Articles tagged "T cells"

2021 American Transplant Congress
The Importance of Persistent and Recurrent T Cell Mediated Rejection in Tacrolimus Treated Renal Transplant Recipients
C. Rampersad¹, I. W. Gibson², D. N. Rush¹, D. Pochinco³, P. E. Birk⁴, A. Goldberg⁴, T. Blydt-Hansen⁵, M. Karpinski¹, J. Shaw¹, J. Ho¹, P. W. Nickerson¹, C. Wiebe¹
¹Department of Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Department of Pathology, University of Manitoba, Winnipeg, MB, Canada, ³Shared Health Services Manitoba, Winnipeg, MB, Canada, ⁴Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Department of Pediatrics, University of British Columbia, Winnipeg, MB, Canada
*Purpose: Optimal follow-up after treatment for T-cell mediated rejection (TCMR) is not well-established. We sought to identify the prevalence and clinical associations of repeated TCMR…
2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
A. C. van der List, N. H. Litjens, M. G. Betjes, M. Klepper
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…
2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
A. Malone, A. Leckie-Harre, I. Silverman, A. Chadha, H. Wu, B. Humphreys
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…
2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
T. Ahlenstiel-Grunow¹, X. Liu², R. Schild³, J. Oh³, C. Taylan⁴, L. T. Weber⁴, H. Staude⁵, M. Verboom⁶, C. Schröder⁷, R. Sabau⁷, A. Großhennig², L. Pape¹
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Institute of Biostatistics, Hannover Medical School, Hannover, Germany, ³Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ⁴Pediatric Nephrology, University of Colgne, Köln, Germany, ⁵Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, ⁶Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, ⁷Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…
2021 American Transplant Congress
Establishing a Linear Program for the Development of Costimulation Resistant T-Cells
D. P. Moris, A. Lucander, A. Kirk
Surgery, Duke, Durham, NC
*Purpose: CD4+CD57+PD1-T-cells are primed effectors capable of mediating belatacept-resistant rejection, however, the developmental program giving rise to these cells has not been elucidated in detail.…
2021 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure
V. Saxena¹, W. Piao¹, L. Li¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
2021 American Transplant Congress
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells
A. B. Morris, E. Peek, A. Hadley, C. P. Larsen
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…
2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
2020 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…