Articles tagged "T cell activation"

2017 American Transplant Congress
Donor Leukocytes Are Eliminated by the Host's Immune System Shortly After Skin Transplantation in Mice.
J. Marino, B. Gonzalez-Nolasco, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
We have recently reported the lack of donor passenger leukocytes in the recipient's lymphoid organs of mice recipient of a skin allograft. On the other…
2017 American Transplant Congress
Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.
J. Espinosa,¹ J. Lockley,¹ F. Shaw,¹ R. Osborne,¹ M. Joshi,¹ T. Woody,¹ M. Ellis,¹ B. Hollister,¹ J. Cheeseman,¹ R. Townsend,² A. Kirk.¹
¹Duke University, Durham; ²Bristol-Meyers Squibb, Princeton
CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…
2017 American Transplant Congress
The Inhibitory Effect of Plasma on T Cell Activation: Possible Role of Plasma Exchange in Anti Rejection Therapy.
A. Assounga,^1,2 S. Omarjee.¹
¹Dept Nephrology, University of KwaZulu-Natal, Durban, South Africa; ²Inkosi Albert Luthuli Central Hospital, Durban, South Africa
Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented.Aim: To compare…
2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
Y. Lei,¹ L. Chen,¹ Y. Wang,¹ A. Chong,¹ Y. Belkaid,² M.-L. Alegre.¹
¹Departments of Medicine and Surgery, University of Chicago, Chicago, IL; ²Immunity at Barrier Sites Initiative, NIAID, NIH, Bethesda
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…
2017 American Transplant Congress
Effective Thrombolytic Therapy of Hepatic Artery Thrombosis After Liver Transplantation – A Single-Center Experience.
M. Chen,¹ X. Lin,² W. Ju,¹ D. Wang,¹ Y. Ma,¹ L. Wu,¹ X. He,¹ G. Chen.¹
¹Organ Transplant Center, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; ²Department of Thyroid and Breast Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
BACKGROUND: Hepatic artery thrombosis (HAT) is a common complication of liver transplantation which causes lots of graft loss. The anastomoses of hepatic artery requires delicate…
2017 American Transplant Congress
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model.
S. Kim, D. Mathews, L. Higginbotham, C. Breeden, C. Larsen, A. Adams.
Emory Transplant Center, Emory University, Atlanta, GA
Background: The clinical implementation of costimulation blockade (CoB) provides long-term benefit to transplant recipients, with the short-term drawback of increased acute rejection. Cellular therapies are…
2017 American Transplant Congress
Inhibition of Memory T Cell Alloresponses by TIM-1+ B Cells.
B. Gonzalez-Nolasco, H. Tector, J. Markmann, G. Benichou.
Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA
Background:Alloreactive memory T cells mediate accelerated rejection of allografts and prevent tolerance induction. While regulatory B cells (Bregs) can promote tolerance induction through suppression of…
2017 American Transplant Congress
IVIg+Rituximab Desensitization (DES) Combined with Alemtuzumab (ATZ) Induction Does Not Increase Risk for Viral Infections (VIs) and Associated Complications in HLA-Sensitized (HS) Kidney Transplant Patients (KTx Pts).
S. Ge, B.-H. Shin, J. Mirocha, D. Thomas, M. Chu, E. Rodriguez, C. Chao, A. Petrosyan, O. Galera, A. Vo, J. Choi, A. Peng, J. Kahwaji, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory, Biostatistics Core and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: VIs represent significant morbidity factors in KTx pts. DES followed by KTx with ATZ induction increased successful Tx rates in HS pts, but may…
2017 American Transplant Congress
Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.
T. Maehana, T. Tanaka, N. Masumori.
Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
2017 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Activation.
T. Simon, J. Bromberg.
University of Maryland, Baltimore
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…