2018 American Transplant Congress
Mid-Term Outcome of Donor Specific Antibody Positive Deceased Donor Kidney Transplantation with Peri-Transplant Desensitization
Donor specific HLA-antibodies (DSA) remain a large barrier to successful kidney transplantation and there is a limited knowledge about desensitization strategies in deceased donor programs.Anti…2018 American Transplant Congress
Desensitization to Facilitate Matching in a Large, National Kidney Paired Exchange Clearinghouse
In kidney paired exchange (KPE) programs, the use of incompatible transplantation has been necessary to prevent long waiting times for sensitized candidates and to facilitate…2018 American Transplant Congress
Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome
Cedars Sinai Medical Center, Los Angeles.
Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…2018 American Transplant Congress
Assessing Response to Desensitization: What Makes Sense?
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…2018 American Transplant Congress
What Threshold MFI is the Luminex 1:8 Dilution the Poor Man's C1q for Patients Awaiting Heart Transplant?
Cedars Sinai Medical Center, Los Angeles.
Purpose: Heart transplant candidates are evaluated for anti-HLA antibodies by Luminex single-antigen bead testing to avoid donors that may harbor antigens that these antibodies are…2018 American Transplant Congress
Pre-Transplant Memory Patients Even without Detected Antibody Are at Rejection Risk in the First-Year after Heart Transplantation
Cedars Sinai Medical Center, Los Angeles.
Purpose: Patients (pts) with prior transplants, blood transfusions, and pregnancies awaiting heart transplantation (HTx) have potential to develop circulating anti-HLA antibodies (HLA Abs). Pts at…2018 American Transplant Congress
MCS and Desensitization
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitization prior to heart transplantation (HTx) has been associated with increased mortality and rates of rejection as well as an increased incidence of cardiac…2018 American Transplant Congress
Evanescent Antibodies: A Report on the Natural History of Anti-Blood Group A2 Antibodies and Their Rapid Resolution in Patients Awaiting A2 to B Transplantation
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Despite the benefits of A2 to B transplants, centers have been reluctant to adopt such a program due to unanswered questions including whether elevation…2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…2017 American Transplant Congress
Induction of Sensitization and Resistance to Transplant Tolerance by Allogeneic Pregnancy.
Background: Clinical data suggest allogeneic pregnancy is a sensitizing event; yet, recent data from mouse models suggest it induces fetal-specific regulatory T cell (Treg) expansion…
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