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Articles tagged "T cell activation"

  • 2016 American Transplant Congress

    A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.

    F. D'Addio,1,2 A. Vergani,3 L. Potena,4 A. Maestroni,2 S. Tezza,1 M. Ben Nasr,1 V. Usuelli,2 M. Sbolli,1 L. Borgese,4 A. Iacovoni,5 D. Corradi,6 R. Abdi,7 A. Secchi,2 R. Starling,8 M. Sayegh,7,9 W. Harmon,1 D. Briscoe,1 P. Heeger,10 A. Chandraker,7 F. Grigioni,4 P. Fiorina.1,2

    1Boston Children's Hospital, Boston, MA; 2Ospedale San Raffaele, Milan, Italy; 3Dompe Research, Milan, Italy; 4University of Bologna, Bologna, Italy; 5Ospedale Papa Giovanni XXIII, Bergamo, Italy; 6University of Parma, Parma, Italy; 7Brigham and Women's Hospital, Boston; 8Cleveland Clinic, Cleveland; 9American University of Beirut, Lebanon, Lebanon; 10Icahn School of Medicine at Mount Sinai, New York.

    Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…
  • 2016 American Transplant Congress

    Designing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Longterm Heart Allograft Acceptance While Inducing Immune Cell Exhaustion, Treg Induction and Memory Cell Suppression.

    E. Sula Karreci,1 A. Mihali,1 M. Uehara,1 A. Kurdi,1 L. Riella,1 R. Abdi,1 H. Fan,2 P. Singh,2 C. Nathan,2 G. Lin,2 J. Azzi.1

    1Transplantation Research Center, Harvard Medical School, Boston, MA; 2Department of Microbiology and Immunology, Weill Cornell Medicine, New York City, NY.

    The constitutive Proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. However, immunoproteasomes (IP or i-20S) are primarily expressed…
  • 2016 American Transplant Congress

    Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.

    D. Mathern, P. Heeger.

    Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
  • 2016 American Transplant Congress

    Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.

    M. Lubetzky,1 P. O Broin,2 Y. Bao,1 E. Akalin.1

    1Transplantation, Albert Einstein College of Medicine, Bronx; 2School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.

    Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
  • 2016 American Transplant Congress

    Cytometric Deep Profiling of the CD8+ T-Cell Compartment in Transplant Patients with CMV Viremia.

    V. Ferreira, D. Kumar, S. Husain, M. Bhat, P. Ashton, A. Humar.

    UHN, Toronto, Canada.

    Background: Cytomegalovirus (CMV) infection is a common opportunistic viral infection in transplant patients. Patterns of viremia and relapse are influenced by the host immune response,…
  • 2016 American Transplant Congress

    CD57+ CD4 T Cells Persist in the Periphery Following Kidney Transplantation.

    J. Espinosa,1,2 L. Stempora,1 R. Townsend,3 A. Kirk.1

    1Duke University, Durham; 2Emory University, Atlanta; 3Bristol-Meyers Squibb, Princeton.

    Purpose: We have shown that CD57+PD1- CD4 T cells play a role in belatacept-resistant rejection, but their mechanism of action is incompletely defined. Potential mechanisms…
  • 2016 American Transplant Congress

    miR-21 in Chronic Allograft Vasculopathy.

    V. Usuelli,1 M. Ben Nasr,1,2 F. D'Addio,1,2 L. Kaifeng,2 L. Borgese,3 L. Potena,3 A. Solini,4 C. Rossi,4 A. Secchi,1 D. Corradi,5 N. Chau,6 P. Fiorina.1,2

    1Ospedale San Raffaele, Milano, Italy; 2Boston Children's Hospital, Boston; 3University of Bologna, Bologna, Italy; 4University of Pisa, Pisa, Italy; 5University of Parma, Parma, Italy; 6Regulus Therapeutics Inc, San Diego.

    Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…
  • 2016 American Transplant Congress

    IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.

    G. Tilly,1,2 M. Yap,1,2 M. Giral,1,2,3 C. Pecqueur,4 S. Brouard,1,3 N. Degauque.1,3

    1UMR1064, INSERM, Nantes, France; 2Université de Nantes, Nantes, France; 3ITUN, CHU de Nantes, Nantes, France; 4UMR892, INSERM, Nantes, France.

    Background & Study Aim. We recently showed that an accumulation of highly differentiated TEMRA CD8 T cells in kidney transplant recipients with a stable graft…
  • 2016 American Transplant Congress

    Belatacept Does Not Inhibit Plasmablast Formation Supported by Follicular T Helper Cells, but Favors the Development of Transitional Regulatory B Cells in Kidney Transplant Patients.

    G. de Graav, D. Hesselink, M. Dieterich, R. Kraaijeveld, W. Weimar, C. Baan.

    Internal Medicine, Section Transplantation and Nephrology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands.

    Since the costimulatory inhibitor belatacept effectively blocks T-B cell interaction in animal transplant models, we studied the functional follicular T helper cells (TFH)-B cell interaction…
  • 2016 American Transplant Congress

    Single Cell Profiling of Th9 Cells Allows Identification of Functionally Different Subsets.

    K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki.

    Institute of Medical Immunology, Charite University Medicine, Berlin, Germany.

    T helper type 9 (Th9) cells represent a distinct subset of CD4+ effector T cells that is characterized by high secretion of interleukin (IL)-9. Protective…
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