ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2022 American Transplant Congress

    Belatacept-Based Maintenance Immunosuppression Promoted Long-Term Antibody-Mediated Rejection Free Graft Survival After Desensitization in Sensitized Multiparous Female Recipients

    M. Manook, I. Anwar, R. Schmitz, Z. Fitch, J. Yoon, A. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Durham, NC

    *Purpose: Amongst sensitized patients awaiting a transplant, females are disproportionately represented. To date, nonhuman primate (NHP) models of transplantation have relied on male animals, sensitized…
  • 2021 American Transplant Congress

    Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR

    M. McGowan1, A. Bickenbach1, A. R. Shields2, R. R. Alloway1, P. Brailey1, E. Portwood1, C. Alquist1, A. Christianson1, B. Abu Jawdeh1, M. Cuffy1, J. Kremer2, S. Bumb1, A. Govil1, M. Anand1, T. Kaur1, E. S. Woodle1

    1U Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
  • 2021 American Transplant Congress

    Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches

    M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
  • 2021 American Transplant Congress

    Impact of Allosensitization on Xenotransplantation

    D. Olaso1, M. Manook1, J. Yoon1, Y. Bae1, A. Barbas1, A. Adams2, S. Knechtle1, J. Kwun1

    1Department of Surgery, Duke Transplantation Center, Durham, NC, 2Department of Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Sensitization to human leukocyte antigens (HLA) due to prior exposure to foreign antigens through events such as blood transfusions, previous kidney transplant, or pregnancy…
  • 2021 American Transplant Congress

    Successful Prophylaxis of Antibody-Mediated Rejection by Downregulation of C5 Expression via RNA Interference in a Rat Kidney Transplant Model

    H. Ishigooka1, S. Motoi2, T. Yamakawa1, C. Matsui2, Y. Suzuki3, R. Ishii1, K. Saiga1, D. Tokita1, T. Imai2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2KAN Research Institute, Inc., Kobe, Japan, 3Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan

    *Purpose: Antibody-mediated rejection (AMR) is a major contributor towards poor prognosis in kidney transplantation. Circulating donor-specific antibodies (DSAs) cause AMR with complement activation. This study…
  • 2021 American Transplant Congress

    Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women

    J. T. Killian1, J. A. Houp1, A. Nellore2, R. G. King3, P. M. Porrett1, F. E. Lund3

    1Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 2Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, 3Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL

    *Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…
  • 2021 American Transplant Congress

    Anti-HLA-DP Antibodies Positive – A Retrospective Review of Outcomes in Renal Transplantation- Single Centre Experience

    O. Piscoran1, J. Worthington2, R. Dhillon1, T. Augustine1, M. Picton1, M. Morton1, S. Bhutani1

    1Urology, Renal and Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 2Transplantation Laboratory, Manchester University NHS Foundation Trust, Manchester, United Kingdom

    *Purpose: Data on the role of HLA-DP antibodies on graft outcome is not precise. Studies suggested that the presence of donor-directed HLA-DP antibodies correlate with…
  • 2021 American Transplant Congress

    Anti-pig IgE and IgA Antibodies in Sera of (i) Naïve Primates and (ii) Non-human Primates Sensitized to Pig Xenografts

    H. Hara, Q. Li, H. Iwase, T. Yamamoto, D. Ayares, D. K. Cooper

    University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Anti-pig IgM and IgG antibodies in primates play an important role in xenograft rejection. The possible roles of anti-pig IgE and IgA have not…
  • 2021 American Transplant Congress

    The Incremental Cost of Transplanting Patients with 100% cPRA Under the Kidney Allocation System: A Single Center Analysis

    R. Gumber, E. Kraus, K. Jackson, N. Alachkar

    Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Our group has described excellent three year patient and graft survival in patients with 100% cPRA undergoing kidney transplantation under the Kidney Allocation System…
  • 2021 American Transplant Congress

    Outcomes in Highly Sensitized Kidney Transplant Recipients Receiving DCD Organs

    A. Diamond1, L. Rodrigues2, A. Di Carlo3, S. Karhadkar3

    1Pharmacy, Temple University Hospital, Philadelphia, PA, 2Temple University, Philadelphia, PA, 3Surgery, Temple University Hospital, Philadelphia, PA

    *Purpose: Highly sensitized (HS) patients experience longer wait times for kidney transplantation despite prioritization by the Kidney Allocation System. Kidney transplants performed from donors defined…
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