ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2021 American Transplant Congress

    Among Patients with Pre-Transplant Donor-Specific Antibodies, the Disappearance of the Donor-Specific Antibodies at 3 Months is Not Associated with Less Rejection

    S. Parajuli, A. Djamali, A. Kharel, B. Alzoubi, N. Bath, N. Garg, F. Aziz, D. Mandelbrot

    University of Wisconsin, Madison, WI

    *Purpose: The number of sensitized kidney transplant recipients (KTRs) are increasing on the waiting list. Some KTRs receive an organ in the presence of pretransplant…
  • 2021 American Transplant Congress

    Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study

    H. Lee1, Y. Park1, T. Ban2, S. Song3, S. Song4, J. Yang5, C. Ahn5, C. Yang1, B. Chung1

    1Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s hospital, Seoul, Korea, Republic of, 2Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s hospital, Seoul, Korea, Republic of, 3Organ Transplantation Center and Department of Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of, 4Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea, Republic of, 5Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: The aim of this study is to investigate whether or not delayed graft function (DGF) and pre-transplant sensitization has a synergistic adverse effect on…
  • 2021 American Transplant Congress

    Sensitized Lung Candidates Experience Reduced Access to Donor Organs

    K. Lindblad1, R. Goff2, D. Stewart2

    1UNOS, Richmond, VA, 2UNOS, Richmnd, VA

    *Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
  • 2021 American Transplant Congress

    Highly Sensitized Simultaneous Liver-kidney Transplant Recipients Show a Reduction in Panel Reactive Antibodies and No Kidney Rejection 1-year Post-transplant

    M. Moaddab, J. V. Nolte Fong, C. M. Mobley, A. Saharia, M. J. Hobeika, R. McMillan, S. G. Yi, R. J. Knight, A. Gaber, R. Ghobrial

    Houston Methodist Hospital, Houston, TX

    *Purpose: The liver is unique in that it is considered an immunologically tolerant organ against graft destruction by antibodies. Simultaneous liver-kidney transplantation (SLKT) are often…
  • 2021 American Transplant Congress

    Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

    M. Manook1, W. Flores2, R. Schmitz1, Z. Fitch1, J. Yoon1, Y. Bae1, B. I. Shaw1, M. Harnois3, S. Permar3, A. Kirk1, D. Magnani2, J. Kwun1, S. Knechtle1

    1Duke Transplant Center, Duke University Medical Center, Durham, NC, 2Massbiologics, University of Massachusetts Medical School, Boston, MA, 3Human Vaccine Institute, Duke University Medical Center, Durham, NC

    *Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
  • 2021 American Transplant Congress

    Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model

    J. Kwun1, E. David2, Y. Gu3, Z. Ma3, M. Kuchibhatla4, G. Arepally5, T. J. Huang3, E. T. Chambers2

    1Surgery, Duke University, Durham, NC, 2Pediatrics, Duke University, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Biostatistics and Bioinformatics, Duke University, Durham, NC, 5Internal Medicine, Duke University, Durham, NC

    *Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
  • 2021 American Transplant Congress

    Low Immunogenic Donors Improve Kidney Transplant Survival in Sensitized Recipients

    D. Bekbolsynov1, R. Green2, B. Mierzejewska1, M. Rees1, S. Stepkowski1

    1University of Toledo, Toledo, OH, 2Bowling Green State University, Bowling Green, OH

    *Purpose: Our previous results showed that low immunogenicity (IM) donors improved kidney allograft survival in non-sensitized recipients. Herein, we examined how the level of peak…
  • 2021 American Transplant Congress

    Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR

    M. McGowan1, A. Bickenbach1, A. R. Shields2, R. R. Alloway1, P. Brailey1, E. Portwood1, C. Alquist1, A. Christianson1, B. Abu Jawdeh1, M. Cuffy1, J. Kremer2, S. Bumb1, A. Govil1, M. Anand1, T. Kaur1, E. S. Woodle1

    1U Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
  • 2021 American Transplant Congress

    Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches

    M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
  • 2021 American Transplant Congress

    Impact of Allosensitization on Xenotransplantation

    D. Olaso1, M. Manook1, J. Yoon1, Y. Bae1, A. Barbas1, A. Adams2, S. Knechtle1, J. Kwun1

    1Department of Surgery, Duke Transplantation Center, Durham, NC, 2Department of Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
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