ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2019 American Transplant Congress

    The Impact of Biological Behavior of Allograft Infiltrating Lymphocytes during Early Phase

    Y. Ganchiku, R. Goto, R. Igarashi, R. Kanazawa, K. Shibuya, Y. Fukasaku, N. Kawamura, M. Zaistu, M. Watanabe, M. Fukai, A. Taketomi

    Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan

    *Purpose: The graft infiltrating lymphocytes (GILs) build an immunological microenvironment locally. Reportedly the GILs within 72hrs posttransplantation do not attack allograft, but may prevent from…
  • 2019 American Transplant Congress

    Race-Sex Effects on Immune Response Potential during Tacrolimus Minimization Therapy in Stable Renal Allograft Recipients

    K. Tornatore1, K. Attwood2, R. Venuto3, H. Minderman4

    1University at Buffalo; School of Pharmacy, Buffalo, NY, 2Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 3University at Buffalo; School of Medicine: Nephrology, Buffalo, NY, 4Flow & Image Cytometry, Roswell Park Comprehensive Cancer Center, Buffalo, NY

    *Purpose: African American renal transplant recipients (RTR) exhibit more immunoreactivity to allografts which may contribute to chronic rejection. This study investigated race-sex influences on ex…
  • 2019 American Transplant Congress

    Use of a CMV Specific T Cell Immunity Assay in Late-Onset CMV Infection

    O. Beaird1, M. Carlson1, P. Gaynor1, D. Nanayakkara1, B. Abdalla2, S. Bunnapradist2, J. Schaenman1

    1Department of Internal Medicine - Division Infectious Diseases, UCLA, Los Angeles, CA, 2Department of Internal Medicine - Division Nephrology, UCLA, Los Angeles, CA

    *Purpose: To describe our clinical experience using a CMV Specific Cell Mediated Immunity (CMI) assay in solid organ transplant (SOT) recipients with late-onset CMV, defined…
  • 2019 American Transplant Congress

    Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

    E. Crespo1, A. Vidal1, A. Sefrin2, P. Fontova1, M. Stein2, H. Volk2, J. Grinyó3, P. Reinke2, N. Lloberas1, O. Bestard3

    1Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, 3Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
  • 2019 American Transplant Congress

    Anti-ebv Antibody (ebv-ab) And Ebv-specific Cytotoxic T Cell (ebv-tc) Positivity Are Essential To Control Viremia In Seronegative (sero[-]) Pediatric Kidney Transplant Recipients (ped Ktx Pts).

    B. Shin, H. Pizzo, D. Puliyanda, A. Petrosyan, D. Lovato, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: EBV infection represents a significant morbidity factor in KTx Pts, especially EBV sero(-) Ped as infections tend to be more severe and recurrent, increasing…
  • 2019 American Transplant Congress

    Anti-cmv Antibody (cmv-ab) And Cmv-specific Cytotoxic T Cell (cmv-tc) Positivity Are Essential To Control Severe Viremia In Seronegative (sero[-]) Pediatric Kidney Transplant Recipients (ped Ktx Pts).

    B. Shin, H. Pizzo, D. Puliyanda, A. Petrosyan, D. Lovato, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: CMV infection represents a significant morbidity factor in KTx Pts, especially CMV sero(-) Ped Pts as infections tend to be more severe and recurrent.…
  • 2019 American Transplant Congress

    Evaluating Allo-Specific CD57+ T Cells during Memory and Proliferative Responses

    A. Lucander, H. Xu, A. Kirk

    Department of Surgery, Duke University, Durham, NC

    *Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…
  • 2019 American Transplant Congress

    High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity

    S. Moshkelgosha, S. C. Juvet

    UHN, Toronto, ON, Canada

    *Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…
  • 2018 American Transplant Congress

    CMV Viremia and Development of CMV-Specific Cytotoxic T-Cells (CMV-Tc) in Pediatric Renal Transplant Recipients

    H. Pizzo, B. Shin, M. Toyoda, S. Jordan, D. Puliyanda.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: The use of lymphocyte depleting agents (LDA) for induction immunosuppression among renal transplant (tx) recipients raises concern for the increased susceptibility to viral infections,…
  • 2018 American Transplant Congress

    CMV-Specific Cell-Mediated Immunity after Valgancyclovir Prophylaxis Predicts Late Onset CMV Infection in Kidney Transplant Patients

    M. Jarque,1 E. Crespo,1 E. Melilli,2 A. Manonelles,2 N. Montero,2 S. Luque,1 J. Cruzado,1,2 J. Grinyo,1,2 O. Bestard.1,2

    1Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.

    Background: There is currently no means to predict late-onset CMV infection after a long course of post-transplant Valgancyclovir prophylaxis therapy and its development still negatively…
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