ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Skin transplantation"

  • 2016 American Transplant Congress

    Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.

    L. Margoles, S. Laurie, C. Coopersmith, M. Ford.

    Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.

    Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…
  • 2015 American Transplant Congress

    IL-2/IL-2 Ab Complex Leads to Long-Term Tolerance in a Treg Dependent DST Model of Skin Allograft Transplantation in Which DST and Timing of the Antibody Complex Are Crucial

    G. Zhang,1 Y. Wang,1 M. Hu,1 A. Sawyer,1 J. Zhou,1 S. Grey,2 S. Alexander.1

    1Children's Hospital at Westmead, Sydney, Australia; 2Garvan Institute, Sydney, Australia.

    Background: In vivo Treg expansion using IL2 complexed with anti-IL2 antibody has been demonstrated to be effective in the induction of long-term acceptance of islet…
  • 2015 American Transplant Congress

    Immunological Characterization of Full Facial Transplant Recipients

    T. Borges,1 J. Azzi,1 S. Tullius,1 A. Chandraker,1 B. Pomahac,2 N. Najafian,1 L. Riella.1

    1Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Plastic Surgery, Boston.

    Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…
  • 2015 American Transplant Congress

    Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival

    L. Wang, A. Samanta, J. Huang, T. Bhatti, Z. Wang, R. Han, L. Levin, M. Levine, W. Hancock.

    CHOP/UPenn, Philadelphia.

    Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…
  • 2015 American Transplant Congress

    Vascularised Composite Allografts and Intestinal Transplantation: Does the Skin Component Provide a Pre-Rejection Marker for the Visceral Organ?

    G. Vrakas, H. Giele, R. Arantes, S. Reddy, P. Friend, A. Vaidya.

    Oxford Transplant Centre, Oxford University Hospitals, Oxford, United Kingdom.

    Introduction: Can the skin component of a synchronously transplanted vascularised composite allograft (VCA) be used as a pre-rejection marker for the intestinal transplant (IT)?Methods: Recipients…
  • 2015 American Transplant Congress

    Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice

    N. Nayakawde, P. Patil, K. Methe, M. Olausson.

    Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
  • 2015 American Transplant Congress

    The Role of Skin-Specific Immunobiology and Major Histocompatibility Complex Sharing in Vascularized Composite Allograft Tolerance

    D. Leonard, K. Shanmugarajah, H. Powell, A. Albritton, C. Mallard, D. Sachs, C. Cetrulo, Jr., J. Kurtz.

    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.

    Background: We have developed a reproducible model for induction of tolerance of all components of VCAs across haploidentical MHC barriers in miniature swine. The purpose…
  • 2015 American Transplant Congress

    Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts

    M. Madariaga, K. Shanmugarajah, S. Michel, V. Villani, G. La Muraglia II, R. Torabi, D. Leonard, M. Randolph, R. Colvin, K. Yamada, J. Madsen, C. Cetrulo, Jr., D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…
  • 2015 American Transplant Congress

    A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation

    A. Yang, Z. Guo, W. Ju, Y. Ma, A. Hu, Y. Chen, M. Chen, C. Wu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims:Our study was to build up a mouse model of pneumonitis induced by candida albicans infection after allogeneic skin transplantation.Methods:We used 10 male C57BL/6J mice…
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