2017 American Transplant Congress
Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.
Duke University Medical Center, Durham, NC; Cedars-Sinai Medical Center, Los Angeles, CA
Purpose:Sensitized recipients have poor access to kidney transplantation (KT) and worse outcomes when transplanted. We have shown that bortezomib inhibits plasma cells (PCs), but does…2017 American Transplant Congress
Long-Term Persistence of Anti-HLA Antibodies in Renal Trasplant Recipients: Risk Factors and Impact on Clinical Course.
Objectives:1) To evaluate the incidence of development of anti-HLA antibodies on the long run in our renal transplant population and the main risk factors for…2017 American Transplant Congress
De Novo Donor-Specific Antibodies After Allograft Nephrectomy.
Introduction: although the development of donor-specific antibodies (DSAs) is a known event after allograft nephrectomy (Nx), there are few studies describing the tempo, class and…2017 American Transplant Congress
Prevention of Donor Specific Antibody Production After Skin Allografting by Mobilization of Endogenous Stem Cells Using a Combination of AMD3100 and Low-Dose FK506 in Rats.
Background: We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in small and large animals…2017 American Transplant Congress
Significant Allosensitisation Despite Early, within 24 Hour, Graft Nephrectomy.
Introduction: Although it is well known that allograft nephrectomy (Nx) is followed by the development of donor-specific antibodies (DSAs) even after a short transplant period,…2017 American Transplant Congress
HLA Alloimmunization According to the Different Immunization Events and Consequences on Access to Kidney Transplantation.
Patients awaiting solid organ transplantation may develop anti-HLA antibodies after sensitization events such as transfusions, pregnancies or previous transplantations. The aim of our work was…2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…2017 American Transplant Congress
Exploring Differential Antibody Response to Bortezomib in Heart Transplantation.
Northwestern University, Chicago, IL
Twelve heart transplant candidates (2013-2016) received Bortezomib (BTZ) for desensitization. Differential antibody (Ab) response was observed. BTZ cycles consisted of 4 injections of 1.3 mg/m2;…2017 American Transplant Congress
Even with National Sharing, the Prospects of a 100% Sensitized Patient Receiving a Transplant Vary Dramatically Depending on the Precise CPRA Value.
1UNOS, Richmond, VA; 2Stanford Univ, Palo Alto, CA; 3Emory Univ Hosp, Atlanta, GA
Background: In the Kidney Allocation System (KAS), CPRA of 99% & 100% candidates receive regional and national priority. This broader sharing, along with adoption of…2017 American Transplant Congress
Post-Transplant Sensitization: Does it Make a Difference in the Development of First-Year Intimal Thickening?
Cedars-Sinai Heart Institute, Los Angeles
Background: The development of donor specific antibody (DSA) after heart transplantation has been reported to be associated with the development of cardiac allograft vasculopathy (CAV).…
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