ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell reactivity"

  • 2019 American Transplant Congress

    Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

    E. Crespo1, A. Vidal1, A. Sefrin2, P. Fontova1, M. Stein2, H. Volk2, J. Grinyó3, P. Reinke2, N. Lloberas1, O. Bestard3

    1Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, 3Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
  • 2019 American Transplant Congress

    Anti-ebv Antibody (ebv-ab) And Ebv-specific Cytotoxic T Cell (ebv-tc) Positivity Are Essential To Control Viremia In Seronegative (sero[-]) Pediatric Kidney Transplant Recipients (ped Ktx Pts).

    B. Shin, H. Pizzo, D. Puliyanda, A. Petrosyan, D. Lovato, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: EBV infection represents a significant morbidity factor in KTx Pts, especially EBV sero(-) Ped as infections tend to be more severe and recurrent, increasing…
  • 2019 American Transplant Congress

    Anti-cmv Antibody (cmv-ab) And Cmv-specific Cytotoxic T Cell (cmv-tc) Positivity Are Essential To Control Severe Viremia In Seronegative (sero[-]) Pediatric Kidney Transplant Recipients (ped Ktx Pts).

    B. Shin, H. Pizzo, D. Puliyanda, A. Petrosyan, D. Lovato, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: CMV infection represents a significant morbidity factor in KTx Pts, especially CMV sero(-) Ped Pts as infections tend to be more severe and recurrent.…
  • 2019 American Transplant Congress

    Evaluating Allo-Specific CD57+ T Cells during Memory and Proliferative Responses

    A. Lucander, H. Xu, A. Kirk

    Department of Surgery, Duke University, Durham, NC

    *Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…
  • 2019 American Transplant Congress

    High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity

    S. Moshkelgosha, S. C. Juvet

    UHN, Toronto, ON, Canada

    *Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…
  • 2019 American Transplant Congress

    Microparticle Delivery to Lymph Nodes Induces Specific Suppression to Prolong Islet Survival

    Y. Xiong1, L. Tostanoski2, C. Jewell3, J. Bromberg1

    1Surgery, U. Maryland, Baltimore, MD, 2U.Maryland, Baltimore, MD, 3U. Maryland, College Park, MD

    *Purpose: Microparticles (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either pro­inflammatory or anti­inflammatory…
  • 2019 American Transplant Congress

    Using a Commercially Available Assay That Measures Cytomegalovirus-Specific CD4+ and CD8+ T-cell Immunity to Predict Clinically Significant Cytomegalovirus Events in Solid Organ Transplant Recipients

    R. Rogers1, K. Saharia2, A. Chandorkar2, Z. Weiss3, D. Farmakiotis1

    1Infectious Diseases, Brown University, Providence, RI, 2Infectious Diseases, University of Maryland, Baltimore, MD, 3Internal Medicine, Brown University, Providence, RI

    *Purpose: To assess the diagnostic performance and clinical utility of the Viracor CMV T-cell Immunity Panel (CMV-TCIP), which measures both CMV-specific Cd4+ and Cd8+ T-cell…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2018 American Transplant Congress

    CMV-Specific Cell-Mediated Immunity after Valgancyclovir Prophylaxis Predicts Late Onset CMV Infection in Kidney Transplant Patients

    M. Jarque,1 E. Crespo,1 E. Melilli,2 A. Manonelles,2 N. Montero,2 S. Luque,1 J. Cruzado,1,2 J. Grinyo,1,2 O. Bestard.1,2

    1Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.

    Background: There is currently no means to predict late-onset CMV infection after a long course of post-transplant Valgancyclovir prophylaxis therapy and its development still negatively…
  • 2018 American Transplant Congress

    Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients

    D. Kumar,1 P. Chin-Hong,2 L. Kayler,3 D. Wojciechowski,4 A. Limaye,5 O. Gaber,6 S. Ball,7 A. Mehta,8 T. Blanchard,9 C. Kotton.4

    1UHN, Toronto, Canada; 2UCSF, San Francisco; 3ECMC, Buffalo; 4MGH, Boston; 5UOWMC, Seattle; 6WCMC, Houston; 7UHB, Birmingham, United Kingdom; 8EmoryU, Atlanta; 9Oxford Diag, Marlborough.

    Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
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