2022 American Transplant Congress
Gm2a Regulates Memory Cd8+ T Cell Activation and Differentiation
*Purpose: In a clinical trial, patients who underwent kidney transplantation and were subsequently stable off tacrolimus immunosuppression exhibited increased Gm2a transcript in PBMC relative to…2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…2021 American Transplant Congress
Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells
Massachusetts General Hospital, Boston, MA
*Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…2021 American Transplant Congress
Naïve Rhesus Monkey CD4+CD8loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function
Department of Surgery, University of Pittsburgh, PITTSBURGH, PA
*Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…2021 American Transplant Congress
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…2021 American Transplant Congress
The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection
*Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…2021 American Transplant Congress
Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation
*Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…2020 American Transplant Congress
Novel Flow-Based Assay to Detect Allospecific T Cells in Transplantation Study
*Purpose: Identifying and phenotyping donor-reactive T cells in recipients following transplantation may further the understanding of interactions between the recipient’s immune system and donor antigen.…
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