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Articles tagged "T cell reactivity"

  • 2022 American Transplant Congress

    Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection

    M. Cano1, D. Zhou2, C. Chen3, K. Pugh4, D. Byers1, D. Kreisel5, R. Hachem1, A. Gelman5

    1Pulmonary and Critical Care, Washington University, Saint Louis, MO, 2Surgery, Washington University, Saint Louis, MO, 3Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, 4Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 5Surgery and Immunology and Pathology, Washington University, Saint Louis, MO

    *Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
  • 2021 American Transplant Congress

    Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome

    K. Janek1, J. H. Fechner1, R. A. Daley1, K. Krautkamer1, F. Rey2, J. D. Mezrich1

    1Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, 2Bacteriology, University of Wisconsin, Madison, WI

    *Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
  • 2021 American Transplant Congress

    Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells

    K. Lee, K. Deng, G. Huai, F. Qiang, C. Rickert, J. Lei, C. Leguern, J. Markmann

    Massachusetts General Hospital, Boston, MA

    *Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…
  • 2021 American Transplant Congress

    Naïve Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function

    M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab

    Department of Surgery, University of Pittsburgh, PITTSBURGH, PA

    *Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
  • 2021 American Transplant Congress

    K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells

    A. B. Morris, E. Peek, A. Hadley, C. P. Larsen

    Emory Transplant Center, Emory University, Atlanta, GA

    *Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…
  • 2021 American Transplant Congress

    The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection

    A. Mendoza Rojas1, T. van Gelder2, R. de Kuiper1, D. Reijerkerk1, M. C. Clahsen-van Groningen3, D. A. Hesselink1, C. C. Baan1, N. M. van Besouw1

    1Internal Medicine, Neprology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands, 2Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands, 3Internal Medicine, Pathology, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…
  • 2021 American Transplant Congress

    Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation

    K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan

    *Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
  • 2020 American Transplant Congress

    Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation

    J. Wu

    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
  • 2020 American Transplant Congress

    Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial

    O. Bestard1, P. Reinke2, F. Bemelman3, O. Viklicky4, M. Koch5, M. Giral6, J. Ruiz7, B. Banas8, E. Crespo1, M. Meneghini1, H. Volk9, J. Grinyo1

    1Kidney transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Kidney transplantation Unit, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Kidney transplantation Unit, Amsterdam Medical Centre, Amsterdam, Netherlands, 4Nephrology department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, 5Department of Hepatobiliary Surgery and Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 6Nephrology, Kidney transplantation Unit, Université de Nantes, Nantes, France, 7Nephrology, Hospital Marques de Valdecilla, Santander, Spain, 8Kidney transplantation Unit, University Hospital Regensburg, Regensburg, Germany, 9Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…
  • 2020 American Transplant Congress

    Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion

    P. Cravedi, M. Fribourg, S. Harztell, L. Anderson, P. Heeger

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
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