Articles tagged "Sensitization"

2022 American Transplant Congress
Beyond CPRA: Identifying Sensitized Kidney Candidates with Markedly Low Access to Transplant
K. Bradbrook¹, A. Maldonado², K. Sjöholm², C. Kjellman², J. Lee³, D. Stewart¹
¹UNOS, Richmond, VA, ²Hansa Biopharma AB, Lund, Sweden, ³Immucor, Norcross, GA
*Purpose: The Kidney Allocation System (KAS) improved the rates of transplantation in highly sensitized (HS) patients. However, a subset of HS patients remain at a…
2021 American Transplant Congress
Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women
J. T. Killian¹, J. A. Houp¹, A. Nellore², R. G. King³, P. M. Porrett¹, F. E. Lund³
¹Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, ³Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL
*Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…
2021 American Transplant Congress
Anti-HLA-DP Antibodies Positive – A Retrospective Review of Outcomes in Renal Transplantation- Single Centre Experience
O. Piscoran¹, J. Worthington², R. Dhillon¹, T. Augustine¹, M. Picton¹, M. Morton¹, S. Bhutani¹
¹Urology, Renal and Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ²Transplantation Laboratory, Manchester University NHS Foundation Trust, Manchester, United Kingdom
*Purpose: Data on the role of HLA-DP antibodies on graft outcome is not precise. Studies suggested that the presence of donor-directed HLA-DP antibodies correlate with…
2021 American Transplant Congress
Anti-pig IgE and IgA Antibodies in Sera of (i) Naïve Primates and (ii) Non-human Primates Sensitized to Pig Xenografts
H. Hara, Q. Li, H. Iwase, T. Yamamoto, D. Ayares, D. K. Cooper
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Anti-pig IgM and IgG antibodies in primates play an important role in xenograft rejection. The possible roles of anti-pig IgE and IgA have not…
2021 American Transplant Congress
The Incremental Cost of Transplanting Patients with 100% cPRA Under the Kidney Allocation System: A Single Center Analysis
R. Gumber, E. Kraus, K. Jackson, N. Alachkar
Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Our group has described excellent three year patient and graft survival in patients with 100% cPRA undergoing kidney transplantation under the Kidney Allocation System…
2021 American Transplant Congress
Outcomes in Highly Sensitized Kidney Transplant Recipients Receiving DCD Organs
A. Diamond¹, L. Rodrigues², A. Di Carlo³, S. Karhadkar³
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Temple University, Philadelphia, PA, ³Surgery, Temple University Hospital, Philadelphia, PA
*Purpose: Highly sensitized (HS) patients experience longer wait times for kidney transplantation despite prioritization by the Kidney Allocation System. Kidney transplants performed from donors defined…
2021 American Transplant Congress
Outcomes of Kidney Transplantation in HIV Positive Highly Sensitized Recipients
S. Karhadkar, J. Panichella, H. Resweber, K. Nguyen, A. Di Carlo, S. Karhadkar
Temple University School of Medicine, Philadelphia, PA
*Purpose: Since the introduction of highly active antiretroviral therapy, HIV+ individuals are living longer, which has led to higher rates of end stage renal disease…
2021 American Transplant Congress
Factors Affecting Sensitization Following Kidney Allograft Failure
N. Garg, L. Hidalgo, S. Parajuli, F. Aziz, M. Mohamed, A. Djamali, D. Mandelbrot
UW Madison, Madison, WI
*Purpose: Kidney transplant (KT) recipients with failed allografts constitute nearly 12% of the current waitlist in the US. Sensitization as a result of graft failure…
2021 American Transplant Congress
The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara
S. Ge¹, M. Chu¹, A. De Guzman¹, E. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…
2021 American Transplant Congress
Very Long-Term Patient and Kidney Allograft Outcomes in Kidney Transplant Recipients More Than 20 Years After Transplantation:
T. Schachtner, A. Reimann, T. Müller
University Hospital Zurich, Zürich, Switzerland
*Purpose: Despite rapid medical advancements in the field of transplantation over the last decades, long-term kidney allograft survival only slowly improves. Especially little is known…