Articles tagged "T cell activation"

2017 American Transplant Congress
Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.
J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…
2017 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism.
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…
2017 American Transplant Congress
Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.
G. Raimondi,¹ X. Calderon-Colon,² J. Budihardjo,¹ A. Mirdad,¹ M. Iglesias-Lozano,¹ J. Walch,¹ W. Lee,¹ G. Brandacher,¹ J. Patrone.²
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; ²Johns Hopkins Applied Physics Laboratory, Laurel
BackgroundComplications from long-term use of calcineurin inhibitors are a major concern for transplant patients. To develop CNI-free therapies, we investigated an innovative drug delivery method…
2017 American Transplant Congress
Host-Derived, Intragraft Dendritic Cells Are Extensively Cross-Dressed by Donor MHC.
A. Hughes, H. Dai, A. Williams, M. Oberbarnscheidt, A. Morelli, F. Lakkis.
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsbugh, PA
Host dendritic cells (DC) are the primary driver of transplant rejection in secondary lymphoid tissues where they activate alloreactive T cells. Directly alloreactive T cells…
2017 American Transplant Congress
A New and Potent Distal Enhancer of the IL2 Gene.
R. Thomas,¹ P. Mehra,¹ M. Johnson,² S. Grant,² A. Wells.¹
¹Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA; ²Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…
2017 American Transplant Congress
Reduction of Recipient Cell Cross-Dressing with Donor MHC Molecules Prolongs Allograft Survival in Mice.
J. Marino, H. Tector, B. Gonzalez-Nolasco, A. Lellouch, A. Harney, C. Cetrulo, Jr, J. Markmann, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Cross-dressing of recipient cells with allogeneic MHC molecules carried by donor exosomes occurs regularly after transplantation. However, it is still unknown whether this phenomenon plays…
2017 American Transplant Congress
Donor Leukocytes Are Eliminated by the Host's Immune System Shortly After Skin Transplantation in Mice.
J. Marino, B. Gonzalez-Nolasco, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
We have recently reported the lack of donor passenger leukocytes in the recipient's lymphoid organs of mice recipient of a skin allograft. On the other…
2017 American Transplant Congress
Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.
J. Espinosa,¹ J. Lockley,¹ F. Shaw,¹ R. Osborne,¹ M. Joshi,¹ T. Woody,¹ M. Ellis,¹ B. Hollister,¹ J. Cheeseman,¹ R. Townsend,² A. Kirk.¹
¹Duke University, Durham; ²Bristol-Meyers Squibb, Princeton
CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…
2017 American Transplant Congress
The Inhibitory Effect of Plasma on T Cell Activation: Possible Role of Plasma Exchange in Anti Rejection Therapy.
A. Assounga,^1,2 S. Omarjee.¹
¹Dept Nephrology, University of KwaZulu-Natal, Durban, South Africa; ²Inkosi Albert Luthuli Central Hospital, Durban, South Africa
Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented.Aim: To compare…
2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
Y. Lei,¹ L. Chen,¹ Y. Wang,¹ A. Chong,¹ Y. Belkaid,² M.-L. Alegre.¹
¹Departments of Medicine and Surgery, University of Chicago, Chicago, IL; ²Immunity at Barrier Sites Initiative, NIAID, NIH, Bethesda
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…