Articles tagged "Skin transplantation"

2022 American Transplant Congress
Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?
S. Jacob¹, M. L. Baack², A. Savinov³, P. J. Wettstein⁴
¹Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, ²Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, ³Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, ⁴Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
R. Steiner¹, A. M. Weijler¹, M. Muckenhuber², J. Sprent³, T. Wekerle⁴, N. Pilat¹
¹Medical University of Vienna, Vienna, Austria, ²Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, ³Garvan Institute of Medical Research, Sydney, Australia, ⁴Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
2022 American Transplant Congress
Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model
A. Han¹, C. Chung², H. Kim³, H. Ko⁴, E. Jo¹, S. Min¹, S. Kim⁵, H. Park⁵, J. Ha¹
¹Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Inha University Hospital, Incheon, Korea, Republic of, ³Korea University Guro Hospital, Seoul, Korea, Republic of, ⁴Kyung Hee University Hospital, Seoul, Korea, Republic of, ⁵Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea, Republic of
*Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…
2022 American Transplant Congress
P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation
H. H. Lancia¹, N. Carnel², A. G. Lellouch¹, C. Cetrulo¹, G. Benichou²
¹Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
2022 American Transplant Congress
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3⁺ Treg
C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…
2022 American Transplant Congress
Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor
E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer
Columbia University Irving Medical Center, New York, NY
*Purpose: The purpose of this study was to investigate whether expression of a humanized IL-3 receptor (hCD123+hCD131) transgene in a GalTKO pig would improve levels…
2021 American Transplant Congress
The Role of Notch2 in Antibody-mediated Alloimmune Response
R. Benedetti Gassen¹, N. Murakami², T. J Borges¹, A. Al Jurdi¹, A. Alessandrini¹, L. V Riella¹
¹Center of Transplantation Science, Massachusetts General Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody mediated rejection is the leading cause of chronic allograft rejection. Developing a novel therapeutic target to inhibit chronic rejection is an urgent need…
2021 American Transplant Congress
Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates
T. Hirose, D. Ma, G. Lassiter, T. Kawai
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
2021 American Transplant Congress
Gm2a: A Novel Regulatory Pathway Controlling Alloimmunity
K. M. Baecher¹, P. S. Heeger², P. Cravedi², M. Fribourg², M. L. Ford¹
¹Department of Surgery, Emory University, Atlanta, GA, ²Mount Sinai School of Medicine, New York, NY
*Purpose: In recently published studies we discovered that the inhibitory receptor FcγRIIB regulates CD8+ T cell alloimmunity in a cell-autonomous fashion, and that increased expression…
2021 American Transplant Congress
Donor-specific Regulatory B Cells Prolong Skin Graft Survival by Preventing the Proliferation of Donor-specific CD4 Helper but Not of CD8 Effector T Cells
G. Huai¹, K. Lee², K. Deng², Q. Fu¹, C. G. Rickert², S. Deng¹, C. LeGuern², J. F. Markmann²
¹Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: TLR-Bregs were defined by our group as B cells generated in vitro. They have demonstrated the ability to inhibit CD4 T cell proliferation. Since…

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