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Articles tagged "T cell reactivity"

  • 2015 American Transplant Congress

    B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation

    J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.

    Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.

    Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
  • 2015 American Transplant Congress

    Induction of a Costimulation-Susceptible Repertoire: A Case for Depletional Prior to Belatacept

    H. Xu,1 K. Samy,1 A. Guasch,2 S. Mead,2 A. Kirk.1

    1Surgery, Duke University, Durham, NC; 2Transplant Center, Emory University, Atlanta, GA.

    Belatacept offers highly specific costimulation blockade to prevent recipient alloimmune responses with reduced toxicity. However, when applied with nondepletional induction therapy belatacept-based regimens have higher…
  • 2015 American Transplant Congress

    Vaccine-Induced 'Incognito' CD8+ T Cell Memory Can Disrupt Transplantation Tolerance

    M. Nelsen,1 K. Beard,2 R. Kedl,1 R. Gill.2

    1Dept of Immunology & Microbiology, Univ of Colorado, Aurora, CO; 2Dept of Surgery, Univ of Colorado, Aurora, CO.

    Transplant recipients harbor immunity to vaccines and pathogens (e.g. CMV, EBV). Pre-existing immunity can have significant antigen-specific ramifications, usually attributed to heterologous immunity, as pathogen-reactive…
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