2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…2017 American Transplant Congress
T Cell Responses to Viral Peptide Stimulation Predict Influenza Vaccine-Induced Seroconversion in Pediatric Solid Organ Transplant Recipients.
Introduction: Biomarkers predictive of vaccine response are needed to determine the optimal timing of immunization post-transplantation. We previously found that low T-cell ELISPOT responses to…2017 American Transplant Congress
Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).
RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…2017 American Transplant Congress
Blockade of Tim-3 and PD-1 Reverses Dysfunctions of Tumor Infiltrating Lymphocytes in HBV Related Hepatocellular Carcinoma.
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The immunosuppression of tumor infiltrating lymphocytes (TILs) is associated with rapid progress of hepatitis B virus related hepatocellular carcinoma (HBV-HCC). The inhibition molecules of T…2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…2017 American Transplant Congress
Contribution of γδ T-Cell Subsets and IL-17A Release to Ischemia Reperfusion Injury (IRI) and Kidney Allograft Rejection in Mice.
Ischemia reperfusion injury (IRI) contributes to acute allograft injury and to delayed graft function (DGF) which is a trigger for acute rejection after kidney transplantation…2017 American Transplant Congress
Evaluation of Function and TCR signaling Profile of CD57+ T Cells in Allo-Specific Immunity.
Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…2017 American Transplant Congress
Patients with Renal Failure Have a pERK-Dependent Defective TCR-Mediated Activation of CD4+ T Cells.
Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
Introduction Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T cell system. Mitogen-activated protein kinases (MAPKs) including extracellular…2017 American Transplant Congress
Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.
1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC
Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
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