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American Transplant Congress abstracts

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Articles tagged "T cell clones"

  • 2022 American Transplant Congress

    Autencoder, a Novel Computational Tool to Score T Cell Clones Demonstrates Biopsy T Cell Clones Are Not Represented in the Peripheral Blood

    N. Borcherding, A. Leckie-Harre, H. Wu, B. D. Humphreys, A. F. Malone

    Washington University, St Louis, MO

    *Purpose: Antibody-mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. The generation and…
  • 2022 American Transplant Congress

    The Impact of T-Cell Receptor Diversity in Acute Kidney Transplant Rejection

    T. Sigdel1, P. Fields2, J. Liberto1, I. Damm1, M. Kerwin1, j. Hood2, P. Towfighi1, M. Sirota1, H. Robins2, M. M. Sarwal1

    1UCSF, San Francisco, CA, 2Adaptive Biotechnologies, Seattle, WA

    *Purpose: Recent developments in T-cell receptor (TCR) immunosequencing allow for analysis of alloreactive human T-cell populations both before and after engraftment. In this study, we…
  • 2022 American Transplant Congress

    Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Novartis Pharmaceuticals AG, Basel, Switzerland, 4Internal Medicine, University of Cincinnati, Cincinnati, OH, 5Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…
  • 2021 American Transplant Congress

    Kidney Transplant Rejection Can Be Diagnosed or Even Predicted by Tracking Donor Reactive T Cell Clones in Post-transplant Samples

    Y. Sambandam1, M. Kandpal1, J. He1, X. Huang1, T. S. Taylor1, A. A. Shetty2, J. M. Mathew1, J. R. Leventhal1

    1Surgery-Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine, Nephrology Division, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: To test if kidney transplant (KTx) rejection can be diagnosed by monitoring for donor reactive T-cell (DRTC) clones in post-transplant (post-tx) biopsy and non-invasively…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring

    K. R. Sherwood1, P. Wong1, F. Fenninger1, V. Wu1, J. Beckrud2, D. P. Cina3, L. Allan2, J. Lan2, P. A. Keown2

    1University of British Columbia, Vancouver, BC, Canada, 2Vancouver General Hospital, Vancouver, BC, Canada, 3Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada

    *Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
  • 2020 American Transplant Congress

    Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation

    C. Aschauer1, K. Jelencsics1, K. Hu1, R. Reindl-Schwaighofer1, J. Vetter2, A. Heinzel1, A. Kainz1, G. Gualdoni1, S. Schaller2, S. Winkler2, R. Oberbauer1

    1Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, 2Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg im Muehlkreis, Austria

    *Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…
  • 2019 American Transplant Congress

    Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation

    J. Fu1, J. Zuber1, B. Shonts1, A. Obradovic1, K. Frangaj1, E. E. Waffarn1, S. Lau1, T. M. Savage1, S. Yang1, K. Rogers1, P. Satwani2, S. Ho1, Y. Shen3, A. Griesemer4, M. Martinez2, T. Kato4, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Systems Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…
  • 2019 American Transplant Congress

    T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection

    R. Reindl-Schwaighofer1, J. Vetter2, J. Weinberger3, S. Schaller2, A. Heinzel1, G. Gualdoni1, C. Aschauer1, K. Jelencsics1, K. Hu1, S. Winkler2, R. Oberbauer1

    1Nephrology, Medical University of Vienna, Vienna, Austria, 2University of Applied Sciences Upper Austria, Hagenberg, Austria, 3Austrian Red Cross, Vienna, Austria

    *Purpose: Tissue infiltration of T-cells is the hallmark of acute cellular graft rejection. Next generation sequencing of T-cell receptors enables in depth analysis of the…
  • 2019 American Transplant Congress

    Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy

    M. V. Habal1, A. Myung2, H. Yan2, S. Rao2, S. Lin2, S. See2, P. Roy2, R. Shihab2, C. Marboe3, S. Restaino1, A. Han2, M. Givertz4, J. C. Madsen5, L. Addonizio1, M. Farr1, E. Zorn2

    1Cardiology, Columbia University Medical Center, New York, NY, 2Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 3Pathology, Columbia University Medical Center, New York, NY, 4Cardiology, Brigham and Women's Hospital, Boston, MA, 5Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…
  • 2018 American Transplant Congress

    Single-Cell Analysis of Graft Infiltrating T-Cells in Cardiac Allograft Vasculopathy

    M. Habal, A. Myung, H. Yan, S. Rao, S. Lin, P. Colombo, C. Marboe, S. Restaino, A. Han, M. Farr, E. Zorn.

    Medicine, Columbia University Medical Center, New York, NY.

    Background: Cardiac allograft vasculopathy (CAV) remains a leading cause of death after heart transplant.T-cells are thought to play a central role, yet the mechanism by…
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