2017 American Transplant Congress
Phenotypic and Functional Assessment of T Cell Alloimmunity After Liver Transplantation.
In addition to its metabolic functions, the liver is also an immunologically active organ. Liver transplant recipients are often maintained on less immunosuppression when compared…2017 American Transplant Congress
Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?
Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…2017 American Transplant Congress
Loss of Bat3 Could Promote Transplant Tolerance by Regulating CD4 + T Cells Function.
Objective: To explore the effect of Bat3 on T cells and its function in transplant tolerance inductionMethodsWe generated Bat3flox/flox CD4-Cre + mice, sorted WT and…2017 American Transplant Congress
CD4+CD28null T Cells Require IL-15 & IL-21 to Become Alloresponsive.
IntroductionAgeing and a pro-inflammatory milieu, such as present in patients with end-stage renal disease, are important drivers of increased T-cell differentiation, which is accompanied by…2017 American Transplant Congress
A Prospective Observational Study to Evaluate Use of a Panel of Reactive T Cell (PRT) Assay as a Pre-Transplant Marker of Rejection in Kidney Transplant Recipients.
Background:To assess risk of T cell mediated acute rejection a recently developed assay uses a panel of reactive T cell lines (PRT) to measure recipient…2017 American Transplant Congress
Prospective Randomized Trial for Predicting CMV Infection According to Baseline CMV-Specific T-Cell Immunity in Kidney Transplant Patients.
Background: Despite the use of either anti-viral prophylaxis (PF) or preemptive (PE) therapy given based on donor/recipient IgG-serostatus, Cytomegalovirus (CMV) reactivation persists after kidney transplantation…2017 American Transplant Congress
Pre-Transplant CMV-Specific T-Cell Immunity Is an Additional Independent Variable Predicting CMV Infection After Kidney Transplantation.
Background: Current pre-transplant risk stratification for Cytomegalovirus (CMV) infection is based on donor/recipient (D/R) IgG-serostatus and clinical variables such as the use of T-cell depletion…2017 American Transplant Congress
BK Polyomavirus-Specific 9mer T-Cell Responses Predict Control of Viremia in Kidney Transplant Recipients: First Report from the Swiss Transplant Cohort Study.
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen KT patients for BKPyV viremia…2017 American Transplant Congress
FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-CMV IgG, Resulting in Inhibition of Antibody (Ab)-Mediated NK Cell Activation in Kidney Transplant Patients (KTX Pts).
Background: Viral infections represent significant morbidity factors for KTx Pts. Ab-dependent cell-mediated cytotoxicity (ADCC) is a major pathway to eliminate virally infected cells and is…
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