Articles tagged "Skin transplantation"

2021 American Transplant Congress
Donor-specific Regulatory B Cells Prolong Skin Graft Survival by Preventing the Proliferation of Donor-specific CD4 Helper but Not of CD8 Effector T Cells
G. Huai¹, K. Lee², K. Deng², Q. Fu¹, C. G. Rickert², S. Deng¹, C. LeGuern², J. F. Markmann²
¹Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: TLR-Bregs were defined by our group as B cells generated in vitro. They have demonstrated the ability to inhibit CD4 T cell proliferation. Since…
2020 American Transplant Congress
Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts
M. Sepulveda¹, L. Chen¹, Y. Wang¹, J. Park¹, Z. Early¹, B. Jabri², A. Chong³, M. Alegre¹
¹Medicine, University of Chicago, Chicago, IL, ²Pathology, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…
2020 American Transplant Congress
Th17 Cell Inhibition in a Costimulation Blockade Based Regimen for Vascularized Composite Allotransplantation Using A Non-Human Primate Model
D. P. Moris, A. Atia, M. Rae, M. Song, L. Stempora, F. Leopardi, K. Williams, J. Kwun, W. Parker, A. Cardones, A. D. Kirk, L. C. Cendales
Surgery, Duke, Durham, NC
*Purpose: Vascularized composite allotransplantation (VCA) is challenged by the morbidity of non-specific immunosuppression required to prevent rejection. The use of highly specific biologics has not…
2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Adams
Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
X. Li¹, J. Zhao¹, L. Jiang¹, M. Uehara¹, V. Kasinath¹, S. Shin¹, S. G. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…
2020 American Transplant Congress
TGF-b Induced Myeloid-Derived Suppressor Cells Prevent Transplatation Rejection by Promoting Immune Tolerance
P. Cao, Z. Sun, J. Zhang, F. Zhang, W. Wang
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a class of heterogeneous myeloid cells with immunosuppressive function. An effective method to produce MDSCs with better capacity and…
2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
M. Mammadli¹, M. Karimi¹, S. Mahmudlu¹, A. August², W. Huang²
¹Microbiology and Immunology, Upstate Medical University, Syracuse, NY, ²Microbiology and Immunology, Cornell University, Ithaca, NY
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…
2019 American Transplant Congress
Renal Failure as a Complication of Vascularized Composite Allotransplantation
R. N. Barth¹, J. T. Shores², G. Brandacher², M. H. Levine³, A. Weissenbacher⁴, A. J. Nam¹, N. Shockcor¹, E. D. Rodriguez⁵, S. Schneeberger⁴, W. Lee², S. T. Bartlett¹, L. Levin³
¹University of Maryland School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Pennsylvania School of Medicine, Philadelphia, PA, ⁴Medical University Innsbruck, Innsbruck, Austria, ⁵New York University School of Medicine, New York, NY
*Purpose: Vascularized composite allotransplantation (VCA) has demonstrated impressive outcomes in areas of extremity (UETx), face (FTx), genitourinary, and abdominal wall transplantation with up to twenty…
2019 American Transplant Congress
Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses
J. Domen, Y. Li
Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO
*Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…