ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2017 American Transplant Congress

    Pre-Transplant CMV-Specific T-Cell Immunity Is an Additional Independent Variable Predicting CMV Infection After Kidney Transplantation.

    E. Crespo,1 M. Jarque,1 S. Luque,1 E. Melilli,2 A. Manonelles,2 S. Gil-Vernet,2 J. Cruzado,2 J. Grinyó,2 O. Bestard.2

    1Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain

    Background: Current pre-transplant risk stratification for Cytomegalovirus (CMV) infection is based on donor/recipient (D/R) IgG-serostatus and clinical variables such as the use of T-cell depletion…
  • 2017 American Transplant Congress

    BK Polyomavirus-Specific 9mer T-Cell Responses Predict Control of Viremia in Kidney Transplant Recipients: First Report from the Swiss Transplant Cohort Study.

    H. Hirsch,1 C. Leboeuf,1 S. Wilk,1 R. Achermann,2 I. Binet,3 D. Golshayan,2 K. Hadaya,2 C. Hirzel,2 M. Hoffmann,2 U. Huynh-Do,2 M. Koller,2 O. Manuel,2 N. Mueller,2 T. Mueller,2 S. Schaub,2 C. Van Delden,2 F. Weissbach.1

    1University of Basel, Basel, Switzerland; 2Swiss Transplant Cohort Study, Basel, Switzerland; 3Cantonal Hospital St Gallen, St Gallen, Switzerland

    BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen KT patients for BKPyV viremia…
  • 2017 American Transplant Congress

    FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.

    Y. Tanaka, V. Sapana, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    (Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…
  • 2017 American Transplant Congress

    IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-CMV IgG, Resulting in Inhibition of Antibody (Ab)-Mediated NK Cell Activation in Kidney Transplant Patients (KTX Pts).

    B.-H. Shin,1 S. Ge,1 M. Chu,1 J. Choi,1 L. Winstedt,2 C. Kjellman,2 S. Louie,1 A. Vo,1 A. Peng,1 S. Jordan,1 M. Toyoda.1

    1Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Hansa Medical, Lund, Sweden

    Background: Viral infections represent significant morbidity factors for KTx Pts. Ab-dependent cell-mediated cytotoxicity (ADCC) is a major pathway to eliminate virally infected cells and is…
  • 2017 American Transplant Congress

    Transplantation of Chimeric Cells of Myoblast and Mesenchymal Stem Cell Origin for Restoration of Muscle Function.

    M. Siemionow, E. Szilagyi, J. Cwykiel, A. Domaszewska-Szostek, A. Heydemann, J. Garcia-Martinez.

    University of Illinois at Chicago, Chicago

    Background: Allogeneic stem cell therapies aim to restore muscle tissue after traumatic loss or muscular dystrophies. Limited engraftment due to rejection is a major challenge.…
  • 2017 American Transplant Congress

    Assessment of Donor-Reactive T-Cell Immunity by the Novel Urine Cell-Derived Alloantigen Assay Allows Prediction of Acute Rejection in Renal Transplant Patients.

    C. Thieme,1 B. Weist,1 A. Müskes,1 P. Reinke,1 T. Westhoff,2 N. Babel.1,2

    1BCRT (Berlin-Brandenburg Center for Regenerative Therapies), Berlin, Germany; 2Ruhr University Bochum, Bochum, Germany

    Presensitization and donor-specific immunity play a major role in acute and chronic rejection of kidney transplant patients. While assessment of humoral sensitization is well standardised…
  • 2017 American Transplant Congress

    CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.

    S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.

    The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA

    Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…
  • 2017 American Transplant Congress

    Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.

    M. Iglesias, A. Arun, B. Lam, W. Lee, G. Raimondi, G. Brandacher.

    Plastic Surgery, Johns Hopkins University. School of Medicine, Baltimore, MD

    PurposeA growing body of experimental evidence shows that engagement of toll like receptors (TLR) can abrogate or revert the tolerogenic effect of “costimulation blockade” in…
  • 2017 American Transplant Congress

    Phenotypic and Functional Assessment of T Cell Alloimmunity After Liver Transplantation.

    T. Taner, M. Hansen, W. Park, M. Stegall.

    Mayo Clinic, Rochester, MN

    In addition to its metabolic functions, the liver is also an immunologically active organ. Liver transplant recipients are often maintained on less immunosuppression when compared…
  • 2017 American Transplant Congress

    Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?

    A. Zimmer,1 R. Razonable.2

    1Infectious Diseases, University of Nebraska Medical Center, Omaha, NE; 2Transplant Center, Mayo Clinic, Rochester, MN

    Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…
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