ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sirolimus (SLR)"

  • 2021 American Transplant Congress

    Hospitalization in the First Year After Kidney Transplantation: Analyses to Identify Common Predictors of Risk Across Recipient Sensitization Groups

    A. Santos, E. Bueno, M. A. Leghrouz

    University of Florida, Gainesville, FL

    *Purpose: We investigated the risk of hospitalization associated with baseline risk factors in adult deceased donor (DD) kidney transplant (KT) recipients (KTRs) stratified into calculated…
  • 2020 American Transplant Congress

    Sirolimus Combined with Low-Dose Calcineurin Inhibitor in Kidney Transplant Recipients from Expanded Criteria Donors

    J. Zhang, J. Lin, Y. Tian, W. Sun, L. Zhang

    Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: To evaluate the efficacy and safety of conversion from calcineurin inhibitor-based immunosuppressive regimen to sirolimus combined with low-dose calcineurin inhibitor in recipients with abnormal…
  • 2020 American Transplant Congress

    The Impact of Sirolimus on Weight Gain Post Heart Transplant

    S. M. Gore, C. E. Raphael, K. Mara, C. Arendt, A. L. Clavell, S. A. Bernard

    Mayo Clinic, Rochester, MN

    *Purpose: Obesity is common after heart transplant (HT), resulting in increased risk of new onset diabetes, all-cause and cardiovascular mortality and graft failure. Immunosuppressants (ISN)…
  • 2020 American Transplant Congress

    Long Term Effect of Tacrolimus Conversion to Sirolimus with Prednisone-Free Regimen in Kidney Allograft Outcomes: A Dynamic Analysis of Graft Survival Using Joint Modeling

    S. H. Park1, B. Ho1, K. Guo1, L. Zhao2, V. Mas3, J. Leventhal4, L. Gallon1

    1Transplant Nephrology, Northwestern University, Chicago, IL, 2Preventive Medicine, Northwestern University, Chicago, IL, 3University of Tennesse, Memphis, TN, 4Transplant Surgery, Northwestern University, Chicago, IL

    *Purpose: Findings on long-term impacts of the mammalian target of rapamycin inhibitor inhibitors on kidney allograft are scarce and mixed. A joint modeling approach can…
  • 2020 American Transplant Congress

    Conversion to Sirolimus to Prevent Recurrent Cytomegalovirus Infection/Disease: A Prospective and Randomized Trial

    L. Almeida Viana, M. Pontello Cristelli, G. Basso, D. Wagner Castro Lima Santos, M. Taver Costa Dantas, Y. Cardoso Dreige, L. Damasceno, M. Rika Nakamura, H. Tedesco-Silva, J. Medina-Pestana

    Hospital do Rim - UNIFESP, São Paulo, Brazil

    *Purpose: Recurrent cytomegalovirus (CMV) infection occurs in 30-35% of kidney transplant recipients after completion of treatment and/or preemptive therapy. There is no consensus on the…
  • 2020 American Transplant Congress

    Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells

    S. Li, A. Kirk, H. Xu

    Surgery, Duke University, Durham, NC

    *Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…
  • 2019 American Transplant Congress

    Decreased Cancer Susceptibility in Tolerant Liver Transplant Recipients: Another Benefit of Tolerance?

    M. P. Bhat1, E. Pasini1, C. Baciu1, S. M. Kurian2, J. Levitsky3

    1Multi-Organ Transplant, UHN, Toronto, ON, Canada, 2Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 3Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Long-term survival of transplant recipients is significantly impacted by malignancy. Induction of tolerance is feasible in a subset of liver transplant (LT) recipients. The…
  • 2019 American Transplant Congress

    A Clinical Pharmacogenetic Model to Predict the Efficacy of Sirolimus during the Early Administration in Renal Transplant Recipients

    Z. Wang, S. Fei, Z. Han, J. Tao, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: This study was to develop a clinical pharmacogenetic model to predict the efficacy of sirolimus during the early administration in renal transplant recipients. 70…
  • 2019 American Transplant Congress

    Sirolimus (SRL) versus Everolimus (EVR) versus Mycophenolate (MPA) in Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction (r-ATG), Tacrolimus (TAC), and Prednisone

    C. Rosso Felipe, L. Viana, M. Pontello Cristelli, J. Toniato, K. Ficher, S. Poletto, H. Proença, R. de Marco, M. Gerbase-Lima, A. Brigido, J. Medina Pestana, H. Tedesco-Silva

    Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil

    *Purpose: TAC and MPA combination is considered the standard of care immunosuppressive regimen in the majority of transplant centers worldwide. Yet, given the lack of…
  • 2019 American Transplant Congress

    Comparison of Initial Sirolimus (SRL) and Everolimus (EVR) Exposure Patterns in Kidney Transplant Recipients

    C. Rosso Felipe, L. Viana, M. Pontello Cristelli, M. Nakamura, L. Ramagnoli, S. Braga, V. Lima, A. Carnevalle, D. Casarini, J. Medina Pestana, H. Tedesco Silva Junior

    Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil

    *Purpose: Despite distinct pharmacokinetic properties, SRL and EVR bind to the same intracellular target protein, suggesting that equivalent blood concentrations may exert similar pharmacodynamic effect.*Methods:…
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