2018 American Transplant Congress
Targeting Histone Deacetylase in Renal Tubular Epithelial Cells Inhibits Amplification of TH1 Cell-Mediated Inflammation
Inje University, Busan, Korea.
Background: Objective: More studies are focusing on renal tubular epithelial cells (RTECs) as a new target to restore inflammatory environment as clarifying their immune regulatory…2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…2018 American Transplant Congress
Age-Specific Effects of Tacrolimus Are Associated to Specific Changes of T Cell Metabolism
Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston.
Background: Energy metabolism of immune cells has been identified as critical in driving alloimmunity. While metabolic capacities change with aging, aspects linking age, immunosuppression, and…2018 American Transplant Congress
In Vivo Imaging and Function of Renal Tertiary Lymphoid Organs
Starzl Transplantation Institute, Pittsburgh.
Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues in the setting of chronic inflammation such as organ transplantation. The function…2018 American Transplant Congress
TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration
Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…2018 American Transplant Congress
Hematopoietic Cell Kinase (Hck) Regulates Effector and Regulatory T Cell (Treg) Function
Background: We found that upregulation of Hck mRNA expression, an Src family tyrosine kinase, in surveillance graft biopsies of kidney transplant patients associates with an…2018 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…2018 American Transplant Congress
Central Role of Mef2 Transcription Factors in Regulation of Foxp3 Expression and Treg Function
1CHOP, Philadelphia; 2UPenn, Philadelphia.
Foxp3+ Tregs express 4 class IIa Hdac enzymes (Hdac4, 5, 7 & 9) with little or no catalytic activity and yet when deleted, at least…2018 American Transplant Congress
Shikonin Inhibits Th17 Development through Repressing STAT3 Activation
Background: Th17-mediated inflammatory responses are detrimental for allograft acceptance and long-term survival after transplantation. Shikonin is a naphthoquinone pigment isolated from a traditional medicinal herb…2018 American Transplant Congress
Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling
Department of Surgery, Duke University Medical Center, Durham, NC.
Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…
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