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Articles tagged "T cell reactivity"

  • 2022 American Transplant Congress

    Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies

    A. S. Kurt1, P. Ruiz1, E. Kodela1, G. Lombardi1, M. Martinez-Llordella2, A. Sanchez-Fueyo1

    1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom

    *Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…
  • 2021 American Transplant Congress

    Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome

    K. Janek1, J. H. Fechner1, R. A. Daley1, K. Krautkamer1, F. Rey2, J. D. Mezrich1

    1Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, 2Bacteriology, University of Wisconsin, Madison, WI

    *Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
  • 2021 American Transplant Congress

    Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells

    K. Lee, K. Deng, G. Huai, F. Qiang, C. Rickert, J. Lei, C. Leguern, J. Markmann

    Massachusetts General Hospital, Boston, MA

    *Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…
  • 2021 American Transplant Congress

    Naïve Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function

    M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab

    Department of Surgery, University of Pittsburgh, PITTSBURGH, PA

    *Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
  • 2021 American Transplant Congress

    K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells

    A. B. Morris, E. Peek, A. Hadley, C. P. Larsen

    Emory Transplant Center, Emory University, Atlanta, GA

    *Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…
  • 2021 American Transplant Congress

    The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection

    A. Mendoza Rojas1, T. van Gelder2, R. de Kuiper1, D. Reijerkerk1, M. C. Clahsen-van Groningen3, D. A. Hesselink1, C. C. Baan1, N. M. van Besouw1

    1Internal Medicine, Neprology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands, 2Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands, 3Internal Medicine, Pathology, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…
  • 2021 American Transplant Congress

    Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation

    K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan

    *Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
  • 2020 American Transplant Congress

    Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG

    K. Lee1, C. Rickert1, K. Deng1, N. Feeney1, N. Tanimine2, Q. Fu1, G. Huai1, J. Lei1, C. Leguern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
  • 2020 American Transplant Congress

    Evaluating Preformed Donor HLA Reactive T Cells Using PIRCHE-II Algorithm

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto1, A. Kanda1, K. Futamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi2, M. Niemann3, E. Spierings4

    1Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan, 2Kidney Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan, 3PIRCHE AG, Berlin, Germany, 4University Medical Center Utrecht, Utrecht, Netherlands

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) production involves the indirect allorecognition pathway in which recipient CD4+T cells recognize donor-HLA-derived peptide and recipient HLA class…
  • 2020 American Transplant Congress

    Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation

    J. Wu

    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
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