Articles tagged "Sensitization"

2021 American Transplant Congress
Among Patients with Pre-Transplant Donor-Specific Antibodies, the Disappearance of the Donor-Specific Antibodies at 3 Months is Not Associated with Less Rejection
S. Parajuli, A. Djamali, A. Kharel, B. Alzoubi, N. Bath, N. Garg, F. Aziz, D. Mandelbrot
University of Wisconsin, Madison, WI
*Purpose: The number of sensitized kidney transplant recipients (KTRs) are increasing on the waiting list. Some KTRs receive an organ in the presence of pretransplant…
2021 American Transplant Congress
Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study
H. Lee¹, Y. Park¹, T. Ban², S. Song³, S. Song⁴, J. Yang⁵, C. Ahn⁵, C. Yang¹, B. Chung¹
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s hospital, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s hospital, Seoul, Korea, Republic of, ³Organ Transplantation Center and Department of Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of, ⁴Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea, Republic of, ⁵Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: The aim of this study is to investigate whether or not delayed graft function (DGF) and pre-transplant sensitization has a synergistic adverse effect on…
2021 American Transplant Congress
Sensitized Lung Candidates Experience Reduced Access to Donor Organs
K. Lindblad¹, R. Goff², D. Stewart²
¹UNOS, Richmond, VA, ²UNOS, Richmnd, VA
*Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
2021 American Transplant Congress
Highly Sensitized Simultaneous Liver-kidney Transplant Recipients Show a Reduction in Panel Reactive Antibodies and No Kidney Rejection 1-year Post-transplant
M. Moaddab, J. V. Nolte Fong, C. M. Mobley, A. Saharia, M. J. Hobeika, R. McMillan, S. G. Yi, R. J. Knight, A. Gaber, R. Ghobrial
Houston Methodist Hospital, Houston, TX
*Purpose: The liver is unique in that it is considered an immunologically tolerant organ against graft destruction by antibodies. Simultaneous liver-kidney transplantation (SLKT) are often…
2021 American Transplant Congress
Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
M. Manook¹, W. Flores², R. Schmitz¹, Z. Fitch¹, J. Yoon¹, Y. Bae¹, B. I. Shaw¹, M. Harnois³, S. Permar³, A. Kirk¹, D. Magnani², J. Kwun¹, S. Knechtle¹
¹Duke Transplant Center, Duke University Medical Center, Durham, NC, ²Massbiologics, University of Massachusetts Medical School, Boston, MA, ³Human Vaccine Institute, Duke University Medical Center, Durham, NC
*Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
2021 American Transplant Congress
Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model
J. Kwun¹, E. David², Y. Gu³, Z. Ma³, M. Kuchibhatla⁴, G. Arepally⁵, T. J. Huang³, E. T. Chambers²
¹Surgery, Duke University, Durham, NC, ²Pediatrics, Duke University, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Biostatistics and Bioinformatics, Duke University, Durham, NC, ⁵Internal Medicine, Duke University, Durham, NC
*Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
2021 American Transplant Congress
Low Immunogenic Donors Improve Kidney Transplant Survival in Sensitized Recipients
D. Bekbolsynov¹, R. Green², B. Mierzejewska¹, M. Rees¹, S. Stepkowski¹
¹University of Toledo, Toledo, OH, ²Bowling Green State University, Bowling Green, OH
*Purpose: Our previous results showed that low immunogenicity (IM) donors improved kidney allograft survival in non-sensitized recipients. Herein, we examined how the level of peak…
2021 American Transplant Congress
Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR
M. McGowan¹, A. Bickenbach¹, A. R. Shields², R. R. Alloway¹, P. Brailey¹, E. Portwood¹, C. Alquist¹, A. Christianson¹, B. Abu Jawdeh¹, M. Cuffy¹, J. Kremer², S. Bumb¹, A. Govil¹, M. Anand¹, T. Kaur¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²Christ Hospital, Cincinnati, OH
*Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
2021 American Transplant Congress
Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches
M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle
Duke Transplant Center, Duke University Medical Center, Durham, NC
*Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
2021 American Transplant Congress
Impact of Allosensitization on Xenotransplantation
D. Olaso¹, M. Manook¹, J. Yoon¹, Y. Bae¹, A. Barbas¹, A. Adams², S. Knechtle¹, J. Kwun¹
¹Department of Surgery, Duke Transplantation Center, Durham, NC, ²Department of Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…