2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…2017 American Transplant Congress
The Impact of Tracheal Epithelial Cells Apoptosis on the Biological Behavior of Bone Marrow Mesenchymal Stem Cells (BMSCs) in OB.
Background: During the development of obliterative bronchiolitis (OB), extensive extracellular matrix is deposited in the lumen of the bronchioli, and the number of myofibroblasts increases.…2017 American Transplant Congress
The Role of Natural Killer Cells in Recognition and Killing of Stem Cells and Stem Cell-Derived Hepatoblasts.
Surgery, Stanford University School of Medicine, Stanford, CA
The generation of stem cell-derived hepatocytes holds promise as a cell-based treatment for liver disease. However, the immune response to stem cell-derived grafts is poorly…2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…2017 American Transplant Congress
Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.
Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…2017 American Transplant Congress
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model.
Emory Transplant Center, Emory University, Atlanta, GA
Background: The clinical implementation of costimulation blockade (CoB) provides long-term benefit to transplant recipients, with the short-term drawback of increased acute rejection. Cellular therapies are…2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…2017 American Transplant Congress
Optimization of Pancreatic Islet-Like Clusters from hiPSCs for Cell Therapy in Type 1 Diabetes.
Surgery, Beth Israel Deaconess Medical Center, Boston, MA
IntroductionTreatment for Type 1 Diabetes (T1D) includes pancreas or islets of Langerhans transplantation. Pancreatic beta-like cells from differentiated human induced pluripotent stem cells (hiPSCs) offer…2017 American Transplant Congress
Confirmation of the Safety of Cryopreserved Human Cord Blood Derived Di-Chimeric Cells in the NSG Mouse Model.
Orthopaedics, University of Illinois at Chicago, Chicago, IL
Background: Cell therapies are a promising approach for tolerance induction in Vascularized Composite Allotransplantation (VCA). Thus, we have developed a new supportive therapy of ex…
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