Articles tagged "T cell activation"

2016 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy to Prevent T Cell Activation and Effector Functions.
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Cleveland Clinic, Cleveland; ²Aeromics LLC, Cleveland.
Aquaporin 4 (AQP4) belongs to the family of integral transmembrane proteins highly permeable to water. We have previously reported that blocking AQP4 with small molecule…
2016 American Transplant Congress
Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.
N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.
Surgery, University of Maryland, Baltimore, MD.
Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
2016 American Transplant Congress
Blockade of the ASC Coreceptor Enhances Hematopoietic Stem Cell Engraftment.
R. Elahimehr, S. Kasimsetti, A. Shigeoka, D. McKay.
UCSD, San Diego.
Purpose: HSC engraftment is essential for successful bone marrow transplantation, and successful HSC engraftment allows for induction of tolerance to solid organ allografts. Engrafted HSCs…
2016 American Transplant Congress
Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.
J. Ruben,¹ G. Garcia-Romo,¹ E. Breman,¹ S. van der Kooij,¹ A. Redeker,² R. Arens,² C. van Kooten.¹
¹Nephrology, Leiden University Medical Centre, Leiden, Netherlands; ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
L. Wang,¹ A. Beeler,² S. Dahiya,¹ R. Han,¹ W. Hancock.¹
¹CHOP & UPenn, Philadelphia, PA; ²Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…
2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Boston.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…
2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
T. Thornley,¹ P. Kyriazis,¹ K. Agarwal,¹ Z. Fang,¹ L. Ma,¹ V. Chipashvili,¹ M. Koulmanda,^1,2 T. Strom.^1,2
¹Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…
2016 American Transplant Congress
A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.
F. D'Addio,^1,2 A. Vergani,³ L. Potena,⁴ A. Maestroni,² S. Tezza,¹ M. Ben Nasr,¹ V. Usuelli,² M. Sbolli,¹ L. Borgese,⁴ A. Iacovoni,⁵ D. Corradi,⁶ R. Abdi,⁷ A. Secchi,² R. Starling,⁸ M. Sayegh,^7,9 W. Harmon,¹ D. Briscoe,¹ P. Heeger,¹⁰ A. Chandraker,⁷ F. Grigioni,⁴ P. Fiorina.^1,2
¹Boston Children's Hospital, Boston, MA; ²Ospedale San Raffaele, Milan, Italy; ³Dompe Research, Milan, Italy; ⁴University of Bologna, Bologna, Italy; ⁵Ospedale Papa Giovanni XXIII, Bergamo, Italy; ⁶University of Parma, Parma, Italy; ⁷Brigham and Women's Hospital, Boston; ⁸Cleveland Clinic, Cleveland; ⁹American University of Beirut, Lebanon, Lebanon; ¹⁰Icahn School of Medicine at Mount Sinai, New York.
Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…
2016 American Transplant Congress
Designing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Longterm Heart Allograft Acceptance While Inducing Immune Cell Exhaustion, Treg Induction and Memory Cell Suppression.
E. Sula Karreci,¹ A. Mihali,¹ M. Uehara,¹ A. Kurdi,¹ L. Riella,¹ R. Abdi,¹ H. Fan,² P. Singh,² C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston, MA; ²Department of Microbiology and Immunology, Weill Cornell Medicine, New York City, NY.
The constitutive Proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. However, immunoproteasomes (IP or i-20S) are primarily expressed…