Articles tagged "Sensitization"

2020 American Transplant Congress
Successful Liver-Kidney Transplantation in a Highly Sensitized Pediatric Patient
M. Bock, M. Chandran, J. Goebel, E. Blanchette, M. Wachs, M. Adams, S. Sundaram
Children's Hospital Colorado, Denver, CO
*Purpose: While immunologically challenging and controversial, we report a successful case of same donor staged simultaneous liver-kidney transplant (SLK) in a highly sensitized child against…
2020 American Transplant Congress
High Intra-Patient Variability of Tacrolimus in Pediatric and Adolescent Renal Transplant Recipients is Associated with Worse Graft Outcomes
K. Piburn¹, L. Maestretti², R. Shetty², M. V. Patton², A. McGrath², W. Concepcion¹, A. Chaudhuri¹, P. C. Grimm¹, V. K. Sigurjonsdottir³
¹Stanford University, Palo Alto, CA, ²Lucile Packard Children's Hospital Stanford, Palo Alto, CA, ³Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
*Purpose: High intra-patient variability (IPV) in tacrolimus (TAC) levels is associated with de novo donor-specific antibodies (dnDSA) and graft loss. We examined the natural history…
2020 American Transplant Congress
Outcomes of a Pre-Transplant Desensitization Protocol with Carfilzomib, Plasmapheresis, and IVIG for Broadly Sensitized Lung Transplant Candidates: A Case Series
S. Fredrick¹, C. Iasella², C. Moore¹, M. Mangiola³, Q. Xu³, C. Ensor⁴, D. Riciutti², C. LaFratte², P. Sanchez³, M. Morrell³, J. McDyer³, A. Zeevi³
¹Department of Pharmacy, UPMC Presbyterian, Pittsburgh, PA, ²University of Pittsburgh School of Pharmacy, Pittsburgh, PA, ³University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pharmacy, AdventHealth, Orlando, FL
*Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies in lung transplant candidates leads to increased wait list times and antibody-mediated rejection (AMR) post-transplant. We…
2020 American Transplant Congress
Three-Year Post-Transplant Outcome of Desensitized Mechanical Circulatory Support Patients Awaiting Heart Transplantation
J. Youn¹, R. Cole², D. Ramzy², E. Kim¹, J. Kobashigawa², J. Moriguchi²
¹Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Cedars-Sinai Heart Institute, Los Angeles, CA
*Purpose: Up to 30% of durable mechanical circulatory support (MCS) patients (pts) develop panel reactive antibody (PRA) screen >= 10%. In our program, desensitization (DS)…
2020 American Transplant Congress
Outcomes of CPRA 100% Deceased Donor Kidney Transplant Recipients Under the New Kidney Allocation System: A Single-Center Cohort Study
K. R. Jackson, J. Chen, E. Kraus, N. Desai, D. Segev, N. Alachkar
Johns Hopkins Hospital, Baltimore, MD
*Purpose: In light of changes in donor/recipient case-mix and increased cold ischemia times under KAS, there is some concern that cPRA 100% recipients might be…
2020 American Transplant Congress
Virtual XM Adversely Affects Access for Highly Sensitized African Americans Awaiting Renal Transplantation
P. T. Jindra¹, B. V. Murthy¹, C. Van Buren²
¹Surgery, Baylor College of Medicine, Houston, TX, ²Surgery, UT Medical School, Houston, TX
*Purpose: Recent UNOS policy proposals have changed kidney allocation from local Designated Service Areas (DSA) to geographic distribution areas of varying widths. Since crossmatch of…
2020 American Transplant Congress
Synergistic Impact of Obesity and Pre-sensitization in Kidney Transplant Recipients on the Long Term Allograft Survival
Y. Park¹, S. Lee¹, E. Ko¹, T. Ban², J. Min³, H. Yoon⁴, C. Yang¹, B. Chung¹
¹Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Eunpeyong St. Mary's Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Bucheon St. Mary's Hospital, Seoul, Korea, Republic of, ⁴Internal Medicine, Incheon St. Mary's Hospital, Seoul, Korea, Republic of
*Purpose: Obesity is emerging as important health problems worldwide. In recent years, with the development of desensitization therapy, successful kidney transplantation has been performed even…
2020 American Transplant Congress
Selective Dual Co-Stimulatory Blockade of CD28/CD80-86 and PD1-PL2 with a Novel Recombinant Bi-Specific Fusion Protein (Hybri-2) Promotes Successful Humoral Desensitization in a Stringent Sensitized Rat Model
A. Torija, E. Crespo, M. Jarque, N. Bolaños, M. Meneghini, A. Favà, J. Torras, J. Grinyo, O. Bestard
Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
*Purpose: Humoral Alloimmune memory is a main barrier for successful kidney transplantation and is orchestrated by a compartmentalized cellular immune response driven by bone-marrow LLPCs…
2020 American Transplant Congress
Clazakizumab (Anti-IL-6) Induces Foxp3+ Tregs in Highly HLA Sensitized Patients Desensitized for HLAi Transplantation (NCT03380962)
S. C. Jordan, S. Ge, N. Ammerman, M. Toyoda, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamson, C. Myers, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, West Hollywood, CA
*Purpose: Interleukin-6 is an important inflammatory cytokine. In addition, it acts as a growth factor for B-cells, plasma cells and Th17 cells, inhibiting FoxP3+ Treg…
2019 American Transplant Congress
The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model
J. Min¹, H. Lee², B. Kim³, K. Park⁴, K. Doh³, T. Kim⁵, H. Yoon⁶, C. Yang⁷, E. Oh², B. Chung⁷
¹Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-si, Korea, Republic of, ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁴Department of Molecular & Cell Biology, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁵Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea, Republic of, ⁷Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…

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