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American Transplant Congress abstracts

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Articles tagged "T cells"

  • 2021 American Transplant Congress

    CEACAM1 Signaling is Essential to Elicit Tim-3 Inhibitory Regulation in Liver Transplantation

    H. Kojima, H. Hirao, T. Ito, K. Kadono, K. J. Dery, F. M. Kaldas, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: T cell immunoglobulin domain and mucin domain-3 (TIM-3) has been reported to induce T cell exhaustion. By alleviating hepatic ischemia-reperfusion injury, we have explored…
  • 2021 American Transplant Congress

    Evaluation of the Differentiation Program of Endogenous Antigen-specific CD8+T Cells Following Transplantation

    S. M. Krummey1, K. Tong2, M. L. Ford2

    1Pathology, Johns Hopkins University, Baltimore, MD, 2Surgery, Emory Transplant Center, Atlanta, GA

    *Purpose: Despite advances in the survival of transplanted organs, acute T cell mediated rejection remains a significant clinical problem with few effective or targeted treatments.…
  • 2021 American Transplant Congress

    The Importance of Persistent and Recurrent T Cell Mediated Rejection in Tacrolimus Treated Renal Transplant Recipients

    C. Rampersad1, I. W. Gibson2, D. N. Rush1, D. Pochinco3, P. E. Birk4, A. Goldberg4, T. Blydt-Hansen5, M. Karpinski1, J. Shaw1, J. Ho1, P. W. Nickerson1, C. Wiebe1

    1Department of Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Department of Pathology, University of Manitoba, Winnipeg, MB, Canada, 3Shared Health Services Manitoba, Winnipeg, MB, Canada, 4Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, 5Department of Pediatrics, University of British Columbia, Winnipeg, MB, Canada

    *Purpose: Optimal follow-up after treatment for T-cell mediated rejection (TCMR) is not well-established. We sought to identify the prevalence and clinical associations of repeated TCMR…
  • 2021 American Transplant Congress

    TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation

    A. C. van der List, N. H. Litjens, M. G. Betjes, M. Klepper

    Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands

    *Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…
  • 2021 American Transplant Congress

    Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only

    A. Malone, A. Leckie-Harre, I. Silverman, A. Chadha, H. Wu, B. Humphreys

    Washington University School of Medicine, St Louis, MO

    *Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…
  • 2021 American Transplant Congress

    Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial

    T. Ahlenstiel-Grunow1, X. Liu2, R. Schild3, J. Oh3, C. Taylan4, L. T. Weber4, H. Staude5, M. Verboom6, C. Schröder7, R. Sabau7, A. Großhennig2, L. Pape1

    1Pediatrics II, University Hospital of Essen, Essen, Germany, 2Institute of Biostatistics, Hannover Medical School, Hannover, Germany, 3Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, 4Pediatric Nephrology, University of Colgne, Köln, Germany, 5Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, 6Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, 7Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany

    *Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…
  • 2021 American Transplant Congress

    Establishing a Linear Program for the Development of Costimulation Resistant T-Cells

    D. P. Moris, A. Lucander, A. Kirk

    Surgery, Duke, Durham, NC

    *Purpose: CD4+CD57+PD1-T-cells are primed effectors capable of mediating belatacept-resistant rejection, however, the developmental program giving rise to these cells has not been elucidated in detail.…
  • 2021 American Transplant Congress

    Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
  • 2021 American Transplant Congress

    K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells

    A. B. Morris, E. Peek, A. Hadley, C. P. Larsen

    Emory Transplant Center, Emory University, Atlanta, GA

    *Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…
  • 2021 American Transplant Congress

    Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury

    H. Jin, M. Li, C. Zhang, G. Sun, D. Zhang

    Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…
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