ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2022 American Transplant Congress

    Pre-Transplant Desensitization Utilizing Intravenous Immune-Globulin and Tocilizumab: A Single Center Experience

    I. Moinuddin, M. Miles, S. Sterling, A. Brown, P. Kimball, G. Gupta

    Virginia Commonwealth University Health System, Richmond, VA

    *Purpose: Highly sensitized end stage kidney disease patients face a huge barrier to transplant due to lack of effective pre-transplant desensitization therapies. Various strategies have…
  • 2021 American Transplant Congress

    Sensitized Lung Candidates Experience Reduced Access to Donor Organs

    K. Lindblad1, R. Goff2, D. Stewart2

    1UNOS, Richmond, VA, 2UNOS, Richmnd, VA

    *Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
  • 2021 American Transplant Congress

    Highly Sensitized Simultaneous Liver-kidney Transplant Recipients Show a Reduction in Panel Reactive Antibodies and No Kidney Rejection 1-year Post-transplant

    M. Moaddab, J. V. Nolte Fong, C. M. Mobley, A. Saharia, M. J. Hobeika, R. McMillan, S. G. Yi, R. J. Knight, A. Gaber, R. Ghobrial

    Houston Methodist Hospital, Houston, TX

    *Purpose: The liver is unique in that it is considered an immunologically tolerant organ against graft destruction by antibodies. Simultaneous liver-kidney transplantation (SLKT) are often…
  • 2021 American Transplant Congress

    Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

    M. Manook1, W. Flores2, R. Schmitz1, Z. Fitch1, J. Yoon1, Y. Bae1, B. I. Shaw1, M. Harnois3, S. Permar3, A. Kirk1, D. Magnani2, J. Kwun1, S. Knechtle1

    1Duke Transplant Center, Duke University Medical Center, Durham, NC, 2Massbiologics, University of Massachusetts Medical School, Boston, MA, 3Human Vaccine Institute, Duke University Medical Center, Durham, NC

    *Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
  • 2021 American Transplant Congress

    Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model

    J. Kwun1, E. David2, Y. Gu3, Z. Ma3, M. Kuchibhatla4, G. Arepally5, T. J. Huang3, E. T. Chambers2

    1Surgery, Duke University, Durham, NC, 2Pediatrics, Duke University, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Biostatistics and Bioinformatics, Duke University, Durham, NC, 5Internal Medicine, Duke University, Durham, NC

    *Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
  • 2021 American Transplant Congress

    Low Immunogenic Donors Improve Kidney Transplant Survival in Sensitized Recipients

    D. Bekbolsynov1, R. Green2, B. Mierzejewska1, M. Rees1, S. Stepkowski1

    1University of Toledo, Toledo, OH, 2Bowling Green State University, Bowling Green, OH

    *Purpose: Our previous results showed that low immunogenicity (IM) donors improved kidney allograft survival in non-sensitized recipients. Herein, we examined how the level of peak…
  • 2021 American Transplant Congress

    Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR

    M. McGowan1, A. Bickenbach1, A. R. Shields2, R. R. Alloway1, P. Brailey1, E. Portwood1, C. Alquist1, A. Christianson1, B. Abu Jawdeh1, M. Cuffy1, J. Kremer2, S. Bumb1, A. Govil1, M. Anand1, T. Kaur1, E. S. Woodle1

    1U Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
  • 2021 American Transplant Congress

    Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches

    M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
  • 2021 American Transplant Congress

    Impact of Allosensitization on Xenotransplantation

    D. Olaso1, M. Manook1, J. Yoon1, Y. Bae1, A. Barbas1, A. Adams2, S. Knechtle1, J. Kwun1

    1Department of Surgery, Duke Transplantation Center, Durham, NC, 2Department of Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
  • 2021 American Transplant Congress

    Successful Prophylaxis of Antibody-Mediated Rejection by Downregulation of C5 Expression via RNA Interference in a Rat Kidney Transplant Model

    H. Ishigooka1, S. Motoi2, T. Yamakawa1, C. Matsui2, Y. Suzuki3, R. Ishii1, K. Saiga1, D. Tokita1, T. Imai2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2KAN Research Institute, Inc., Kobe, Japan, 3Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan

    *Purpose: Antibody-mediated rejection (AMR) is a major contributor towards poor prognosis in kidney transplantation. Circulating donor-specific antibodies (DSAs) cause AMR with complement activation. This study…
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