ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2018 American Transplant Congress

    Characterization of Mesenchymal Stem Cell Phenotype and Its Immunomodulatory Effects during Allo-Specific T Cell Immune-Responses

    Q. Gao, A. Kirk, H. Xu.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Mesenchymal stem cells (MSCs) have been suggested play an important role in modulating cell-mediated immunity. In the setting of transplantation, allogeneic MSCs could mediate suppressive…
  • 2018 American Transplant Congress

    Increased Expression of CEACAM1 is Cytoprotective during Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    R. Sosa,1 J. Nevarez-Mejia,1 M. Rossetti,1 A. Zarrinpar,2 F. Kaldas,2 C. Lassman,1 B. Naini,1 N. Datta,2 R. Busuttil,2 D. Gjertson,1 J. Kupiec-Weglinski,2 E. Reed.1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; 2Surgery, University of California, Los Angeles, Los Angeles, CA.

    Background T cell exhaustion has recently been proposed as an alternative mechanism to prevent memory development and tissue damage arising during ischemia-reperfusion injury (IRI) in…
  • 2018 American Transplant Congress

    CMV Viremia and Development of CMV-Specific Cytotoxic T-Cells (CMV-Tc) in Pediatric Renal Transplant Recipients

    H. Pizzo, B. Shin, M. Toyoda, S. Jordan, D. Puliyanda.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: The use of lymphocyte depleting agents (LDA) for induction immunosuppression among renal transplant (tx) recipients raises concern for the increased susceptibility to viral infections,…
  • 2018 American Transplant Congress

    CMV-Specific Cell-Mediated Immunity after Valgancyclovir Prophylaxis Predicts Late Onset CMV Infection in Kidney Transplant Patients

    M. Jarque,1 E. Crespo,1 E. Melilli,2 A. Manonelles,2 N. Montero,2 S. Luque,1 J. Cruzado,1,2 J. Grinyo,1,2 O. Bestard.1,2

    1Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.

    Background: There is currently no means to predict late-onset CMV infection after a long course of post-transplant Valgancyclovir prophylaxis therapy and its development still negatively…
  • 2018 American Transplant Congress

    Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients

    D. Kumar,1 P. Chin-Hong,2 L. Kayler,3 D. Wojciechowski,4 A. Limaye,5 O. Gaber,6 S. Ball,7 A. Mehta,8 T. Blanchard,9 C. Kotton.4

    1UHN, Toronto, Canada; 2UCSF, San Francisco; 3ECMC, Buffalo; 4MGH, Boston; 5UOWMC, Seattle; 6WCMC, Houston; 7UHB, Birmingham, United Kingdom; 8EmoryU, Atlanta; 9Oxford Diag, Marlborough.

    Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
  • 2018 American Transplant Congress

    Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant

    S. Ge,1 M. Chu,1 A. Karasyov,1 D. Lovato,1 J. Kahwaji,2 A. Vo,1 J. Choi,1 S. Louie,1 S. Jordan,1 M. Toyoda.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Kidney Transplantation, Kaiser Permanente Medical Center, Los Angeles, CA.

    Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…
  • 2018 American Transplant Congress

    Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients

    L. Higdon,1 J. Trofe-Clark,2 S. Liu,1 N. Saligrama,1 K. Margulies,2 M. Davis,1 J. Maltzman.1,3

    1Stanford U, Stanford, CA; 2U Pennsylvania, Philadelphia, PA; 3VA Palo Alto, Palo Alto, CA.

    Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…
  • 2018 American Transplant Congress

    C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms

    J. Horwitz, D. Mathern, P. Heeger.

    Icahn School of Medicine at Mount Sinai, NY, NY.

    The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…
  • 2018 American Transplant Congress

    Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance

    M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.

    Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.

    A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…
  • 2018 American Transplant Congress

    Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells

    R. Bascom, K. Tao, L. West.

    Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.

    Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
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