2016 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Immunity and Tolerance.
University of Maryland, Baltimore, MD.
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…2016 American Transplant Congress
Kidney Allotransplantation Induces the Differentiation of Antigen-Experienced CD8 T Cells with Enhanced Metabolic Profiles.
Background. Naïve and memory CD8 T cells have been shown to exhibit different metabolic profiles, especially upon antigen stimulation. However, it is unknown whether the…2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…2016 American Transplant Congress
Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Patients.
[Background] IT is an efficacious treatment for chronic intestinal failure. Recent advance of immunosuppressive regimens have decreased the rejection rate and improved patient survival. The…2016 American Transplant Congress
Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8+ T Cell Responses.
The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…2016 American Transplant Congress
Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.
Our recent studies have documented the presence of high numbers of recipient antigen presenting cells (APCs) displaying donor MHC molecules (cross-dressed) on their surface after…2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…2016 American Transplant Congress
The Increase of Serum MiR-142-3p Level in Acute Cardiac Rejection as a Reflection of Exosome-Mediated Genetic Exchange Between T Cells and Endothelial Cells.
1Cardiology, Lund University, Lund, Sweden; 2PROOF Center of Excellence, Vancouver, Canada.
IntroductionIn the recent years, microRNAs has emerged as the popular biomarker candidate in the field of solid organ transplantation due to their expression patterns reflect…2016 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy to Prevent T Cell Activation and Effector Functions.
1Cleveland Clinic, Cleveland; 2Aeromics LLC, Cleveland.
Aquaporin 4 (AQP4) belongs to the family of integral transmembrane proteins highly permeable to water. We have previously reported that blocking AQP4 with small molecule…2015 American Transplant Congress
Repurposing Jak/STAT Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore.
PURPOSE: Transplant tolerance induction through conventional costimulation blockade (CoB) remains an elusive goal. Recent evidence suggests that inflammatory cytokines contribute to the activation of alloreactive…
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