Articles tagged "Stem cells"

2018 American Transplant Congress
Durable Donor Hematopoetic Stem Cell (HSC) Chimerism is Associated with Protection from Native Renal Disease Recurrence in Recipients of Combined HSC/Kidney Transplants
J. Leventhal,¹ L. Gallon,¹ J. Mathew,¹ J. Miller,¹ D. Stare,¹ S. Ildstad.²
¹Northwestern U, Chicago; ²U Louisville, Louisville.
Recurrence of the original cause of ESRD has been observed in trials of tolerance induction for kidney transplantation (KTx) where donor HSC have been used…
2018 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model
B. Swearingen,^1,2 S. Graves,^2,3 R. Storb,^2,3 D. Mathes.^1,2
¹Surgery; Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; ²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ³Medicine, University of Washington Medical Center, Seattle, WA.
PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…
2018 American Transplant Congress
Characterization of Mesenchymal Stem Cell Phenotype and Its Immunomodulatory Effects during Allo-Specific T Cell Immune-Responses
Q. Gao, A. Kirk, H. Xu.
Department of Surgery, Duke University Medical Center, Durham, NC.
Mesenchymal stem cells (MSCs) have been suggested play an important role in modulating cell-mediated immunity. In the setting of transplantation, allogeneic MSCs could mediate suppressive…
2018 American Transplant Congress
Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy
M. Siemionow,¹ J. Cwykiel,¹ E. Marchese,¹ G. Rafidi,¹ K. Futoma,¹ A. Heydemann,² J. Garcia-Martinez,² E. Szilagyi.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago; ²Physiology and Biophysics, University of Illinois at Chicago, Chicago.
PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
2018 American Transplant Congress
Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells on Hepatocytes Proliferation after Small-for-Size Liver Transplantation via RHO/ROCK Pathway
L. Chen, J. Zheng, J. Cai, J. Yao, K. Zeng, Y. Zhang, Y. Yang.
Department of Liver Transplantation, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Exosomes from umbilical cords-derived mesenchymal stem cells (UC-MSCs-Ex) have been recognized as their ability to promote tissue regeneration in many animal models. However, the in…
2018 American Transplant Congress
Extracellular Vesicles Derived from Huc-MSCs Alleviate Rat Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Neutrophil Inflammatory Response
J. Yao,^1,2 J. Cai,^1,2 J. Zheng,^1,2 L. Chen,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Mesenchymal stem cells (MSCs) have been reported possessing therapeutic effects on immunoregulation, tissue repair and regeneration from bench to bedside. Extracellular vesicles (EVs) derived from…
2018 American Transplant Congress
Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial
Q. Sun,¹ F. Han,¹ M. Zhao,² R. Cao,³ D. Zhao,¹ Z. Huang,¹ L. Hong,¹ Y. Peng,¹ Q. Sun.¹
¹Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Zhujiang Hospital, Southern Medical University, Guangzhou, China; ³Second Affiliated Hospital, Guangzhou Traditional Chinese Medicine University, Guangzhou, China.
Background: Delayed graft function (DGF) and acute rejection lead to adverse effects on graft outcomes. Optimal induction intervention should include both renal structure injury repair…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
Human Pancreatic ECM Scaffolds for Islet Culture and Transplantation
D. Tremmel, S. Sackett, A. Feeney, R. Maguire, J. Odorico.
Univ of Wisconsin, Madison.
Extracellular matrix (ECM) plays an important role through structural and biochemical interaction with cells. Tissue-specific ECM, attained through decellularization (decel), has been proposed in many…
2018 American Transplant Congress
Clinical Application of Mesenchymal Stromal Cells with a Simplified Protocol for ABO Incompatible Liver Transplantation in Severe Hepatic Failure Patients
Y. Zhang,^1,2 J. Zheng,^1,2 J. Cai,^1,2 J. Zhang,^1,2 K. Zeng,^1,2 J. Yao,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Objective The purpose of this study was to test the safety and efficacy of mesenchymal stromal cells (MSCs) treatment with a simplified protocol for ABO…

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