Articles tagged "Sensitization"

2020 American Transplant Congress
Sensitization via Pregnancy Generates Alloantibody and Cross-Reactive Xeno-Antibody in a Non-Human Primate Model
J. Yoon, M. Manook, Z. Fitch, R. Schmitz, A. Choi, A. M. Jackson, S. Knechtle, J. Kwun
Surgery, Duke University, Durham, NC
*Purpose: Women are disproportionately represented among highly sensitized waitlist candidates and within HLA-incompatible transplantation programs. Due to difficulties obtaining compatible donors, sensitized patients are seen…
2020 American Transplant Congress
Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. P. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Follow Up of Imlifidase (IdeS) Desensitized Kidney Transplant Recipients
S. C. Jordan¹, R. A. Montgomery², T. Lundgren³, C. Legendre⁴, N. Desai⁵, G. Eckerwall⁶, L. Laxmyr⁶, H. Olsson⁶, A. Runström⁶, Å. Schiött⁶, K. Sjöholm⁶, E. Sonesson⁶, L. Winstedt⁶, T. Lorant⁷, C. Kjellman⁶
¹Cedars Sinai Medical Center, Los Angeles, CA, ²NYU Langone Health Transplant Institute, New York, NY, ³Karolinska University Hospital, Stockholm, Sweden, ⁴Hospital Necker & Paris Descartes University, Paris, France, ⁵Johns Hopkins University, Baltimore, MD, ⁶Hansa Biopharma AB, Lund, Sweden, ⁷Uppsala University, Uppsala, Sweden
*Purpose: 46 highly sensitized patients received kidney transplants after desensitization with imlifidase (currently under investigation) across four Phase 2 clinical trials, and 6-month safety and…
2020 American Transplant Congress
Kidney Paired Donation Outcomes among High PRA Recipients
A. Thomas¹, A. Shaffer², M. Henderson², D. Segev²
¹University of North Carolina, Chapel Hill, NC, ²Johns Hopkins, Baltimore, MD
*Purpose: Kidney paired donation (KPD) accounts for an increasing amount of living donor transplants in the US. Previous studies have shown equivalent outcomes between transplants…
2020 American Transplant Congress
When CPRA Zero is Not the Hero: Does KAS Disadvantage Unsensitized Relisted Patients?
M. Casey, Z. Su, M. Mohamed Ahmed, D. Taber, E. Weeda, T. Morinelli, P. Mauldin, K. Soliman, M. A. Posadas-Salas, V. Rao, D. DuBay
Medical University of South Carolina, Charleston, SC
*Purpose: Since the 2014 Kidney Allocation System (KAS) changes, patients with a very high calculated panel reactive antibody (CPRA) have received greater priority in deceased…
2020 American Transplant Congress
Possible Mechanism of Sensitization against Angiotensin Type II Receptor after LVAD Implantation
P. Kimball¹, V. Chau², F. McDougan¹, M. Flattery², K. Shah²
¹Surgery, VCUHS, Richmond, VA, ²Cardiology, VCUHS, Richmond, VA
*Purpose: Detection of antibody (Ab) against angiotensin-II receptor (AT1R) following VAD implantation portends poorer outcomes for heart transplantation (HT). However, the cause of this sensitization…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2020 American Transplant Congress
A Single Centre Report of Renal Transplantation Against a Positive Crossmatch Due to HLA-DP Donor Specific Antibodies without Prior Antibody Removal
Y. Marie¹, T. Key², A. Halawa¹
¹Renal Transplantation, Sheffield Kidney Institute, Sheffield, United Kingdom, ²2.Department of Histocompatibility and Immunogenetics, Sheffield, United Kingdom
*Purpose: In renal transplantation, the clinical effects of donor specific antibodies (DSA) against HLA-DP are unclear. We report successful kidney transplants in three highly sensitised…
2020 American Transplant Congress
Successful Liver-Kidney Transplantation in a Highly Sensitized Pediatric Patient
M. Bock, M. Chandran, J. Goebel, E. Blanchette, M. Wachs, M. Adams, S. Sundaram
Children's Hospital Colorado, Denver, CO
*Purpose: While immunologically challenging and controversial, we report a successful case of same donor staged simultaneous liver-kidney transplant (SLK) in a highly sensitized child against…
2019 American Transplant Congress
Single Center Deceased Donor Renal Transplant (DDRTx) Outcomes in Sensitized Patients after Implementation of the Kidney Allocation System (KAS)
S. S. Patel, K. L. King, J. Kamal, E. Vasilescu, A. Husain, S. Mohan, L. E. Ratner, R. Crew
Columbia University Irving Medical Center, New York, NY
*Purpose: Introduction of KAS in 2014 prioritized access to DDRTx for highly-sensitized candidates although it was unclear whether the outcomes would be acceptable in this…

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