Cell Therapy in Kidney Transplantation
P. N. Harden¹, D. Game², J. Van der Net¹, F. Issa³, W. Petchey¹, M. Brook¹, P. Friend¹, R. Hilton⁴, G. Lombardi⁵, K. Wood³
¹Kidney Transplantation, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, ²Kidney Transplantation, Guys and St Thomas's Hospital, London, United Kingdom, ³Transplant Immunology Research Group, Oxford University, Oxford, United Kingdom, ⁴Kidney Transplantation, Guys and St Thomas's Hospital, Oxford, United Kingdom, ⁵Transplant Immunology Group, Kings Healthcare Partners, London, United Kingdom
*Purpose: A sequential clinical trial of autologous polyclonal T regulatory cellular therapy compared with a standardised reference cohort of live donor kidney transplant recipients. The…