Articles tagged "T cell reactivity"

2015 American Transplant Congress
IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins
L. McLaughlin,¹ K. Shiu,¹ G. Lombardi,¹ J. Spencer,² R. Vaughan,¹ A. Dorling.¹
¹MRC Centre for Transplantation, King's College London, London, United Kingdom; ²Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom.
Chronic antibody mediated rejection (CAMR) is a major cause of graft loss in renal transplant recipients. Previous work utilising an IFNγ ELISPOT assay revealed two…
2015 American Transplant Congress
Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection
S. Iida,¹ T. Suzuki,² K. Tanabe,¹ A. Valujskikh,³ R. Fairchild,³ R. Abe.²
¹Urology, Tokyo Women's Medical Univ, Tokyo, Japan; ²Immunology, Science University of Tokyo, Chiba, Japan; ³Immunology, Cleveland Clinic, Cleveland, OH.
【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
2015 American Transplant Congress
miR-155 Different Roles in UCB iTreg and nTreg
Y. Lu, L. Lu.
Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…