Articles tagged "T cell receptors (TcR)"

2016 American Transplant Congress
End Stage Renal Disease Patients Have a Skewed T Cell Receptor Vbeta Repertoire.
L. Huang,¹ A. Langerak,² I. Wolvers - Tettero,² R. Meijers,¹ C. Baan,¹ N. Litjens,¹ M. Betjes.¹
¹Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; ²Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
IntroductionEnd stage renal disease (ESRD) is associated with a defective T-cell mediated immunity, resembling premature T-cell ageing. A diverse T-cell receptor Vbeta (TCR Vβ) repertoire…
2016 American Transplant Congress
Analysis of T Cell Receptor Repertoire in Routine Renal Allograft Biopsy.
R. Reindl-Schwaighofer,¹ J. Weinberger,¹ R. Jimenez-Heredia,¹ J. Sunzenauer,¹ S. Schaller,² S. Winkler,² R. Oberbauer.¹
¹Department of Nephrology, Medical University of Vienna, Vienna, Austria; ²Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg, Austria.
Introduction: Diversity and clonality of the T cell repertoire of circulating and tissue-resident T-cells can be assessed by sequencing of recombined T cell receptor (TCR)…
2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
T. Savage,¹ S. Dewolf,¹ A. Obradovic,¹ S. Lau,¹ J. Zuber,¹ L. Turka,^2,3 Y. Shen,¹ M. Sykes.¹
¹Columbia University, New York; ²Massachusetts General Hospital, Boston; ³Immune Tolerance Network, Boston.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…
2015 American Transplant Congress
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+ T Cells During Heterologous Immunity
S. Krummey,¹ C.-W. Chen,¹ D. Liu,¹ M. Wagener,¹ B. Evavold,² C. Larsen,¹ M. Ford.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²Microbiology and Immunology, Emory University, Atlanta, GA.
Heterologous immunity, defined as a process during which microbe-specific T cells cross-react with allogeneic antigen and mediate graft rejection, is recognized as a significant barrier…
2015 American Transplant Congress
T Cell Receptor Repertoire Analysis of BKV-Specific T Cells in Peripheral Blood Samples By Next Generation Sequencing Reveals Differential Role and Kinetics of CD4 and CD8 T Cell Clones in Viral Control
M. Nienen,¹ W. Benjamin,¹ L. Kuchenbecker,^1,2,3 J. Hecht,¹ P. Reinke,^1,4 A. Neumann,¹ N. Babel.^1,4
¹Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany; ²Department of Computer Science, Free University, Berlin, Germany; ³Max Planck Institute for Molecular Genetics, Berlin, Germany; ⁴Charite University-Medicine, Berlin, Germany.
Background:BKV-specific T cells play the crucial role in controlling virus reactivation and analyses of their frequencies have been previously performed in different studies. However, nothing…
2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
C. Dorr,¹ B. Wu,² W. Guan,² A. Muthusamy,¹ K. Sanghavi,³ P. Jacobson,³ W. Oetting,³ D. Schladt,¹ R. Remmel,³ J. Maltzman,⁵ A. Matas,⁴ For DeKAF Genomics Investigators,¹ A. Israni.¹
¹Medicine, MMRF, HCMC, Minneapolis, MN; ²Biostatistics, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Surgery, University of MN, Minneapolis, MN; ⁵Medicine, University of PA, Philadelphia, PA.
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…