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American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2021 American Transplant Congress

    Outcomes of Kidney Transplantation in HIV Positive Highly Sensitized Recipients

    S. Karhadkar, J. Panichella, H. Resweber, K. Nguyen, A. Di Carlo, S. Karhadkar

    Temple University School of Medicine, Philadelphia, PA

    *Purpose: Since the introduction of highly active antiretroviral therapy, HIV+ individuals are living longer, which has led to higher rates of end stage renal disease…
  • 2021 American Transplant Congress

    Factors Affecting Sensitization Following Kidney Allograft Failure

    N. Garg, L. Hidalgo, S. Parajuli, F. Aziz, M. Mohamed, A. Djamali, D. Mandelbrot

    UW Madison, Madison, WI

    *Purpose: Kidney transplant (KT) recipients with failed allografts constitute nearly 12% of the current waitlist in the US. Sensitization as a result of graft failure…
  • 2021 American Transplant Congress

    The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara

    S. Ge1, M. Chu1, A. De Guzman1, E. Ortiz1, A. Vo2, N. Ammerman2, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…
  • 2021 American Transplant Congress

    Very Long-Term Patient and Kidney Allograft Outcomes in Kidney Transplant Recipients More Than 20 Years After Transplantation:

    T. Schachtner, A. Reimann, T. Müller

    University Hospital Zurich, Zürich, Switzerland

    *Purpose: Despite rapid medical advancements in the field of transplantation over the last decades, long-term kidney allograft survival only slowly improves. Especially little is known…
  • 2021 American Transplant Congress

    Among Patients with Pre-Transplant Donor-Specific Antibodies, the Disappearance of the Donor-Specific Antibodies at 3 Months is Not Associated with Less Rejection

    S. Parajuli, A. Djamali, A. Kharel, B. Alzoubi, N. Bath, N. Garg, F. Aziz, D. Mandelbrot

    University of Wisconsin, Madison, WI

    *Purpose: The number of sensitized kidney transplant recipients (KTRs) are increasing on the waiting list. Some KTRs receive an organ in the presence of pretransplant…
  • 2021 American Transplant Congress

    Combined Impact of Pre-sensitization and Delayed Graft Function on Allograft Rejection in Deceased Donor Kidney Transplantation: A Nationwide Cohort Study

    H. Lee1, Y. Park1, T. Ban2, S. Song3, S. Song4, J. Yang5, C. Ahn5, C. Yang1, B. Chung1

    1Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s hospital, Seoul, Korea, Republic of, 2Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s hospital, Seoul, Korea, Republic of, 3Organ Transplantation Center and Department of Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of, 4Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea, Republic of, 5Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: The aim of this study is to investigate whether or not delayed graft function (DGF) and pre-transplant sensitization has a synergistic adverse effect on…
  • 2021 American Transplant Congress

    Sensitized Lung Candidates Experience Reduced Access to Donor Organs

    K. Lindblad1, R. Goff2, D. Stewart2

    1UNOS, Richmond, VA, 2UNOS, Richmnd, VA

    *Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
  • 2021 American Transplant Congress

    Highly Sensitized Simultaneous Liver-kidney Transplant Recipients Show a Reduction in Panel Reactive Antibodies and No Kidney Rejection 1-year Post-transplant

    M. Moaddab, J. V. Nolte Fong, C. M. Mobley, A. Saharia, M. J. Hobeika, R. McMillan, S. G. Yi, R. J. Knight, A. Gaber, R. Ghobrial

    Houston Methodist Hospital, Houston, TX

    *Purpose: The liver is unique in that it is considered an immunologically tolerant organ against graft destruction by antibodies. Simultaneous liver-kidney transplantation (SLKT) are often…
  • 2021 American Transplant Congress

    Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

    M. Manook1, W. Flores2, R. Schmitz1, Z. Fitch1, J. Yoon1, Y. Bae1, B. I. Shaw1, M. Harnois3, S. Permar3, A. Kirk1, D. Magnani2, J. Kwun1, S. Knechtle1

    1Duke Transplant Center, Duke University Medical Center, Durham, NC, 2Massbiologics, University of Massachusetts Medical School, Boston, MA, 3Human Vaccine Institute, Duke University Medical Center, Durham, NC

    *Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
  • 2021 American Transplant Congress

    Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model

    J. Kwun1, E. David2, Y. Gu3, Z. Ma3, M. Kuchibhatla4, G. Arepally5, T. J. Huang3, E. T. Chambers2

    1Surgery, Duke University, Durham, NC, 2Pediatrics, Duke University, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Biostatistics and Bioinformatics, Duke University, Durham, NC, 5Internal Medicine, Duke University, Durham, NC

    *Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
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