2020 American Transplant Congress
Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…2020 American Transplant Congress
CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…2020 American Transplant Congress
Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis
*Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…2020 American Transplant Congress
Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation
*Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…2020 American Transplant Congress
microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3
*Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…2020 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
Clinical Investigation, Madigan Army Medical Center, Tacoma, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…2019 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2A Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
*Purpose: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
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