ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2020 American Transplant Congress

    Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival

    A. J. Matar, B. P. Lovasik, S. C. Kim, C. A. Breeden, D. A. Faber, D. V. Mathews, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…
  • 2020 American Transplant Congress

    CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury

    M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA

    *Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…
  • 2020 American Transplant Congress

    Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis

    Y. Jia, M. Xu, T. Zhu

    Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
  • 2020 American Transplant Congress

    Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation

    K. Rozenberg1, S. Lohmann2, M. Pool3, M. Eijken4, U. Møldrup5, B. Møller6, J. Sierra-Parraga7, M. Hoogduijn7, L. Lo Faro1, C. Moers3, J. Hunter1, A. Keller2, H. Leuvenink3, C. Baan7, R. Ploeg1, B. Jespersen2

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, 4Department of Renal Medicine, Aarhus University, Aarhus, Denmark, 5Department of Urology, Aarhus University, Aarhus, Denmark, 6Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, 7Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
  • 2020 American Transplant Congress

    microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…
  • 2020 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding

    Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
  • 2019 American Transplant Congress

    Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney

    S. Noel1, J. T. Kurzhagen1, S. Lee1, M. Sadasivam2, A. R. Hamad2, P. M. Pierorazio3, H. Rabb1

    1Medicine, Johns Hopkins University, Baltimore, MD, 2Pathology, Johns Hopkins University, Baltimore, MD, 3Urology, Johns Hopkins University, Baltimore, MD

    *Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
  • 2019 American Transplant Congress

    RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression

    J. Fair1, N. Liu1, S. G. Widen2, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
  • 2019 American Transplant Congress

    Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation

    J. Fair1, M. M. Shoja1, N. Liu1, I. Patrikeev2, M. Motamedi2, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX

    *Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
  • 2019 American Transplant Congress

    An Open-Label Proof-of-Principle Phase 2A Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)

    A. Chruscinski1, H. Atkins2, A. Clement2, D. Grant1, C. Bredsen2, E. Renner1, J. Zhang1, M. Epstein1, L. Lilly1, N. Selzner1, O. Adeyi1, R. Smith1, S. Moshkelgosha1, A. Humar1, S. Juvet1, G. Levy1

    1Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, 2Ottawa Hospital Research Institute, Ottawa, ON, Canada

    *Purpose: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
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