ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sensitization"

  • 2018 American Transplant Congress

    Donor Specific Antibodies Increase the Risk of Preeclampsia in Pregnant Kidney Transplant Recipients

    M. Lubetzky, T. Muthukumar, J. Lee, J. Lee, C. Hartono, L. Mahla, D. Serur, D. Dadhania.

    Weill Cornell-New York Presbyterian, NY, NY.

    Kidney transplant recipients are at an increased risk for pregnancy-associated complications including preeclampsia (PEC). Endothelial injury in the placenta is a hallmark of PEC. The…
  • 2018 American Transplant Congress

    Temporal Changes in the Characteristics and Sensitization of Kidney Paired Donation Registrants

    C. Holscher,1 K. Jackson,1 A. Thomas,1 C. Haugen,1 S. DiBrito,1 M. Ronin,2 A. Waterman,3,4 A. Massie,1,5 J. Garonzik Wang,1 D. Segev.1,5

    1Johns Hopkins School of Medicine, Baltimore; 2National Kidney Registry, New York; 3David Geffen School of Medicine at UCLA, Los Angeles; 4Terasaki Research Institute, Los Angeles; 5Johns Hopkins School of Public Health, Baltimore.

    In order to utilize a willing but incompatible living donor, candidates must either proceed with incompatible transplantation or find a more compatible match using kidney…
  • 2018 American Transplant Congress

    mRNA Transcript Profiling of 3 Genes in Renal Allograft Biopsies (Bx) Improves Accuracy of Antibody-Mediated Rejection (ABMR) Diagnosis in Transplant Recipients Desensitized with IVIG+Rituximab+Immunoglobulin G-Degrading Enzyme of Streptococcus Pyogenes (IdeS)

    H. Zhang,1 C. Nast,2 J. Doldron,2 M. Cheung,2 A. Vo,3 S. Jordan,3 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; 2Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; 3Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: Multiple molecular signatures specific to ABMR based on gene expression in renal allograft Bx of transplant recipients were reported. Here we assessed mRNA transcript…
  • 2018 American Transplant Congress

    The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…
  • 2018 American Transplant Congress

    Mid-Term Outcome of Donor Specific Antibody Positive Deceased Donor Kidney Transplantation with Peri-Transplant Desensitization

    K. Osickova,1 P. Hruba,2 J. Slatinska,1 A. Slavcev,2 J. Fronek,2 E. Honsova,2 O. Viklicky.1

    1Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

    Donor specific HLA-antibodies (DSA) remain a large barrier to successful kidney transplantation and there is a limited knowledge about desensitization strategies in deceased donor programs.Anti…
  • 2018 American Transplant Congress

    Desensitization to Facilitate Matching in a Large, National Kidney Paired Exchange Clearinghouse

    C. Holscher,1 A. Thomas,1 K. Jackson,1 C. Haugen,1 M. Ronin,2 A. Waterman,3,4 A. Massie,1,5 J. Garonzik Wang,1 D. Segev.1,5

    1Johns Hopkins School of Medicine, Baltimore; 2National Kidney Registry, New York; 3David Geffen School of Medicine at UCLA, Los Angeles; 4Terasaki Research Institute, Los Angeles; 5Johns Hopkins School of Public Health, Baltimore.

    In kidney paired exchange (KPE) programs, the use of incompatible transplantation has been necessary to prevent long waiting times for sensitized candidates and to facilitate…
  • 2018 American Transplant Congress

    Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome

    M. Olymbios, J. Patel, R. Levine, S. Dimbil, M. Kittleson, M. Rafiei, X. Zhang, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…
  • 2018 American Transplant Congress

    Assessing Response to Desensitization: What Makes Sense?

    E. Kransdorf, J. Patel, M. Kittleson, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…
  • 2017 American Transplant Congress

    Significant Allosensitisation Despite Early, within 24 Hour, Graft Nephrectomy.

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom

    Introduction: Although it is well known that allograft nephrectomy (Nx) is followed by the development of donor-specific antibodies (DSAs) even after a short transplant period,…
  • 2017 American Transplant Congress

    HLA Alloimmunization According to the Different Immunization Events and Consequences on Access to Kidney Transplantation.

    V. Pernin,1 A. Cros,1 I. Szwarc,1 C. Rene,2 J.-F. Eliaou,2 V. Garrigue,1 G. Mourad,1 M. Le Quintrec-Donnette.1

    1Department Nephrology and Transplantation, CHU Lapeyronie, Montpellier, France; 2Department of Immunology, CHU St ELoi, Montpellier, France

    Patients awaiting solid organ transplantation may develop anti-HLA antibodies after sensitization events such as transfusions, pregnancies or previous transplantations. The aim of our work was…
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