2021 American Transplant Congress
Transforming Growth Factor-Beta Induced Myeloid-Derived Suppressor Cells Promote Transplant Immune Tolerance
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from bone marrow with immunosuppressive effect, which contribute to the establishment of transplant…2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…2020 American Transplant Congress
TGF-b Induced Myeloid-Derived Suppressor Cells Prevent Transplatation Rejection by Promoting Immune Tolerance
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a class of heterogeneous myeloid cells with immunosuppressive function. An effective method to produce MDSCs with better capacity and…2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…2020 American Transplant Congress
Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts
*Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…2019 American Transplant Congress
Facial Composite Tissue Allotransplantation: First Canadian Experience
1Hopital Maisonneuve-Rosemont, Montreal, QC, Canada, 2University of Montreal, Montreal, QC, Canada
*Purpose: Facial vascularized composite allotransplantation (VCA) has emerged as a groundbreaking reconstructive solution for patients with severely disfiguring facial injuries. It allows simultaneous “like with…2019 American Transplant Congress
Renal Failure as a Complication of Vascularized Composite Allotransplantation
*Purpose: Vascularized composite allotransplantation (VCA) has demonstrated impressive outcomes in areas of extremity (UETx), face (FTx), genitourinary, and abdominal wall transplantation with up to twenty…
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