ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Skin transplantation"

  • 2022 American Transplant Congress

    Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?

    S. Jacob1, M. L. Baack2, A. Savinov3, P. J. Wettstein4

    1Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, 2Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, 3Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, 4Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
  • 2022 American Transplant Congress

    Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival

    R. Steiner1, A. M. Weijler1, M. Muckenhuber2, J. Sprent3, T. Wekerle4, N. Pilat1

    1Medical University of Vienna, Vienna, Austria, 2Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, 3Garvan Institute of Medical Research, Sydney, Australia, 4Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria

    *Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
  • 2022 American Transplant Congress

    Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model

    A. Han1, C. Chung2, H. Kim3, H. Ko4, E. Jo1, S. Min1, S. Kim5, H. Park5, J. Ha1

    1Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Inha University Hospital, Incheon, Korea, Republic of, 3Korea University Guro Hospital, Seoul, Korea, Republic of, 4Kyung Hee University Hospital, Seoul, Korea, Republic of, 5Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea, Republic of

    *Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…
  • 2022 American Transplant Congress

    P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation

    H. H. Lancia1, N. Carnel2, A. G. Lellouch1, C. Cetrulo1, G. Benichou2

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
  • 2022 American Transplant Congress

    TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3+ Treg

    C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford

    Emory University Transplant Center, Emory University, Atlanta, GA

    *Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
  • 2022 American Transplant Congress

    Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor

    E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer

    Columbia University Irving Medical Center, New York, NY

    *Purpose: The purpose of this study was to investigate whether expression of a humanized IL-3 receptor (hCD123+hCD131) transgene in a GalTKO pig would improve levels…
  • 2021 American Transplant Congress

    The Role of Notch2 in Antibody-mediated Alloimmune Response

    R. Benedetti Gassen1, N. Murakami2, T. J Borges1, A. Al Jurdi1, A. Alessandrini1, L. V Riella1

    1Center of Transplantation Science, Massachusetts General Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody mediated rejection is the leading cause of chronic allograft rejection. Developing a novel therapeutic target to inhibit chronic rejection is an urgent need…
  • 2021 American Transplant Congress

    Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates

    T. Hirose, D. Ma, G. Lassiter, T. Kawai

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
  • 2021 American Transplant Congress

    Gm2a: A Novel Regulatory Pathway Controlling Alloimmunity

    K. M. Baecher1, P. S. Heeger2, P. Cravedi2, M. Fribourg2, M. L. Ford1

    1Department of Surgery, Emory University, Atlanta, GA, 2Mount Sinai School of Medicine, New York, NY

    *Purpose: In recently published studies we discovered that the inhibitory receptor FcγRIIB regulates CD8+ T cell alloimmunity in a cell-autonomous fashion, and that increased expression…
  • 2021 American Transplant Congress

    Donor-specific Regulatory B Cells Prolong Skin Graft Survival by Preventing the Proliferation of Donor-specific CD4 Helper but Not of CD8 Effector T Cells

    G. Huai1, K. Lee2, K. Deng2, Q. Fu1, C. G. Rickert2, S. Deng1, C. LeGuern2, J. F. Markmann2

    1Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    *Purpose: TLR-Bregs were defined by our group as B cells generated in vitro. They have demonstrated the ability to inhibit CD4 T cell proliferation. Since…
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