Articles tagged "Sensitization"

2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
S. Stepkowski, B. Mierzejewska, C. Baum, D. Bekbolsynov, R. Brunner, J. Kopke, S. Rees, M. Rees.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…
2017 American Transplant Congress
Exploring Differential Antibody Response to Bortezomib in Heart Transplantation.
K. Ghafourian, R. Hod-Dvorai, S. McCabe, N. Cool, M. Fine, M. Ackerman, J. Rich, J. Wilcox, E. Vorovich, A. Anderson, A. Tambur.
Northwestern University, Chicago, IL
Twelve heart transplant candidates (2013-2016) received Bortezomib (BTZ) for desensitization. Differential antibody (Ab) response was observed. BTZ cycles consisted of 4 injections of 1.3 mg/m2;…
2017 American Transplant Congress
Even with National Sharing, the Prospects of a 100% Sensitized Patient Receiving a Transplant Vary Dramatically Depending on the Precise CPRA Value.
D. Stewart,¹ A. Kucheryavaya,¹ D. Tyan,² H. Gebel,³ R. Bray,³ N. Turgeon.³
¹UNOS, Richmond, VA; ²Stanford Univ, Palo Alto, CA; ³Emory Univ Hosp, Atlanta, GA
Background: In the Kidney Allocation System (KAS), CPRA of 99% & 100% candidates receive regional and national priority. This broader sharing, along with adoption of…
2017 American Transplant Congress
Post-Transplant Sensitization: Does it Make a Difference in the Development of First-Year Intimal Thickening?
J. Patel, M. Kittleson, L. Czer, T. Aintablian, E. Stimpson, B. Azarbal, D. Geft, D. Chang, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: The development of donor specific antibody (DSA) after heart transplantation has been reported to be associated with the development of cardiac allograft vasculopathy (CAV).…
2017 American Transplant Congress
Waitlist Desensitization and the Rate of Deceased Donor Kidney Transplantation After Implementation of the Kidney Allocation System.
E. Huang, S. Jordan, R. Najjar, J. Choi, A. Peng, A. Vo.
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
Background:At Cedars Sinai Medical Center (CSMC), candidates with calculated panel reactive antibodies (cPRA) ≥30% (based on unacceptable antigens with MFI≥15,000) are desensitized while awaiting transplant.…
2017 American Transplant Congress
CTLA4-Ig in Combination with FTY720 Reduces the Frequency of Memory Alloreactive T Cells and Promotes Heart Allograft Survival in Sensitized Recipients.
S. Khiew,¹ J. Yang,¹ J. Young,¹ J. Chen,¹ Q. Wang,¹ D. Ying,¹ V. Vu,¹ M. Miller,² R. Sciammas,³ M.-L. Alegre,² A. Chong.¹
¹Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL; ²Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL; ³Center for Comparative Medicine, University of California, Davis, CA
Despite recent evidence of improved graft outcomes and safety, high incidence of early acute cellular rejection with belatacept has limited its use in clinical transplantation.…
2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
R. Crepeau, D. Liu, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…
2017 American Transplant Congress
Induction of Sensitization and Resistance to Transplant Tolerance by Allogeneic Pregnancy.
A. Suah,¹ J. Young,¹ S. Hsu-Wei Khiew,¹ Q. Wang,¹ D. Yin,¹ M.-L. Alegre,² A. Chong.¹
¹Department of Surgery, University of Chicago, Chicago, IL; ²Department of Medicine, University of Chicago, Chicago, IL
Background: Clinical data suggest allogeneic pregnancy is a sensitizing event; yet, recent data from mouse models suggest it induces fetal-specific regulatory T cell (Treg) expansion…
2017 American Transplant Congress
A Combination of Anti-CD40L-Ab, Rapamycin, and Donor Apoptotic Cells Prolongs Allogeneic Pancreatic Islet Survival in Sensitized Mice by Regulating Memory Responses.
A. Dangi,¹ H.-K. Kang,¹ X. Zhang,^2,3 X. Luo.^1,2,3
¹Nephrology and Hypertension, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL; ³Surgery, Northwestern University, Chicago, IL
Accelerated rejection of allografts has been a clinical challenge in solid organ transplantation particularly in sensitized recipients with donor-specific antibodies (DSA) and memory cell repertoires.…
2017 American Transplant Congress
Blood Transfusion Before Organ Transplant: Patient Sensitization and Outcomes.
I. Cich, K. Rudser, R. Brown, H. Ibrahim, R. Thorson, J. Patil, G. Loor, M. Hertz, C. Cohn.
Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
BackgroundBlood transfusions (Btf) can cause alloimmunization to HLA antigens. Antibodies to HLA (HLAb) can increase patients' calculated panel reactive assay (cPRA) and make it more…