ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2016 American Transplant Congress

    Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.

    D. Mathern, P. Heeger.

    Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
  • 2016 American Transplant Congress

    Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.

    M. Lubetzky,1 P. O Broin,2 Y. Bao,1 E. Akalin.1

    1Transplantation, Albert Einstein College of Medicine, Bronx; 2School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.

    Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
  • 2016 American Transplant Congress

    Cytometric Deep Profiling of the CD8+ T-Cell Compartment in Transplant Patients with CMV Viremia.

    V. Ferreira, D. Kumar, S. Husain, M. Bhat, P. Ashton, A. Humar.

    UHN, Toronto, Canada.

    Background: Cytomegalovirus (CMV) infection is a common opportunistic viral infection in transplant patients. Patterns of viremia and relapse are influenced by the host immune response,…
  • 2016 American Transplant Congress

    CD57+ CD4 T Cells Persist in the Periphery Following Kidney Transplantation.

    J. Espinosa,1,2 L. Stempora,1 R. Townsend,3 A. Kirk.1

    1Duke University, Durham; 2Emory University, Atlanta; 3Bristol-Meyers Squibb, Princeton.

    Purpose: We have shown that CD57+PD1- CD4 T cells play a role in belatacept-resistant rejection, but their mechanism of action is incompletely defined. Potential mechanisms…
  • 2016 American Transplant Congress

    miR-21 in Chronic Allograft Vasculopathy.

    V. Usuelli,1 M. Ben Nasr,1,2 F. D'Addio,1,2 L. Kaifeng,2 L. Borgese,3 L. Potena,3 A. Solini,4 C. Rossi,4 A. Secchi,1 D. Corradi,5 N. Chau,6 P. Fiorina.1,2

    1Ospedale San Raffaele, Milano, Italy; 2Boston Children's Hospital, Boston; 3University of Bologna, Bologna, Italy; 4University of Pisa, Pisa, Italy; 5University of Parma, Parma, Italy; 6Regulus Therapeutics Inc, San Diego.

    Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…
  • 2016 American Transplant Congress

    IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.

    G. Tilly,1,2 M. Yap,1,2 M. Giral,1,2,3 C. Pecqueur,4 S. Brouard,1,3 N. Degauque.1,3

    1UMR1064, INSERM, Nantes, France; 2Université de Nantes, Nantes, France; 3ITUN, CHU de Nantes, Nantes, France; 4UMR892, INSERM, Nantes, France.

    Background & Study Aim. We recently showed that an accumulation of highly differentiated TEMRA CD8 T cells in kidney transplant recipients with a stable graft…
  • 2016 American Transplant Congress

    Belatacept Does Not Inhibit Plasmablast Formation Supported by Follicular T Helper Cells, but Favors the Development of Transitional Regulatory B Cells in Kidney Transplant Patients.

    G. de Graav, D. Hesselink, M. Dieterich, R. Kraaijeveld, W. Weimar, C. Baan.

    Internal Medicine, Section Transplantation and Nephrology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands.

    Since the costimulatory inhibitor belatacept effectively blocks T-B cell interaction in animal transplant models, we studied the functional follicular T helper cells (TFH)-B cell interaction…
  • 2016 American Transplant Congress

    Single Cell Profiling of Th9 Cells Allows Identification of Functionally Different Subsets.

    K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki.

    Institute of Medical Immunology, Charite University Medicine, Berlin, Germany.

    T helper type 9 (Th9) cells represent a distinct subset of CD4+ effector T cells that is characterized by high secretion of interleukin (IL)-9. Protective…
  • 2016 American Transplant Congress

    Lymph Node Stromal Laminins Differentially Regulate T Cell Immunity and Tolerance.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…
  • 2015 American Transplant Congress

    Negative Effects of Being Obese or Overweight on T Regulatory (Treg) Cell Suppressive Function in Patients Listed for Lung Transplantation (Tx)

    T. Akimova,1 J. Diamond,2 D. Wilkes,3 D. Lederer,4 J. Christie,2 W. Hancock.1

    1Path & Lab Med, CHOP & UPenn, Philadelphia; 2Pulm, Allergy & Crit Care Med, UPenn, Philadelphia; 3Med, Microbiol & Immunol, Indiana Uni Sch of Med & Thoracic Transplant Prog, Indianapolis; 4Medicine, Columbia Uni, New York.

    Aim: Obese and overweight patients may be prone to adverse outcomes following lung Tx. We sought to determine the relationship between body mass index (BMI)…
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