2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
1Transplant Research Program, Boston Children's Hospital, Boston; 2MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…2016 American Transplant Congress
Acute Rejection in Non-Human Primates Treated with Belatacept Is Mediated by a Unique CD8 Memory Subset.
Belatacept is a high affinity version of the fusion protein CTLA4-Ig that blocks CD28 mediated T cell costimulation, providing a more targeted/less toxic form of…2015 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
BACKGROUND: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system. This makes it an attractive target for reducing chronic allograft…2015 American Transplant Congress
CD3+CD4+ROR gamma t+ TH17 Cells Do Not Play a Critical Role in Islet Allograft Rejection
Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA.
We have developed a “color-coded” adoptive transfer model for T cell subset identification that enables serial analysis of islet allograft infiltrating yellow induced regulatory T…2015 American Transplant Congress
Effector T Cell Migration to Pancreatic Islet Allografts Is Dependent On Donor Antigen Recognition and Not Gαi Chemokine Signaling
Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA.
Infiltration of the graft with host effector T cells after transplantation is a key step in the pathogenesis of both acute and chronic rejection. Recent…2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…2015 American Transplant Congress
Not Only CD28null But Also CD28pos T Cells Contribute to Rejection During Belatacept Treatment
To explain the underlying immunological mechanisms for rejection under belatacept treatment, the phenotypical and functional characteristics of graft infiltrating lymphocytes were studied during rejection under…2015 American Transplant Congress
Bidirectional Regulation and IL35 Surface Expression By Treg Cells
Surgery, University of Wisconsin, Madison, WI.
Background: Pre-transplant regulation on the donor side(toward the recipient), as well as the recipient side(toward the donor) promotes long-term graft survival of a kidney allo-graft…2015 American Transplant Congress
Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury
Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ischemia reperfusion injury of transplanted organs represents a key pathogenic inflammatory process, which increases their allogenicity; subsequently augmenting the rate of acute and chronic rejection.…2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…
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